Results 281 to 290 of about 182,890 (341)
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Thiol-dependent and non-thiol-dependent stimulations of insulin release
Diabetes, 1984The effects of reduced glutathione (GSH) and diamide (an oxidant of GSH) on insulin release induced by glucose, glyceraldehyde, leucine, tolbutamide, glibenclamide, Ca-ionophore A-23187, isoprenaline, and db-cAMP were studied using isolated rat pancreatic islets.
H P, Ammon +3 more
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Mini-Reviews in Medicinal Chemistry, 2007
Various classes of cytotoxic compounds which alkylate cellular thiols are described namely alpha,beta-unsaturated ketones, alpha-methylene-gamma-lactones, azines of Mannich bases, imexon, isothiocyanates, a benzoacronycine as well as activation by thiols prior to alkylation.
Hari N, Pati +3 more
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Various classes of cytotoxic compounds which alkylate cellular thiols are described namely alpha,beta-unsaturated ketones, alpha-methylene-gamma-lactones, azines of Mannich bases, imexon, isothiocyanates, a benzoacronycine as well as activation by thiols prior to alkylation.
Hari N, Pati +3 more
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Reaction of alkylcobalamins with thiols
Biochemistry, 1987Carbon-13 NMR spectroscopy and phosphorus-31 NMR spectroscopy have been used to study the reaction of several alkylcobalamins with 2-mercaptoethanol. At alkaline pH, when the thiol is deprotonated, the alkyl-transfer reactions involve a nucleophilic attack of the thiolate anion on the Co-methylene carbon of the cobalamins, yielding alkyl thioethers and
H P, Hogenkamp +2 more
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Thiols as peroxidase substrates
Free Radical Biology and Medicine, 1993The abilities of haem peroxidases to catalyse the oxidation of various thiols were studied using the spin-trapping electron spin resonance (ESR) technique. Myeloperoxidase, a neutrophil and monocyte enzyme, catalysed the oxidation of cysteamine, cysteine methyl, and ethyl ester and to some extent 2-mercaptoethanol and thioglycollic acid.
B E, Svensson +3 more
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Thiols and the chemoprevention of cancer
Current Opinion in Pharmacology, 2007Thiols such as glutathione interfere with the complex carcinogenic process. Under stress conditions, they scavenge harmful molecules: Glutathione conjugation of electrophilic carcinogens may prevent tumor initiation, and reduced thiols may defend against oxidative stress. Thus, associated chemopreventive strategies involve enhancement of antioxidant or
Wolfgang W, Huber, Wolfram, Parzefall
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Nature, 1959
WE have recently shown1,2 that β-mercaptoethanol (a strongly reducing –SH-containing substance) markedly inhibits morphogenetic movements (gastrulation, closure of neural plate) in amphibian eggs. The oxidized counterpart of β-mercaptoethanol (dithiodiglycol) produces a thickening of the neural plate; the same type of abnormalities can be obtained with
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WE have recently shown1,2 that β-mercaptoethanol (a strongly reducing –SH-containing substance) markedly inhibits morphogenetic movements (gastrulation, closure of neural plate) in amphibian eggs. The oxidized counterpart of β-mercaptoethanol (dithiodiglycol) produces a thickening of the neural plate; the same type of abnormalities can be obtained with
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Journal of Ocular Pharmacology and Therapeutics, 2000
The high content of glutathione (GSH) in the lens is believed to protect the thiols in structural proteins and enzymes for proper biological functions. The lens has both biosynthetic and regenerating systems for GSH to maintain its large pool size (4-6 mM).
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The high content of glutathione (GSH) in the lens is believed to protect the thiols in structural proteins and enzymes for proper biological functions. The lens has both biosynthetic and regenerating systems for GSH to maintain its large pool size (4-6 mM).
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Annual Review of Microbiology, 2001
▪ Abstract Glutathione metabolism is associated with oxygenic cyanobacteria and the oxygen-utilizing purple bacteria, but is absent in many other prokaryotes. This review focuses on novel thiols found in those bacteria lacking glutathione. Included are glutathione amide and its perthiol, produced by phototrophic purple sulfur bacteria and apparently ...
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▪ Abstract Glutathione metabolism is associated with oxygenic cyanobacteria and the oxygen-utilizing purple bacteria, but is absent in many other prokaryotes. This review focuses on novel thiols found in those bacteria lacking glutathione. Included are glutathione amide and its perthiol, produced by phototrophic purple sulfur bacteria and apparently ...
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Formation of monolayer films by the spontaneous assembly of organic thiols from solution onto gold
, 1989C. D. Bain +5 more
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2001
The thiol redox status of intracellular and extracellular compartments is critical in the determination of protein structure, regulation of enzyme activity, and control of transcription factor activity and binding. Thiol antioxidants act through a variety of mechanisms, including (1) as components of the general thiol/disulfide redox buffer, (2) as ...
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The thiol redox status of intracellular and extracellular compartments is critical in the determination of protein structure, regulation of enzyme activity, and control of transcription factor activity and binding. Thiol antioxidants act through a variety of mechanisms, including (1) as components of the general thiol/disulfide redox buffer, (2) as ...
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