Results 11 to 20 of about 38,393 (221)

Thiazolidinediones [PDF]

Treatments in Endocrinology, 2006
Our knowledge and understanding of the role played by peroxisome proliferator-activated gamma receptors in physiology and pathophysiology has expanded dramatically over the past 5 years. Originally described as having important functions in adipogenesis and glucose homeostasis, their pharmacologic agonists, the thiazolidinediones, were introduced as ...
Kathryn, Reynolds, Ronald B, Goldberg
  +7 more sources

Daily Intraperitoneal Administration of Rosiglitazone Does Not Improve Lung Function or Alveolarization in Preterm Rabbits Exposed to Hyperoxia

Pharmaceutics, 2022
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia.
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen   +21 more
doaj   +1 more source

Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

PLoS ONE, 2014
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the ...
Dongfeng Zhao, Zhenqi Shi, Amy H Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng   +6 more
doaj   +1 more source

The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes

Biomolecules, 2022
The number of patients with type 2 diabetes mellitus (T2DM), which is mainly characterized by insulin resistance and insulin secretion deficiency, has been soaring in recent years.
Xiaohui Ji, Wenqian Zhang, Liqin Yin, Zunhan Shi, Jinwen Luan, Linshan Chen, Longhua Liu   +6 more
doaj   +1 more source

Association between colorectal cancer and thiazolidinediones administration in a case-control study

BioMedicine, 2019
Objectives: This study was designed to assess whether there was an association between colorectal cancer and thiazolidinediones use. Methods: A population-based case-control study was performed using the database of the Taiwan National Health ...
Liao Kuan-Fu, Lin Cheng-Li, Lai Shih-Wei
doaj   +1 more source

Short-term therapy with rosiglitatzone, a PPAR-¿ agonist improves metabolic profile and vascular function in non-obese lean wistar rats [PDF]

, 2012
A number of preclinical and clinical studies have reported blood-pressure-lowering benefits of thiazolidinediones in diabetic subjects and animal models of diabetes.
Abubakari, Abdul-Razak, Itua, Imose, Naderali, Ebrahim K., Naderali, Mohammad M.   +3 more
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Self-controlled case series with multiple event types [PDF]

, 2017
Self-controlled case series methods for events that may be classified as one of several types are described. When the event is non-recurrent, the different types correspond to competing risks.
Douglas, Ian J., Farrington, C. Paddy, Ghebremichael-Weldeselassie, Yonas, Smeeth, Liam, Whitaker, Heather J.   +4 more
core   +1 more source

Effects of Thiazolidinedione and New Antidiabetic Agents on Stroke [PDF]

Journal of Stroke, 2019
Patients with hyperglycemia are at a high risk of cardio- and cerebrovascular diseases. Diabetes patients also have poor outcomes after cerebrovascular disease development.
Chang Ho Ahn, Soo Lim
doaj   +1 more source

Effects of vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure: a randomized placebo-controlled trial [PDF]

, 2017
Objectives: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction.
Bolli, Geremia B., Kothny, Wolfgang, Kozlovski, Plamen, Krum, Henry, Lewsey, James D., Lukashevich, Valentina, McMurray, John J.V., Ponikowski, Piotr   +7 more
core   +2 more sources

Adsorption Mechanism of Eco-Friendly Corrosion Inhibitors for Exceptional Corrosion Protection of Carbon Steel: Electrochemical and First-Principles DFT Evaluations

Metals, 2022
In the present work, we represent two thiazolidinediones, namely (Z)-5-(4-methoxybenzylidene) thiazolidine-2,4-dione (MeOTZD) and (Z)-5-(4-methylbenzylidene) thiazolidine-2,4-dione (MeTZD), as corrosion inhibitors for carbon steel (CS) in 1.0 M HCl ...
Abdelkarim Chaouiki, Maryam Chafiq, Young Gun Ko, Aisha H. Al-Moubaraki, Fatima Zahra Thari, Rachid Salghi, Khalid Karrouchi, Khalid Bougrin, Ismat H. Ali, Hassane Lgaz   +9 more
doaj   +1 more source