Results 71 to 80 of about 1,125,240 (316)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Journal of Government and EconomicsIt is a widely observed fact that after industrialization, the size of the government has increased significantly. This is often referred to as Wagner’s Law. Since the early twentieth century, it grew from around 10% to the current global average of 35%.
Bing Li, Daokui Li, Keaobo Li
doaj +1 more source
Thinking about the un-thinking [PDF]
Advances in Health Sciences Education, 2015 This issue could almost lay claim to being a special issue about all those things that aren’t supposed to matter in learning but do. Although emotions and interpersonal skills have been recognized as an essential component of competence for any health professional, they are rarely integrated into an overall perspective on the what and how of learning ...
openaire +2 more sources
Thinking about Thinking as Rational Computation
, 2023 Theory of Mind enables us to attribute mental states to others. But we not only make inferences about mental states (like what someone believes or wants), but about mental processes (like if someone is distracted or whether they remember something). Here, we present a computational formalization of these kinds of inferences.
Marlene Berke +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
, 2008 paradigm shift requires a new way of thinking about a problem. Service Oriented A rchitectures SOA s) represent a new approach to how systems are built.
Thinking Service Orienteda
core
A decade of dengue disease burden in Africa (2013–2023): a systematic review
Travel Medicine and Infectious DiseaseBackground: Dengue is a major mosquito-borne disease worldwide. The epidemiological trends of the disease in Africa over the past decade remain unclear. This review aims to provide insight into the epidemiological trends of dengue in Africa from 2013 to ...
Gaspary O. Mwanyika +8 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Refining an understanding of computational thinking
, 2014 This paper identifies aspects of computational thinking and proposes a description that meets the needs of teachers and academics reflecting upon the developing UK curriculum.
Woollard, John, Selby, Cynthia
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source