Results 11 to 20 of about 24,744 (229)

DPP4i, thiazolidinediones, or insulin and risks of cancer in patients with type 2 diabetes mellitus on metformin–sulfonylurea dual therapy with inadequate control

BMJ Open Diabetes Research & Care, 2020
Introduction This study aims to compare the risks of cancer among patients with type 2 diabetes mellitus (T2DM) on metformin–sulfonylurea dual therapy intensified with dipeptidyl peptidase 4 inhibitors (DPP4i), thiazolidinediones, or insulin.Research ...
Esther W Y Chan, Emily T Y Tse, Cindy L K Lam   +2 more
doaj   +1 more source

Comparison of glucagon-like peptide-1 receptor agonists and thiazolidinediones on treating nonalcoholic fatty liver disease: A network meta-analysis [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims Previous studies have revealed that glucagon-like peptide-1 receptor agonist (GLP-1RA) and thiazolidinedione (TZD) can improve nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).
Min Jeong Park, Hayeon Kim, Myeong Gyu Kim, Kyungim Kim   +3 more
doaj   +1 more source

Pharmacogenomics of Type 2 Diabetes Mellitus; A Step Toward Personalized Medicine

NUST Journal of Natural Sciences, 2021
Type 2 diabetes is a complex multifactorial disease characterized by insufficient insulin secretion and insulin resistance. Global prevalence of diabetes is increasing day by day making diabetes a global epidemic.
Asima Zia, Attya Bhatti, Peter John, Aysha Kiani   +3 more
doaj   +1 more source

Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

PLoS ONE, 2014
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the ...
Dongfeng Zhao, Zhenqi Shi, Amy H Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng   +6 more
doaj   +1 more source

Association between colorectal cancer and thiazolidinediones administration in a case-control study

BioMedicine, 2019
Objectives: This study was designed to assess whether there was an association between colorectal cancer and thiazolidinediones use. Methods: A population-based case-control study was performed using the database of the Taiwan National Health ...
Liao Kuan-Fu, Lin Cheng-Li, Lai Shih-Wei
doaj   +1 more source

Thiazolidinedione Derivatives: In Silico, In Vitro, In Vivo, Antioxidant and Anti-Diabetic Evaluation

Molecules, 2022
This work aimed to synthesize a new antihyperglycemic thiazolidinedione based on the spectral data. The DFT\B3LYP\6-311G** level of theory was used to investigate the frontier molecular orbitals (FMOs), chemical reactivity and map the molecular ...
Manal Y. Sameeh, Manal M. Khowdiary, Hisham S. Nassar, Mahmoud M. Abdelall, Hamada H. Amer, Abdelaaty Hamed, Ahmed A. Elhenawy   +6 more
doaj   +1 more source

Clinical effect of thiazolidinediones in subjects with disorders of carbohydrate metabolism in case of polymorphism rs1801282

Ожирение и метаболизм, 2020
BACKGROUND: The polymorphism rs1801282 (Pro12Ala) may be one of the reasons for the heterogeneous response of patients with carbohydrate metabolism disorders to thiazolidinedione therapy.
Tatyana V. Eremenko, Nikolay A. Matsievskiy, Natalya V. Vorokhobina, Irina Y. Matesius, Irina N. Abramashvili   +4 more
doaj   +1 more source

Pharmacogenetics of Anti-Diabetes Drugs

Pharmaceuticals, 2010
A variety of treatment modalities exist for individuals with type 2 diabetes mellitus (T2D). In addition to dietary and physical activity interventions, T2D is also treated pharmacologically with nine major classes of approved drugs.
Johanna K. DiStefano, Richard M. Watanabe   +1 more
doaj   +1 more source

Daily Intraperitoneal Administration of Rosiglitazone Does Not Improve Lung Function or Alveolarization in Preterm Rabbits Exposed to Hyperoxia

Pharmaceutics, 2022
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia.
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen   +21 more
doaj   +1 more source

Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors

Memorias do Instituto Oswaldo Cruz, 2013
Live attenuated vaccines have recently been introduced for preventing rotavirus disease in children. However, alternative strategies for prevention and treatment of rotavirus infection are needed mainly in developing countries where low vaccine coverage ...
Carlos Arturo Guerrero, Victor Rodriguez Paula Pardo, Orlando Acosta Rafael Guerrero   +2 more
doaj   +1 more source