Results 11 to 20 of about 24,637 (218)

DPP4i, thiazolidinediones, or insulin and risks of cancer in patients with type 2 diabetes mellitus on metformin–sulfonylurea dual therapy with inadequate control

BMJ Open Diabetes Research & Care, 2020
Introduction This study aims to compare the risks of cancer among patients with type 2 diabetes mellitus (T2DM) on metformin–sulfonylurea dual therapy intensified with dipeptidyl peptidase 4 inhibitors (DPP4i), thiazolidinediones, or insulin.Research ...
Esther W Y Chan, Emily T Y Tse, Cindy L K Lam   +2 more
doaj   +1 more source

Daily Intraperitoneal Administration of Rosiglitazone Does Not Improve Lung Function or Alveolarization in Preterm Rabbits Exposed to Hyperoxia

Pharmaceutics, 2022
Thiazolidinediones (TZDs) are potent PPARγ agonists that have been shown to attenuate alveolar simplification after prolonged hyperoxia in term rodent models of bronchopulmonary dysplasia.
Giorgio Aquila, Yannick Regin, Xabier Murgia, Fabrizio Salomone, Costanza Casiraghi, Chiara Catozzi, Enrica Scalera, Matteo Storti, Francesca Stretti, Giancarlo Aquino, Giorgia Cavatorta, Roberta Volta, Carmelina Di Pasquale, Caterina Amato, Fabio Bignami, Davide Amidani, Barbara Pioselli, Elisa Sgarbi, Paolo Ronchi, Giuseppe Mazzola, Ignacio Valenzuela, Jaan Toelen   +21 more
doaj   +1 more source

Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

PLoS ONE, 2014
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the ...
Dongfeng Zhao, Zhenqi Shi, Amy H Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng   +6 more
doaj   +1 more source

The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes

Biomolecules, 2022
The number of patients with type 2 diabetes mellitus (T2DM), which is mainly characterized by insulin resistance and insulin secretion deficiency, has been soaring in recent years.
Xiaohui Ji, Wenqian Zhang, Liqin Yin, Zunhan Shi, Jinwen Luan, Linshan Chen, Longhua Liu   +6 more
doaj   +1 more source

Association between colorectal cancer and thiazolidinediones administration in a case-control study

BioMedicine, 2019
Objectives: This study was designed to assess whether there was an association between colorectal cancer and thiazolidinediones use. Methods: A population-based case-control study was performed using the database of the Taiwan National Health ...
Liao Kuan-Fu, Lin Cheng-Li, Lai Shih-Wei
doaj   +1 more source

Effects of Thiazolidinedione and New Antidiabetic Agents on Stroke [PDF]

Journal of Stroke, 2019
Patients with hyperglycemia are at a high risk of cardio- and cerebrovascular diseases. Diabetes patients also have poor outcomes after cerebrovascular disease development.
Chang Ho Ahn, Soo Lim
doaj   +1 more source

Adsorption Mechanism of Eco-Friendly Corrosion Inhibitors for Exceptional Corrosion Protection of Carbon Steel: Electrochemical and First-Principles DFT Evaluations

Metals, 2022
In the present work, we represent two thiazolidinediones, namely (Z)-5-(4-methoxybenzylidene) thiazolidine-2,4-dione (MeOTZD) and (Z)-5-(4-methylbenzylidene) thiazolidine-2,4-dione (MeTZD), as corrosion inhibitors for carbon steel (CS) in 1.0 M HCl ...
Abdelkarim Chaouiki, Maryam Chafiq, Young Gun Ko, Aisha H. Al-Moubaraki, Fatima Zahra Thari, Rachid Salghi, Khalid Karrouchi, Khalid Bougrin, Ismat H. Ali, Hassane Lgaz   +9 more
doaj   +1 more source

Cancer Biology and Prevention in Diabetes

Cells, 2020
The available evidence suggests a complex relationship between diabetes and cancer. Epidemiological data suggest a positive correlation, however, in certain types of cancer, a more complex picture emerges, such as in some site-specific cancers being ...
Swayam Prakash Srivastava, Julie E. Goodwin   +1 more
doaj   +1 more source

Crosstalk between PPARγ Ligands and Inflammatory-Related Pathways in Natural T-Regulatory Cells from Type 1 Diabetes Mouse Model

Biomolecules, 2018
Immunomodulation, as a means of immunotherapy, has been studied in major research and clinical laboratories for many years. T-Regulatory (Treg) cell therapy is one of the modulators used in immunotherapy approaches. Similarly, nuclear receptor peroxisome
S. Zulkafli Nor Effa, Nik Soriani Yaacob, Norazmi Mohd Nor   +2 more
doaj   +1 more source

Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism

Journal of Lipid Research, 2004
Peroxisome proliferator-activated receptor γ (PPARγ) activation or overexpression induces caveolin-1 (cav-1) expression in several cell types. The objective of this study was to investigate if PPAR agonists could also regulate the cav-1 gene in ...
Gemma Llaverias, Manuel Vázquez-Carrera, Rosa M. Sánchez, Véronique Noé, Carlos J. Ciudad, Juan C. Laguna, Marta Alegret   +6 more
doaj   +1 more source