Results 61 to 70 of about 3,270,037 (174)

Alcoholic polyneuropathy: ways of diagnostics and therapy

Медицинский совет, 2019
The article is devoted to the analysis of the pathogenetic mechanisms of the formation of alcoholic lesions of the peripheral nervous system. Various clinical forms of alcoholic polyneuropathy are considered, ways to diagnose using modern instrumental ...
O. V. Kurushina, A. E. Barulin, E. P. Chernovolenko   +2 more
doaj   +1 more source

Efficacy and Safety of Pregabalin and Alpha‐Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open‐Label, Non‐Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 6172-6183, July 2026.
ABSTRACT Aims To assess the efficacy and safety of alpha‐lipoic acid (ALA) and pregabalin, both as mono and combination therapy, for treating painful diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus, with the hypothesis that pregabalin monotherapy is non‐inferior to combination therapy.
Tae Jung Oh, Sang Soo Kim, Seung‐Hwan Lee, Hyuk‐Sang Kwon, Eun Sook Kim, Eun‐Jung Rhee, Hye Jin Yoo, Han Na Jang, Woo Je Lee, Eun Sook Kim, Sang Yong Kim, Gwanpyo Koh, Eun‐Gyoung Hong, Tae Sun Park, Jong Chul Won   +14 more
wiley   +1 more source

Surface Structure and Chemical Switching of Thioctic Acid Adsorbed on Au(111) As Observed Using Near-Edge X-ray Absorption Fine Structure

, 2016
Thioctic acid (α-lipoic acid) is a molecule with a large disulfide-containing base, a short alkyl chain with four CH2 units, and a carboxyl termination. Self-assembled monolayer (SAM) films of thioctic acid adsorbed on Au(111) have been investigated with
Trevor M. Willey (1410319), Christoph Bostedt (1416331), Andrew L. Vance (1266114), Louis J. Terminello (1953634), Robert W. Meulenberg (1453846), Tony van Buuren (1840822), Charles S. Fadley (2715691)   +6 more
core   +4 more sources

Stimuli‐Responsive Poly(Disulfide)s: A Versatile Platform for Intelligent Drug Delivery Systems

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Ring‐opening polymerization based on dynamic disulfide bond exchange is an important method for synthesizing poly(disulfide)s. These polymers possess stimulus‐responsive mechanisms and show broad prospects in intelligent drug delivery. This review systematically discusses the ring‐opening polymerization strategy and research progress of drug delivery ...
Yuechen He, Qiuhong Ouyang, Xinglv Chen, Qian Zhong, Xunhuan Song, Yujie Sun, Bingran Yu, Meng Qin   +7 more
wiley   +1 more source

Clinical Approaches to the Treatment of Diabetic Neuropathy

Mìžnarodnij Endokrinologìčnij Žurnal, 2014
The article is devoted to the treatment of diabetic neuropathy. The described scheme of application of preparations of alpha-lipoic (thioctic) acid. Recently in Europe and the United States conducted a series of clinical studies that have shown that the ...
A.V. Kaminsky
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Metabolism of Thioctic Acid in Algae [PDF]

, 1956
Thioctic acid labeled with sulfur-35 has been prepared and i t s metabolism b y algae has been studied. It i s converted by the algae into a number of forms, all of which upon hydrolysis yield either the disulfide o r i t s sulfoxide.
Grisebach, Hans, Fuller, R C, Calvin, M., Fuller, R.C., Calvin, M   +4 more
core   +1 more source

Study of pharmaco-technological properties of solid dispersions of thioctic acid obtained by micronization method

Annals of Mechnikov's Institute, 2018
Introduction. Thioctic acid is used in the treatment of diseases that are characterized by lack of mitochondrial activity, which is responsible for the formation of free radicals. Widespread use of thioctic acid is due to the chemical structure.
I Kovalevska, O Ruban
doaj  

Drug utilisation trends in a physical rehabilitation hospital [PDF]

Vojnosanitetski Pregled, 2019
Background/Aim. Drug utilisation monitoring could identify drug-related problems and hence improve the awareness of irrational drug use. The objective of this study was to analyse the drug utilisation patterns in a rehabilitation hospital over the period
Ljubojević Gordana, Mastikosa Milan, Dostanić-Došenović Tanja, Novaković-Bursać Snježana, Tomić Nataša, Talić Goran, Škrbić Ranko, Stojiljković Miloš P.   +7 more
doaj   +1 more source

Thioctic acid modification of oligonucleotides using an H-phosphonate

, 2010
The H-phosphonate of a derivative of thioctic acid (TA) was synthesized and used to introduce a disulfide moiety at the 5'-end of oligonucleotides. This method overcomes the difficulties experienced with the phosphoramidite approach when employing a ...
Graham, Duncan, Reid, Andrew K., Dougan, Jennifer A.   +2 more
core   +3 more sources