Results 31 to 40 of about 406 (117)
Synthesis of thiomers: screening and optimization using chemometrics
, 2018 A chemometric study of the processing variables involved in the synthesis of thiomers based on poly(acrylic acid) functionalized with l-cysteine (PAA-cys) mediated by carbodiimide was successfully carried out.
Víctor H. Campos-Requena, Samuel Gómez
core +1 more source
Design of novel drug delivery systems providing a prolonged mucosal residence time
, 2016 > Ziel dieser Arbeit war es, die Schleimhautverweilzeit von Wirkstoffabgabesystemen zu verlängern. Hierfür wurden zwei Strategien entwickelt, thiolysierte Polymer oder Thiomere und Zeta-Potenzial-verändernde Nanocarrier.
Suchaoin, Wongsakorn
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Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, Volume 35, Issue 35, August 28, 2025.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 The efficient noninvasive treatment of neurodegenerative disorders is often constrained by reduced permeation of therapeutic agents into the central nervous system (CNS). A vast majority of bioactive agents do not readily permeate into the brain tissue due to the existence of the blood‐brain barrier (BBB) and the associated P‐glycoprotein efflux ...
Famida G. Hoosain +7 more
wiley +1 more source
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
BioMed Research International, Volume 2015, Issue 1, 2015., 2015 Infectious stomatitis represents the most common oral cavity ailments. Current therapy is insufficiently effective because of the short residence time of topical liquid or semisolid medical formulations. An innovative application form based on bioadhesive polymers featuring prolonged residence time on the oral mucosa may be a solution to this challenge.
Jan Gajdziok +7 more
wiley +1 more source
Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing
Advanced Functional Materials, Volume 34, Issue 4, January 22, 2024.By thiolation of poly‐ and oligosaccharides numerous favorable properties for tissue engineering and wound healing can be introduced. Within this review an overview about the chemistry of thiolated poly‐ and oligosaccharides, their key properties, applications and performance in clinical trials and as marketed products is provided.
Sobia Noreen +1 more
wiley +1 more source
Thiomers: A Blessing to Evaluating Era of Pharmaceuticals
, 2020 Thiomers are the polymers modified for the mucoadhesive properties and other additive properties by incorporating thiol moieties in the backbone of the unmodified polymeric chain by substitution reactions or simple oxidation reactions.
Muhammad Hanif +2 more
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Synthesis and screening of N-acyl thiolated chitosans for antibacterial applications
, 2016 Low-molecular weight chitosan-thioglycolic acid has shown significant antibacterial properties against different microorganisms. In order to explore the potential and structure-activity relationships of newly synthesized alkyl thiomers, chitosan has been
Croce, Matteo +3 more
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How to avoid syringes by mucosal drug delivery : addressing the mucus gel layer
, 2018 Im Zuge dieser Arbeit wurden die beiden unterschiedlichen Strategien der Mukoadhäsion und der Mukuspermeation angewendet, um die Mukusbarriere zu überwinden und eine verbesserte Arzneimittelapplikation an der Schleimhaut zu erreichen.
Menzel, Claudia
core +4 more sources