Results 11 to 20 of about 194,628 (260)
Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation. [PDF]
PLoS ONE, 2013 BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by acute enhancement of airway neutrophilic inflammation under oxidative stress and can be involved in emphysema progression. However, pharmacotherapy against the
Naoya Tanabe +10 more
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Redox Regulation by Thioredoxin and Thioredoxin‐Binding Proteins [PDF]
IUBMB Life, 2001 AbstractRecent works have shown the importance of reduction/oxidation (redox) regulation in various biological phenomena. Thioredoxin is a 12‐kDa protein with redox‐active dithiol in the active site ‐Cys‐Gly‐Pro‐Cys‐ and constitutes a major thiol reducing system, the thioredoxin system.
A, Nishiyama +4 more
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Journal of Hematology & Oncology, 2018 Background Although current chemotherapy using bortezomib (Velcade) against multiple myeloma in adults has achieved significant responses and even remission, a majority of patients will develop acquired resistance to bortezomib.
Zhihong Zheng +7 more
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Thioredoxin and thioredoxin binding protein 2 in the liver [PDF]
IUBMB Life, 2008 AbstractThioredoxin (TRX) is a 12‐kDa protein with redox‐active dithiol in the active site ‐Cys‐Gly‐Pro‐Cys‐ and constitutes a major thiol reducing system. TRX protects cells from stress‐induced damage through antioxidative, antiapoptotic, and anti‐inflammatory effect.
Hiroaki, Okuyama +5 more
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BMC Immunology, 2008 Background IFN-γ is a multifunctional peptide with a potent immune defense function which is also known as a prototypic Th1 cytokine. While screening for genes differentially expressed by Th1 and Th2 cytokines, human thioredoxin was identified as a novel
Kang Myoung-Wha +5 more
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Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease. [PDF]
PLoS ONE, 2014 Understanding how pathogenic fungi adapt to host plant cells is of major concern to securing global food production. The hemibiotrophic rice blast fungus Magnaporthe oryzae, cause of the most serious disease of cultivated rice, colonizes leaf cells ...
Jessie Fernandez, Richard A Wilson
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Antioxidants, 2023 In silico approaches were employed to examine the characteristics of interactions between human mitochondrial thioredoxin 2 (HsTrx2) and its 38 previously identified mitochondrial protein ligands.
Charalampos Ntallis +4 more
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Kinetic analysis of the interactions between plant thioredoxin and target proteins
Frontiers in Plant Science, 2013 Thioredoxin is a critical protein that mediates the transfer of reducing equivalents in vivo and regulates redox sensitive enzymes in several cases. In addition, thioredoxin provides reducing equivalents to oxidoreductases such as peroxiredoxin.
Toru eHisabori, Satoshi eHara
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Crystal structure of the human thioredoxin reductase–thioredoxin complex [PDF]
Nature Communications, 2011 Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting drug target. Here we present the first crystal structures of human TrxR1 in complex with its substrate thioredoxin (Trx).
Fritz-Wolf, K. +4 more
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A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation
Бюллетень сибирской медицины, 2018 Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management.
E. V. Shakhristova +7 more
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