Results 291 to 300 of about 45,916 (341)

Synthesis, in‐vitro and in‐silico study of novel thiazoles as potent antibacterial agents and MurB inhibitors

Archiv der Pharmazie, 2020
Efficient procedures are herein reported for the synthesis of novel hybrid thiazoles via a one‐pot three‐component protocol. The protocol involves the reaction of novel aldehyde, thiosemicarbazide and halogen‐containing reagents in solvent‐ and catalyst ...
S. Sanad, Ahmed A. M. Ahmed, Ahmed E. M. Mekky   +2 more
semanticscholar   +1 more source

An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators.

Future Medicinal Chemistry, 2020
Aim: With the increasing emergence of drug-resistant bacteria, the need for new antimicrobial agents has become extremely urgent. This work was to develop sulfonyl thiazoles as potential antibacterial agents.
Yuan-Yuan Hu, Juan Wang, Tiejun Li, Rammohan R. Yadav Bheemanaboina, M. Ansari, Yu Cheng, Cheng‐He Zhou   +6 more
semanticscholar   +1 more source

Thiazoles

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
D. Kikelj, U. Urleb
openaire   +1 more source

Antiprotozoal thiazoles. 2-(5-Nitro-2-thienyl)thiazoles

Journal of Medicinal Chemistry, 1975
A series of 2-(5-nitro-2-thienyl)thiazoles and their vinylogs having substituted methylamine side chains has been prepared by halogen displacement on the corresponding 4-chloromethylthiazole. Of these, 4-morpholinomethyl-2-(5-nitro-2-thienyl)thiazole showed moderate activity against Trypanosoma cruzi and Trypanosoma rhodesiense in mice.
J P, Verge, P, Roffey
openaire   +2 more sources

Synthetic and Medicinal Perspective of Fused-Thiazoles as Anticancer Agents.

Anti-Cancer Agents in Medicinal Chemistry, 2020
Fused triazole had explored their apartment as one of the important class of heterocycles, extensively used by chemists due to their diverse pharmacological activities in both synthetic organic chemistry and systemic biological field.
S. Pawar, Kapil Kumar, M. Gupta, R. Rawal   +3 more
semanticscholar   +1 more source

Thiazole-Mediated Synthetic Methodology

Chemical Reviews, 2004
Review of synthetic schemes which have been developed in about 20 years of research by the use of thiazole-based methodology may serve to illustrate the potential of this approach in synthetic programs toward the construction of complex systems or special molecular fragments.
DONDONI, Alessandro, MARRA, Alberto
openaire   +2 more sources

A comprehensive review on the therapeutic versatility of imidazo[2,1-b]- thiazoles.

Current Medicinal Chemistry, 2020
BACKGROUND Imidazo[2,1-b]thiazole, a well known fused five membered hetrocycle, is one of the most promising and versatile moiety in the area of medicinal chemistry.
M. Shareef, Irfan Khan, B. N. Babu, A. Kamal   +3 more
semanticscholar   +1 more source

Cu(I)-Catalyzed Three-Component Cyclization for the Construction of Functionalized Thiazoles.

Journal of Organic Chemistry, 2020
A novel and straightforward strategy for the synthesis of functionalized thiazoles from thioamides, ynals, and alcohols via copper(I)-catalyzed three-component reaction has been described.
Yajun Wang, Xiang Liu, B. Zhu, P. Guo, Yongyan Pei, Qiuxing He, H. Cao   +6 more
semanticscholar   +1 more source

Palladium-Catalyzed Template Directed C-5 Selective Olefination of Thiazoles.

Journal of Organic Chemistry, 2019
An efficient method has been developed to afford highly C-5 selective olefination of thiazole derivatives utilizing a bifunctional template in an intermolecular fashion.
Tapas Kumar Achar, J. Biswas, Sandip Porey, Tapas Pal, Kankanala Ramakrishna, S. Maiti, D. Maiti   +6 more
semanticscholar   +1 more source

I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles.

Organic and biomolecular chemistry, 2019
The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources.
Li Liu, Chen Tan, R. Fan, Zihan Wang, H. Du, Kun Xu, Jiajing Tan   +6 more
semanticscholar   +1 more source