Results 11 to 20 of about 406 (117)

Thiolated Mesoporous Silica Nanoparticles as an Immunoadjuvant to Enhance Efficacy of Intravesical Chemotherapy for Bladder Cancer. [PDF]

Adv Sci (Weinh), 2023
The nanovectors, mitomycin C (MMC)‐loaded, externally thiolated hollow mesoporous silica nanoparticles (MSN‐SH(E)), are confirmed to be helpful in promoting anticancer activity, holding the great potential for being used in intravesical therapy for non‐muscle invasive bladder cancer due to its mucoadhesivity, enhanced permeation, immunomodulation and ...
Chen CC, Fa YC, Kuo YY, Liu YC, Lin CY, Wang XH, Lu YH, Chiang YH, Yang CM, Wu LC, Ho JA.   +10 more
europepmc   +2 more sources

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body. [PDF]

Adv Sci (Weinh), 2022
Among the various properties of nanoparticles (NPs) that are used for biomedical applications are functionalities being related to thiol substructures. This review focuses on the interface between thiol chemistry and NPs and provides a concise summary of the current knowledge, future directions, and potential clinical use of thiolated NPs.
Hock N, Racaniello GF, Aspinall S, Denora N, Khutoryanskiy VV, Bernkop-Schnürch A.   +5 more
europepmc   +2 more sources

Less Reactive Thiol Ligands: Key towards Highly Mucoadhesive Drug Delivery Systems. [PDF]

Polymers (Basel), 2020
As less reactive s-protected thiomers can likely interpenetrate the mucus gel layer to a higher extent before getting immobilized via disulfide bond formation with mucins, it was the aim of this study to develop a novel type of s-protected thiomer based ...
Shahzadi I, Fürst A, Akkus-Dagdeviren ZB, Arshad S, Kurpiers M, Matuszczak B, Bernkop-Schnürch A.   +6 more
europepmc   +2 more sources

Journal of Controlled Release / Thiolated polymeric hydrogels for biomedical application: cross-linking mechanisms [PDF]

, 2021
This review focuses on the synthesis of hydrogel networks using thiomers such as thiolated hyaluronic acid, chitosan, cyclodextrin, poly(ethylene glycol) and dextran that are cross-linked via their thiol substructures.
Bernkop-Schnürch, A., Racaniello, G.F., Summonte, S., Lopedota, A., Denora, N.   +4 more
core   +2 more sources

Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route

Journal of Nanotechnology, Volume 2023, Issue 1, 2023., 2023
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid‐induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid carriers (NLCs) have emerged as a promising delivery carrier ...
Alok Kumar Mahor, Prem Prakash Singh, Rishikesh Gupta, Peeyush Bhardwaj, Priyanka Rathore, Ankita Kishore, Rohit Goyal, Neeraj Sharma, Jyoti Verma, Jessica M. Rosenholm, Kuldeep K. Bansal, Nasrullah Jan   +11 more
wiley   +1 more source

Hyaluronic Acid‐Based Injectable Hydrogels for Wound Dressing and Localized Tumor Therapy: A Review

Advanced NanoBiomed Research, Volume 2, Issue 12, December 2022., 2022
The recent notable efforts made on the use of hyaluronic acid‐based injectable hydrogels as wound dressings and localized tumor therapy with a focus on chemistry adopted to achieve desirable properties and functions are summarized. Hyaluronic acid (HA)‐based hydrogels are regarded as ideal candidates for wound dressing and localized cancer treatment ...
Xu Yang, Bin Wang, Dongdong Peng, Xiaobo Nie, Jun Wang, Cui-Yun Yu, Hua Wei   +6 more
wiley   +1 more source

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Advanced Materials Interfaces, Volume 9, Issue 18, June 22, 2022., 2022
Understanding mucoadhesion can lead to lifesaving technologies. In this review, the special adhesion mechanisms between polymers and mucosal tissues are reviewed with unique cases and examples on recent advances in interface materials, characterization, and technologies.
Ilker S. Bayer
wiley   +1 more source

Quantification of intrinsic optical signals in the outer human retina using optical coherence tomography

Annals of the New York Academy of Sciences, Volume 1510, Issue 1, Page 145-157, April 2022., 2022
Intrinsic optical signals constitute a noninvasive biomarker promising the objective assessment of retinal photoreceptor function. We employed a commercial optical coherence tomography (OCT) system and a dedicated OCT signal model for evaluation of optical path length changes in the temporal outer retina of five healthy subjects during light adaptation.
Alina Messner, Valentin Aranha dos Santos, Hannes Stegmann, Stefan Puchner, Doreen Schmidl, Rainer Leitgeb, Leopold Schmetterer, René M. Werkmeister   +7 more
wiley   +1 more source

Deep learning differentiates between healthy and diabetic mouse ears from optical coherence tomography angiography images

Annals of the New York Academy of Sciences, Volume 1497, Issue 1, Page 15-26, August 2021., 2021
We trained a deep learning algorithm to use skin optical coherence tomography angiograms of the ear to differentiate between healthy and type 2 diabetic mice. The deep learning classification algorithm uses a convolutional neural network architecture and was trained on small patches extracted from the full ear angiograms.
Martin Pfister, Hannes Stegmann, Kornelia Schützenberger, Bhavapriya Jasmin Schäfer, Christine Hohenadl, Leopold Schmetterer, Martin Gröschl, René M. Werkmeister   +7 more
wiley   +1 more source

Acta biomaterialia / Thiolated pectins: in vitro and ex vivo evaluation of three generations of thiomers

, 2021
In recent decades, three generations of thiomers have been developed with the main purpose of obtaining enhanced interactions with mucosal tissues.
Le, Nguyet-Minh Nguyen, Asim, Mulazim Hussain, Wibel, Richard, Baus, Randi Angela, Kali, Gergely, Knoll, Patrick, Bernkop-Schnürch, Andreas   +6 more
core   +1 more source