Results 161 to 170 of about 6,220 (214)

[Pharmacogenetic study of thiopurine S-methyltransferase (TPMT) and thiopurine toxicity].

Revista espanola de enfermedades digestivas, 2003
H, Corominas, C, Díaz, G, Vázquez, M, Baiget   +3 more
openaire   +1 more source

The role of pharmacogenetics in the therapy regimen of acute lymphoblastic leukemia in children: recent discoveries and future perspectives. [PDF]

Pharmacol Rep
Szoszkiewicz A, Światłowska A, Derwich K, Jamsheer A, Rubiś B, Bienert A.   +5 more
europepmc   +1 more source

An Ambiguous NUDT15 Signal in a Child with B-cell Acute Lymphoblastic Leukemia. [PDF]

Clin Chem
Sterner RM, Sherani F, DiGuardo MA, Greipp PT, Moyer AM.   +4 more
europepmc   +1 more source

Bone Marrow Aplasia and Neutropenic Fever Following Azathioprine Dose Escalation in a TPMT-Deficient Patient with Crohn's Disease and Psoriatic Arthritis-A CARE-Compliant Case. [PDF]

Clin Pract
Wroński K, Holecki MT, Boguszewska N, Skrzypczak-Zielińska M, Chudek JT.   +4 more
europepmc   +1 more source

Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency. [PDF]

Br J Clin Pharmacol
Wu AS, Mozessohn L, Kim RB, Zipursky JS.
europepmc   +1 more source

Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. [PDF]

Front Pharmacol
Kassa E, Birhan M, Ayalew M, Gelaw A, Gidey AM, Tilahun Worku D, Mekonen A, Teklehaimanot E, Asnakew A, Amare A, Berhane Tessemma N.   +10 more
europepmc   +1 more source

Examination of the TPMT and NUDT15*3 Variants to Predict the Response to Thiopurines in an Italian Cohort of Patients with Inflammatory Bowel Disease. [PDF]

Int J Mol Sci
Tavano F, Palmieri O, Latiano M, Gioffreda D, Latiano T, Guerra M, Martino G, Valvano MR, Bossa F, Perri F, Latiano A.   +10 more
europepmc   +1 more source

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Purine substrates for human thiopurine methyltransferase

Biochemical Pharmacology, 1994
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG). A genetic polymorphism regulating TPMT activity in human tissue is an important factor responsible for individual differences in the toxicity and therapeutic efficacy of these drugs.
M, Deininger, C L, Szumlanski, D M, Otterness, J, Van Loon, W, Ferber, R M, Weinshilboum   +5 more
openaire   +4 more sources

METHYLATION PHARMACOGENETICS: Catechol O-Methyltransferase, Thiopurine Methyltransferase, and Histamine N-Methyltransferase

Annual Review of Pharmacology and Toxicology, 1999
▪ Abstract  Methyl conjugation is an important pathway in the biotransformation of many exogenous and endogenous compounds. Pharmacogenetic studies of methyltransferase enzymes have resulted in the identification and characterization of functionally important common genetic polymorphisms for catechol O-methyltransferase, thiopurine methyltransferase ...
R M, Weinshilboum, D M, Otterness, C L, Szumlanski   +2 more
openaire   +4 more sources