Results 11 to 20 of about 206,003 (304)

A Rare Case of Coexisting Mutation in Desmin and Thioredoxin Reductase 2 Genes Causing Dilated Cardiomyopathy [PDF]

, 2023
Desmin (DES) maintains the overall structure of cardiomyocytes and cytoskeletal organization within striated muscle cells. Mitochondrial thioredoxin reductase 2 (TXNRD-2) is essential for mitochondrial oxygen radical scavenging.
Khatun, Nazima, Salciccioli, Louis, Zaveri, Sahil, John, Sabu   +3 more
core   +1 more source

Assessment of salivary thioredoxin levels in oral lichen planus and oral squamous cell carcinoma

Clinical and Experimental Dental Research, 2021
Objective Oral lichen planus (OLP) is a chronic mucocutaneous inflammatory disease, which is considered as a potentially malignant condition and could transformed into oral squamous cell carcinoma (OSCC).
Maryam Amirchaghmaghi, Roya Mahfoozi, Zohreh Dalirsani, Leila Vazifeh Mostaan, Seyed Isaac Hashemy, Mohammad Taghi Shakeri   +5 more
doaj   +1 more source

Thioredoxin and thioredoxin binding protein 2 in the liver [PDF]

IUBMB Life, 2008
AbstractThioredoxin (TRX) is a 12‐kDa protein with redox‐active dithiol in the active site ‐Cys‐Gly‐Pro‐Cys‐ and constitutes a major thiol reducing system. TRX protects cells from stress‐induced damage through antioxidative, antiapoptotic, and anti‐inflammatory effect.
Hiroaki, Okuyama, Aoi, Son, Md Kaimul, Ahsan, Hiroshi, Masutani, Hajime, Nakamura, Junji, Yodoi   +5 more
openaire   +2 more sources

Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation. [PDF]

PLoS ONE, 2013
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by acute enhancement of airway neutrophilic inflammation under oxidative stress and can be involved in emphysema progression. However, pharmacotherapy against the
Naoya Tanabe, Yuma Hoshino, Satoshi Marumo, Hirofumi Kiyokawa, Susumu Sato, Daisuke Kinose, Kazuko Uno, Shigeo Muro, Toyohiro Hirai, Junji Yodoi, Michiaki Mishima   +10 more
doaj   +1 more source

The role of thioredoxin reductases in brain development [PDF]

, 2008
The thioredoxin-dependent system is an essential regulator of cellular redox balance. Since oxidative stress has been linked with neurodegenerative disease, we studied the roles of thioredoxin reductases in brain using mice with nervous system (NS ...
Jonna Soerensen, Schmidt, Jörg, Soerensen, Jonna, Markus Brielmeier, Schweizer, Ulrich, Schmahl, W., Schweizer, U., Jakupoglu, Cemile, Brielmeier, Markus, Heike Beck, Schmahl, Wolfgang W., Marcus Conrad, Conrad, M., Jörg Schmidt, Brielmeier, M., Förster, Heidi, Conrad, Marcus, Förster, H., Beck, H., Wolfgang Schmahl, Beck, Heike, Jakupoglu, C., Cemile Jakupoglu, Soerensen, J., Heidi Förster, Ulrich Schweizer, Schmidt, J.   +26 more
core   +1 more source

Thioredoxin, produced by stromal cells retrieved from the lymph node microenvironment, rescues chronic lymphocytic leukemia cells from apoptosis in vitro

Haematologica, 2007
Background and Objectives The redox-regulatory protein thioredoxin has several functions including transcriptional regulation, and antioxidant, cytokine, and chemokine activities.
Eva Bäckman, Ann-Charlotte Bergh, Irena Lagerdahl, Björn Rydberg, Christer Sundström, Gerard Tobin, Richard Rosenquist, Mats Linderholm, Anders Rosén   +8 more
doaj   +1 more source

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. [PDF]

, 2009
The malarial parasite Plasmodium falciparum possesses a functional thioredoxin and glutathione system comprising the dithiol-containing redox proteins thioredoxin (Trx) and glutaredoxin (Grx), as well as plasmoredoxin (Plrx), which is exclusively found ...
Sturm, Nicole, Becker Katja, Koncarevic, Sasa, Forchhammer, Karl, Mailu, Boniface M., Rahlfs, Stefan, Katja Becker, Deponte, Marcel, Koncarevic Sasa, Becker, Katja, Sturm Nicole, Mailu Boniface M., Marcel Deponte, Deponte Marcel, Jortzik, Esther, Stefan Rahlfs, Jortzik Esther, Esther Jortzik, Karl Forchhammer, Nicole Sturm, Forchhammer Karl, Boniface M Mailu, Sasa Koncarevic, Rahlfs Stefan   +23 more
core   +1 more source

Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma

Journal of Hematology & Oncology, 2018
Background Although current chemotherapy using bortezomib (Velcade) against multiple myeloma in adults has achieved significant responses and even remission, a majority of patients will develop acquired resistance to bortezomib.
Zhihong Zheng, Shengjun Fan, Jing Zheng, Wei Huang, Cristina Gasparetto, Nelson J. Chao, Jianda Hu, Yubin Kang   +7 more
doaj   +1 more source

Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease. [PDF]

PLoS ONE, 2014
Understanding how pathogenic fungi adapt to host plant cells is of major concern to securing global food production. The hemibiotrophic rice blast fungus Magnaporthe oryzae, cause of the most serious disease of cultivated rice, colonizes leaf cells ...
Jessie Fernandez, Richard A Wilson
doaj   +1 more source

Identification of human thioredoxin as a novel IFN-gamma-induced factor: Mechanism of induction and its role in cytokine production

BMC Immunology, 2008
Background IFN-γ is a multifunctional peptide with a potent immune defense function which is also known as a prototypic Th1 cytokine. While screening for genes differentially expressed by Th1 and Th2 cytokines, human thioredoxin was identified as a novel
Kang Myoung-Wha, Jang Ji-Young, Choi Ja-Young, Oh Jiyoung, Kim Seol-Hee, Lee Choong-Eun   +5 more
doaj   +1 more source