Results 21 to 30 of about 24,744 (229)
Oral hypoglycaemic drugs and newer agents use in Type 2 diabetes mellitus
South African Family Practice, 2009 We have reviewed the use of oral agents in the management of Type 2 diabetes, together with their pharmacological mechanisms, indications, side effects and contra-indications. The principal oral agents available for use include metformin, sulphonylureas,
P. Joshi, S. Joshi
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Ожирение и метаболизм, 2009 The review article highlights the main effects of therapeutic strategies on proinflammatory and procoagulant abnormalities which accompany metabolic syndrome.
doaj +1 more source
Medical Sciences, 2023 Type 2 diabetes mellitus (T2DM) is the world’s most common metabolic disease. The development of T2DM is mainly caused by a combination of two factors: the failure of insulin secretion by the pancreatic β-cells and the inability of insulin-sensitive ...
Elis Susilawati +3 more
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MYOCARDIAL FIBROSIS IN PATIENTS WITH DIABETES MELLITUS
Рациональная фармакотерапия в кардиологии, 2015 The mechanism of myocardial damage in diabetes mellitus is considered. The pathogenesis of myocardial fibrosis, leading to diabetic cardiomyopathy, is described in details.
O. M. Drapkina, B. B. Gegenava
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PPARgamma: A Potential Intrinsic and Extrinsic Molecular Target for Breast Cancer Therapy
Biomedicines, 2021 Over the last decades, the breast tumor microenvironment (TME) has been increasingly recognized as a key player in tumor development and progression and as a promising prognostic and therapeutic target for breast cancer patients.
Giuseppina Augimeri, Daniela Bonofiglio
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Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial [PDF]
Diabetes & Metabolism JournalBackground This study investigated the efficacy and safety of pioglitazone 30 mg/day add-on to inadequately controlled type 2 diabetes mellitus (T2DM) patients with treatment of dapagliflozin and metformin.
Jun Hwa Hong +12 more
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Medicina, 2023 Objectives: Studies have shown that people with diabetes have a high risk of osteoporosis and fractures. The effect of diabetic medications on bone disease cannot be ignored.
Ru-Dong Chen +6 more
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Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches
Angewandte Chemie International Edition, EarlyView.To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to analyse changes in the utilization, expenditure and average cost of noninsulin glucose‐lowering drugs (GLDs) between 2008 and 2023. Methods This was a retrospective observational study of 2008–2023 data from the National Medicaid State Drug Utilization database.
Rawan O. Almadfaa
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Cancer Biology and Prevention in Diabetes
Cells, 2020 The available evidence suggests a complex relationship between diabetes and cancer. Epidemiological data suggest a positive correlation, however, in certain types of cancer, a more complex picture emerges, such as in some site-specific cancers being ...
Swayam Prakash Srivastava +1 more
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