Results 21 to 30 of about 406 (117)

Combination of Technologies : Thiomers and Self emulsifying drug delivery systems

, 2018
Kombination zweier Technologien: Thiomere und Selbstemulgierende WirkstoffabgabesystemeCombination of two different technologies: Thiomers and Self emulsifying drug delivery systemsvorgelegt von Sandra BetzAbweichender Titel laut Übersetzung der ...
Betz, Sandra
core   +3 more sources

Thiolated polymers: An overview of mucoadhesive properties and their potential in drug delivery via mucosal tissues

, 2023
Thiolated polymers, or thiomers, are a class of polymers that exhibit unique mucoadhesive properties, allowing them to form strong covalent bonds with cysteine-rich subdomains of mucus glycoproteins.
Yadollah Omidi, Mittal, Rahul, Rahul Mittal, Kwadwo Mfoafo, Adrien Eshraghi, Hossein Omidian, Mfoafo, Kwadwo, Eshraghi, Adrien, Omidi, Yadollah, Omidian, Hossein   +9 more
core   +1 more source

Bilayered Films Based on Novel Polymer Derivative for Improved Ocular Therapy of Gatifloxacin

The Scientific World Journal, 2014
Context. Thiomers could prove to be suitable mucoadhesives for fabrication of ocular inserts. Objective. The study intends to explore the application of thiolated sodium alginate (TSA) to the preparation of bilayered ocular inserts of gatifloxacin ...
Naval Dinesh Aher, Hema Ajit Nair
doaj   +1 more source

Complexation of novel thiomers and insulin to protect against in vitro enzymatic degradation – towards oral insulin delivery [PDF]

, 2019
A significant barrier to oral insulin delivery is its enzymatic degradation in the gut. Nano-sized polymer-insulin polyelectrolyte complexes (PECS) have been developed to protect insulin against enzymatic degradation.
C.J. Thompson (5786921), R.M. Knott (5786918), Ibie, C.O., Knott, R.M., Thompson, C.J., C.O. Ibie (5786915)   +5 more
core   +1 more source

Ultrahigh‐resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing

Acta Ophthalmologica, Volume 97, Issue 5, Page e761-e771, August 2019., 2019
Abstract Purpose To employ ultrahigh‐resolution (UHR) optical coherence tomography (OCT) for investigation of the early wound healing process in corneal epithelium. Methods A custom‐built UHR‐OCT system assessed epithelial healing in human keratoconic cornea after epi‐off crosslinking (CXL) procedure and a wound healing model in rabbits with iatrogenic
Anca Pantalon, Martin Pfister, Valentin Aranha dos Santos, Sabina Sapeta, Angelika Unterhuber, Niklas Pircher, Gerald Schmidinger, Gerhard Garhöfer, Doreen Schmidl, Leopold Schmetterer, René M. Werkmeister   +10 more
wiley   +1 more source

Solid Lipid Nanoparticles Based on L‐Cysteine for Progesterone Intravaginal Delivery

International Journal of Polymer Science, Volume 2019, Issue 1, 2019., 2019
The present work has as its purpose the synthesis and characterization of a novel lipid material to be used in the preparation of solid lipid nanoparticles (SLNs) for the potential sustained release of progesterone in the vagina. For this reason, a material capable of ensuring the permanence of the formulation in the administration site for the time ...
Roberta Cassano, Sonia Trombino, Christopher Batich   +2 more
wiley   +1 more source

Effect of Topically Administered Chitosan‐N‐acetylcysteine on Corneal Wound Healing in a Rabbit Model

Journal of Ophthalmology, Volume 2017, Issue 1, 2017., 2017
Purpose. The present study was performed to investigate the effect of topically administered chitosan‐N‐acetylcysteine (C‐NAC) on corneal wound healing in a rabbit model. Methods. A total of 20 New Zealand White rabbits were included in the randomized, masked, placebo‐controlled experiment.
Corinna Fischak, Robert Klaus, René M. Werkmeister, Christine Hohenadl, Martin Prinz, Leopold Schmetterer, Gerhard Garhöfer, Taras Ardan   +7 more
wiley   +1 more source

Engineering Oral Insulin Delivery: Nanomaterial Strategies to Overcome Gastrointestinal Barriers and Advance Clinical Translation

Journal of Nanotechnology, Volume 2026, Issue 1, 2026.
Diabetes mellitus is a chronic metabolic disease characterized by insufficient insulin production or action, resulting in impaired blood glucose regulation. Insulin therapy remains critical for managing diabetes; however, it is conventionally administered through regular subcutaneous injections.
Nontokozo Zimbili Msomi, Xin Xiao, Md. Shahidul Islam, Maoquan Chu, Munmun Bardhan   +4 more
wiley   +1 more source

Hyaluronan thiomer gel/matrix mediated healing of articular cartilage defects in New Zealand White rabbits—a pilot study

Journal of Experimental Orthopaedics, Volume 4, Issue 1, 2017., 2017
Abstract Background Articular cartilage defects are limited to their regenerative potential in human adults. Our current study evaluates tissue regeneration in a surgically induced empty defect site with hyaluronan thiomer as a provisional scaffold in a gel/matrix combination without cells on rabbit models to restore tissue formation.
Christoph Bauer, Vivek Jeyakumar, Eugenia Niculescu‐Morzsa, Daniela Kern, Stefan Nehrer   +4 more
wiley   +1 more source

Amino‐ and Thiol‐Functionalized Brewer's Spent Yeast Hydrolysates: Physicochemical and Antioxidant Properties

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
A significant by‐product of beer brewing is brewer's spent yeast (BSY), which is often discarded. In the present study, BSY valorization was conducted through hydrolysis with pepsin to obtain HBSY with varying degrees of hydrolysis. These hydrolysates were then thiolated and aminated using different reagents, including silanization, amidation, thiourea,
Elahe Abedi, Philip C. Wietstock, Brian Gibson   +2 more
wiley   +1 more source