Results 271 to 280 of about 114,000 (315)
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Mini-Reviews in Medicinal Chemistry, 2007
Various classes of cytotoxic compounds which alkylate cellular thiols are described namely alpha,beta-unsaturated ketones, alpha-methylene-gamma-lactones, azines of Mannich bases, imexon, isothiocyanates, a benzoacronycine as well as activation by thiols prior to alkylation.
Hari N, Pati +3 more
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Various classes of cytotoxic compounds which alkylate cellular thiols are described namely alpha,beta-unsaturated ketones, alpha-methylene-gamma-lactones, azines of Mannich bases, imexon, isothiocyanates, a benzoacronycine as well as activation by thiols prior to alkylation.
Hari N, Pati +3 more
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Reaction of alkylcobalamins with thiols
Biochemistry, 1987Carbon-13 NMR spectroscopy and phosphorus-31 NMR spectroscopy have been used to study the reaction of several alkylcobalamins with 2-mercaptoethanol. At alkaline pH, when the thiol is deprotonated, the alkyl-transfer reactions involve a nucleophilic attack of the thiolate anion on the Co-methylene carbon of the cobalamins, yielding alkyl thioethers and
H P, Hogenkamp +2 more
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Thiols as peroxidase substrates
Free Radical Biology and Medicine, 1993The abilities of haem peroxidases to catalyse the oxidation of various thiols were studied using the spin-trapping electron spin resonance (ESR) technique. Myeloperoxidase, a neutrophil and monocyte enzyme, catalysed the oxidation of cysteamine, cysteine methyl, and ethyl ester and to some extent 2-mercaptoethanol and thioglycollic acid.
B E, Svensson +3 more
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Comparative Biochemistry and Physiology, 1965
Abstract 1. 1. The total sulfhydryl groups and the number of free SH groups of hemocyanins from different sources has been determined. Hemocyanins are well characterized by their content of “half cystine”, much more than by the content of any other amino acid. 2. 2.
A, Ghiretti-Magaldi, C, Nuzzolo
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Abstract 1. 1. The total sulfhydryl groups and the number of free SH groups of hemocyanins from different sources has been determined. Hemocyanins are well characterized by their content of “half cystine”, much more than by the content of any other amino acid. 2. 2.
A, Ghiretti-Magaldi, C, Nuzzolo
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Artificial Organs, 1979
ABSTRACTThe plasma concentrations of methane and ethane thiols have been determined during the course of acute liver failure by a gas‐chromatographic technique, and a prognostic evaluation is possible using this analysis. Further, the effects of some therapeutic measures, notably hemoperfusion, on the thiol levels have been investigated.
C J, Holloway +3 more
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ABSTRACTThe plasma concentrations of methane and ethane thiols have been determined during the course of acute liver failure by a gas‐chromatographic technique, and a prognostic evaluation is possible using this analysis. Further, the effects of some therapeutic measures, notably hemoperfusion, on the thiol levels have been investigated.
C J, Holloway +3 more
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Thiols and the chemoprevention of cancer
Current Opinion in Pharmacology, 2007Thiols such as glutathione interfere with the complex carcinogenic process. Under stress conditions, they scavenge harmful molecules: Glutathione conjugation of electrophilic carcinogens may prevent tumor initiation, and reduced thiols may defend against oxidative stress. Thus, associated chemopreventive strategies involve enhancement of antioxidant or
Wolfgang W, Huber, Wolfram, Parzefall
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THE REDUCTION OF ADRENOCHROME WITH THIOLS
Canadian Journal of Biochemistry and Physiology, 1959Null
R A, HEACOCK, B D, SCOTT
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Nature, 1959
WE have recently shown1,2 that β-mercaptoethanol (a strongly reducing –SH-containing substance) markedly inhibits morphogenetic movements (gastrulation, closure of neural plate) in amphibian eggs. The oxidized counterpart of β-mercaptoethanol (dithiodiglycol) produces a thickening of the neural plate; the same type of abnormalities can be obtained with
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WE have recently shown1,2 that β-mercaptoethanol (a strongly reducing –SH-containing substance) markedly inhibits morphogenetic movements (gastrulation, closure of neural plate) in amphibian eggs. The oxidized counterpart of β-mercaptoethanol (dithiodiglycol) produces a thickening of the neural plate; the same type of abnormalities can be obtained with
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Nature, 1957
A NEW thiol has been found in the red kidney bean, Phaseolus vulgaris, and in certain other legumes. The thiol is the principal non-protein thiol of these plants. Glutathione, when present, occurs at much lower concentrations. A provisional name, ‘phaseothione’, has been assigned to this compound, pending the determination of its chemical structure.
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A NEW thiol has been found in the red kidney bean, Phaseolus vulgaris, and in certain other legumes. The thiol is the principal non-protein thiol of these plants. Glutathione, when present, occurs at much lower concentrations. A provisional name, ‘phaseothione’, has been assigned to this compound, pending the determination of its chemical structure.
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Journal of Ocular Pharmacology and Therapeutics, 2000
The high content of glutathione (GSH) in the lens is believed to protect the thiols in structural proteins and enzymes for proper biological functions. The lens has both biosynthetic and regenerating systems for GSH to maintain its large pool size (4-6 mM).
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The high content of glutathione (GSH) in the lens is believed to protect the thiols in structural proteins and enzymes for proper biological functions. The lens has both biosynthetic and regenerating systems for GSH to maintain its large pool size (4-6 mM).
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