Results 91 to 100 of about 427,077 (192)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Probiotic Spore Inspired Oral Drug Delivery System With Multiple‐Barriers‐Crossing Ability Modulates Gut‐Brain Axis for Parkinson's Disease Therapy

Exploration, EarlyView.
Inspired by the germination of probiotic spores, we utilize the excellent characteristics of spores to break through multiple barriers of oral brain‐targeted delivery. Besides the probiotics mediated gut‐brain communication, the spore coat proteins derived nanosystems with multiple‐barriers‐crossing ability alleviate neurodegeneration.
Qianhua Feng, Yuying Mei, Jia Zhang, Liying Sun, Bingqian Si, Huimin Zhou, Huifang Xiao, Runhan Liu, Jieyun Zhang, Lei Wang   +9 more
wiley   +1 more source

Association of thiol disulfide homeostasis with slow coronary flow

, 2016
Objective The aim of this study was to investigate the role of thiol disulfide homeostasis in the presence of slow coronary flow. Material and methods In this cross-sectional study, a total of 110 patients who admitted to our hospital between March 2014 ...
EREL, ÖZCAN, Kiziltunc, EMRULLAH, Ulusoy, Feridun Vasfi, Cetin, Mustafa, Topcuoglu, Canan, NEŞELİOĞLU, SALİM, Kundi, Harun, Gok, Murat   +7 more
core   +1 more source

Dynamic changes in thiol–disulfide homeostasis and oxidative stress during vincristine treatment in Kangal bitches with transmissible venereal tumor

Revista Científica
The aim of this study was to evaluate time-dependent changes in oxidative stress biomarkers and thiol-disulfide homeostasis in dogs diagnosed with canine transmissible venereal tumor and treated with vincristine sulfate. Eighteen female Kangal dogs were
Murat Can Demir, Mushap Kuru, Mustafa Makav, Emin Karakurt, Merve Sena Demir, Burak Büyükbaki, Semra Kaya   +6 more
doaj  

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Dynamic thiol-disulfide homeostasis in acute ischemic stroke patients

, 2016
Dynamic thiol-disulfide homeostasis plays a critical role in the cellular protection provided by antioxidation. The aim of this study was to investigate whether there is a change in thiol-disulfide homeostasis in acute ischemic stroke patients.
Alisik, Murat, EREL, ÖZCAN, Bektas, HESNA, DENİZ, ORHAN, VURAL, GÖNÜL, GÜMÜŞYAYLA, ŞADİYE   +5 more
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Thiol-disulfide homeostasis: An integrated approach with biochemical and clinical aspects

, 2020
Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-).
EREL, ÖZCAN, Erdoğan, Serpil
core   +1 more source

Thiol/Disulfide Homeostasis as an Early Biomarker to Differentiate Sepsis from Pneumonia in Intensive Care Units

, 2021
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND: It is possible that patients with pneumonia may also have sepsis and the separation of these two clinical entities may cause some trouble to ...
EREL, ÖZCAN, Cakir, Esra, Turan, Isil Ozkocak, Gok, Gamze   +3 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source