Results 141 to 150 of about 206,003 (304)

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux   +7 more
wiley   +1 more source

Inactivation of thioredoxin by sulfite ions

open access: yes, 1990
Oxidized thioredoxin undergoes sulfitolysis of its single disulfide bond at low concentrations of sulfite ions and protein and in the absence of denaturing agents. The reaction, which has an optimum at pH 8, was studied using [35S]sulfite and E.
Häberlein, Ingo   +5 more
core   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson   +6 more
wiley   +1 more source

Chloroplast thioredoxin systems: prospects for improving photosynthesis

open access: yes, 2017
Thioredoxins (TRXs) are protein oxidoreductases that control the structure and function of cellular proteins by cleavage of a disulphide bond between the side chains of two cysteine residues.
Jouni Toivola   +3 more
core   +1 more source

Mitochondrial physiology in cardiac muscle of deer mice native to high altitude

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude deer mice exhibited evolved changes in mitochondrial energy metabolism and reactive oxygen species (ROS) management that may support cardiac performance under cold hypoxic conditions. High‐altitude mice had increased activity of lactate dehydrogenase (LDH) in the heart, probably enhancing the capacity for lactate ...
Ranim Saleem   +3 more
wiley   +1 more source

Thioredoxin/thioredoxin reductase system involvement in cerebellar granule cell apoptosis

open access: yes, 2014
The involvement of thioredoxin/thioredoxin reductase system has been investigated in cerebellar granule cells (CGCs), a cellular system in which neurons are induced in apoptosis by the physiological stimulus of lowering extracellular potassium ...
CASALINO, Elisabetta   +3 more
core   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

open access: yesQuantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang   +5 more
wiley   +1 more source

Strain‐Specific Biotransformation of Grape Marc by Lactic Acid Bacteria: Genomic Validation and Gut Microbiota Modulation

open access: yesFood Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Grape marc (GM) is a polyphenol‐rich winery byproduct that remains underutilized due to its complex fiber matrix, which limits the bioaccessibility of bound phenolics. While lactic acid fermentation (LAF) can enhance the release of these compounds, the strain‐specific metabolic fate of GM phenolics during digestion and colonic fermentation ...
Ziyao Liu   +4 more
wiley   +1 more source

Curcumin Attenuates Aroclor 1254‐Induced Oxidative, Genotoxic, and Apoptotic Alterations in HepG2 Cells

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
In HepG2 cells, Aroclor 1254 induced oxidative stress, DNA damage, apoptosis, and mutagenicity; co‐treatment with curcumin restored antioxidant defenses (GSH/thiols; SOD, CAT, GPx, GR, TrxR), reduced ROS and comet/8‐OHdG readouts, and attenuated caspase activation, demonstrating curcumin's hepatoprotective and genoprotective modulation of PCB toxicity.
Pınar Erkekoğlu   +3 more
wiley   +1 more source

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