Results 11 to 20 of about 11,767 (116)

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source

Effect of an adjustable ceiling to prevent premature rising attempts after general anesthesia in healthy ponies and horses: A pilot study

Veterinary Surgery, EarlyView.
Abstract Objective This study aimed to assess and compare the recovery of ponies and horses following general anesthesia in two different settings: a recovery box with an inflexible, adjustable ceiling, and free recovery without restraints. Our primary objective was to evaluate the effect of adjustable ceilings on the prevention of premature attempts ...
Anna Lindqvist, Görel Nyman, Anneli Rydén, Ove Wattle   +3 more
wiley   +1 more source

Elevated cortisol concentration in preterm sheep fetuses impacts heart development

Experimental Physiology, EarlyView.
Abstract The prepartum rise in cortisol promotes cardiac development and maturation. Here, we investigated the impact of elevated circulating cortisol during mid‐late gestation on cardiac growth and metabolism in fetal sheep. Saline or cortisol (2–3 mg in 4.4 mL/24 h) was infused into the fetal jugular vein from 109 to 116 days gestation (dG, term ...
Reza Amanollahi, Stacey L. Holman, Melanie R. Bertossa, Ashley S. Meakin, Vicki L. Clifton, Kent L. Thornburg, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison   +9 more
wiley   +1 more source

Fructose‐Induced Impairment of Liver and Skeletal Muscle Metabolism Is Prevented by Administration of Shouchella clausii Spores by Preserving Mitochondrial Function and Insulin Sensitivity

Molecular Nutrition &Food Research, Volume 69, Issue 11, June 2025.
S. clausii SF174 spores were effective in preventing the onset of low‐grade inflammation and insulin resistance induced by fructose‐rich diet in young rats, preserving the mitochondria from changes in the respiratory capacity in both liver and skeletal muscle, maintaining unaltered the oxidative balance, thus counteracting the deleterious effects of ...
Angela Di Porzio, Valentina Barrella, Anella Saggese, Loredana Baccigalupi, Luisa Cigliano, Ezio Ricca, Susanna Iossa, Arianna Mazzoli   +7 more
wiley   +1 more source

In Vivo Quantification of Creatine Kinase Kinetics in Mouse Brain Using 31P‐MRS at 7 T

NMR in Biomedicine, Volume 38, Issue 6, June 2025.
We demonstrate the feasibility of using 31P‐MRS to quantify creatine kinase activity in the mouse brain on preclinical 7‐T scanners. A 20% drop in respiration increased the apparent forward rate constant by 36%, likely due to altered pH and mitochondrial ATP production.
Mohamed Tachrount, Sean Smart, Jason Lerch, Antoine Cherix   +3 more
wiley   +1 more source

Colo‐Protective Effects of Pentoxifylline Alone or in Combination With Mesalamine in Colitis Through Sphingosine Kinase 1/Sphingosine 1 Phosphate, and Zonula Occuldin 1 Pathways: New Molecular Approach

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Multiple signaling pathways have been implicated in the pathogenesis of ulcerative colitis (UC), including Sphingosine Kinase 1 (SPHK)/Sphingosine‐1‐Phosphate (S1P), AMP‐activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/NLR family pyrin domain‐containing 3 (NLRP3), zonula occludens‐1 (ZO‐1), and signal transducer and ...
Fatemah A. Alherz, Mahmoud S. Abdallah, Esraa M. Mosalam, Mostafa M. Bahaa, Thanaa A. Elmasry, Mohamad A. El‐Gammal, Walaa A. Negm, AyaIbrahim Elberri, Nora Elshorbagi, Hend E. Abo Mansour, Amir O. Hamouda, Muhammed M. Salahuddin, Mohamed Yasser, Mamdouh Eldesoqui, Sarah Alrubia, Amsha S. Alsegiani, Eman El‐Khateeb, Mohamed Kh. ElMahdy, Eman Wahsh   +18 more
wiley   +1 more source

Best practices for blood collection and anaesthesia in mice: Selection, application and reporting

British Journal of Pharmacology, Volume 182, Issue 11, Page 2337-2353, June 2025.
Abstract Blood collection in mice is a common procedure in biomedical research. The choice of blood collection method and the need for analgesia and/or anaesthesia depend on multiple factors, including the experimental setup, animal welfare considerations and the intended downstream analyses.
Zhixin Li, Anthea LoBue, Sophia K. Heuser, Junjie Li, Eva Engelhardt, Andreas Papapetropoulos, Hemal H. Patel, Elliot Lilley, Péter Ferdinandy, Rainer Schulz, Miriam M. Cortese‐Krott   +10 more
wiley   +1 more source

Assessment of Sedative Activity of Lonicerin: In Vivo Approach With Pharmacokinetics and Molecular Docking

Brain and Behavior, Volume 15, Issue 5, May 2025.
Lonicerin (LON) at doses of 5 and 10 mg/kg reduced sleep latency and increased sleep duration in mice, with combined LON and diazepam showing maximal effects. Computational docking showed LON binds to GABAA receptor sites with a strong affinity (−8.1 kcal/mol), suggesting potential as an insomnia treatment. ABSTRACT Background: Lonicerin (LON) has been
Tanzila Akter Eity, Md. Shimul Bhuia, Raihan Chowdhury, Salehin Sheikh, Siddique Akber Ansari, Nowreen Tabassum Ahammed, Hossam Kamli, Muhammad Torequl Islam   +7 more
wiley   +1 more source

Long‐term in vivo performance of silicone membrane lungs coated with novel methacryloyloxyethyl phosphorylcholine polymers: A pilot study

Artificial Organs, Volume 49, Issue 5, Page 842-851, May 2025.
This pilot study demonstrates the long‐term durability and reduced thrombogenicity of a novel MPC‐coated silicone membrane lung, highlighting its potential for extended use in extracorporeal respiratory support. Abstract Background This study was designed to evaluate the long‐term durability, oxygenation, and pressure loss of newly developed ...
Masaki Anraku, Ryo Yokoi, Shintaro Hara, Yuya Nobori, Keita Nakao, Kento Fukumoto, Toshiya Ono, Kazuaki Sato, Fumikazu Watanabe, Takashi Isoyama, Hiroaki Oshiyama, Minoru Ono, Jun Nakajima, Madoka Takai   +13 more
wiley   +1 more source

Ventricular arrhythmogenic remodelling in diet‐induced metabolic syndrome driven by right‐to‐left regional differences in action potential duration and dominant frequency gradients

The Journal of Physiology, Volume 603, Issue 10, Page 2979-3000, 15 May 2025.
Abstract figure legend. Ventricular arrhythmogenic remodelling in diet‐induced metabolic syndrome (MetS) driven by right‐to‐left regional differences in action potential duration and dominant frequency gradients. An experimental model of diet‐induced MetS in rabbits (1) resulted in pathological remodelling in vivo, which was characterized by both ...
Óscar J. Arias‐Mutis, Conrado J. Calvo, Alexandra Bizy, Johan E. Ortiz‐Guzmán, Luis Such‐Miquel, Luis Such, Antonio Alberola, Jichao Zhao, Francisco J. Chorro, Manuel Zarzoso   +9 more
wiley   +1 more source