Results 41 to 50 of about 206,003 (304)

Autonomous Non Antioxidant Roles for Fasciola hepatica Secreted Thioredoxin-1 and Peroxiredoxin-1

Frontiers in Cellular and Infection Microbiology, 2021
Trematode parasites of the genus Fasciola are the cause of liver fluke disease (fasciolosis) in humans and their livestock. Infection of the host involves invasion through the intestinal wall followed by migration in the liver that results in extensive ...
Amber Dorey, Krystyna Cwiklinski, James Rooney, Carolina De Marco Verissimo, Jesús López Corrales, Heather Jewhurst, Barbara Fazekas, Nichola Eliza Davies Calvani, Siobhán Hamon, Siobhán Gaughan, John P. Dalton, Richard Lalor   +11 more
doaj   +1 more source

Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Redox Biology, 2016
Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea.
Ruixia Dong, Dongxu Wang, Xiaoxiao Wang, Ke Zhang, Pingping Chen, Chung S. Yang, Jinsong Zhang   +6 more
doaj   +1 more source

A Redox-Sensitive Cysteine Is Required for PIN1At Function

Frontiers in Plant Science, 2021
Parvulins are ubiquitous peptidyl-prolyl isomerases (PPIases) required for protein folding and regulation. Among parvulin members, Arabidopsis PIN1At, human PIN1, and yeast ESS1 share a conserved cysteine residue but differ by the presence of an N ...
Benjamin Selles, Tiphaine Dhalleine, Alexis Boutilliat, Nicolas Rouhier, Jérémy Couturier, Jérémy Couturier   +5 more
doaj   +1 more source

Chaperone properties of Escherichia coli thioredoxin and thioredoxin reductase [PDF]

Biochemical Journal, 2003
Thioredoxin, thioredoxin reductase and NADPH form the thioredoxin system and are the major cellular protein disulphide reductase. We report here that Escherichia coli thioredoxin and thioredoxin reductase interact with unfolded and denatured proteins, in a manner similar to that of molecular chaperones that are involved in protein folding and protein ...
Renée, Kern, Abderrahim, Malki, Arne, Holmgren, Gilbert, Richarme   +3 more
openaire   +2 more sources

The Antioxidant System of the Respiratory Tract. The Intracellular Antioxidant Protection in the Respiratory Tract (Part 4)

Zdorovʹe Rebenka, 2016
In the literature review, the current data about the thioredoxin system in the functioning of the intracellular antioxidant protection in the respiratory tract are outlined. The details of thioredoxin-dependent oxidation reaction are described.
A.E. Abaturov, A.P. Volosovets, T.P. Borysova   +2 more
doaj   +1 more source

Giardia lamblia: missing evidence for a canonical thioredoxin system [PDF]

, 2017
The microaerophilic protozoan parasite Giardia lamblia occurs globally and causes dysentery in humans and animals. Since it is very sensitive to oxygen and reactive oxygen species, G.
Müller, Norbert, David Leitsch, Leitsch, David, Norbert Müller, Rout, Samuel, Adrian Hehl, Lundström-Stadelmann, Britta, Britta Lundström-Stadelmann, Vreni Balmer, Hehl, Adrian, Samuel Rout, Balmer, Vreni   +11 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Insulin-like growth factor-I (IGF-I) and thioredoxin are differentially expressed along the reproductive tract of the ewe during the oestrous cycle and after ovariectomy

Acta Veterinaria Scandinavica, 2006
Insulin-like growth factor-I (IGF-I) and thioredoxin are regulated by gonadal steroids in the female reproductive tract of many species. Oestradiol regulates IGF-I and thioredoxin mRNA levels in the reproductive tract of prepubertal lambs.
Eriksson Håkan, Meikle Ana, van Lier Elize, Sahlin Lena   +3 more
doaj   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation.

PLoS ONE, 2016
Thioredoxin (Trx) is an oxidoreductase with important physiological function. Imbalances in the NADPH/thioredoxin reductase/thioredoxin system are associated with a number of pathologies, particularly cancer, and a number of clinical trials for ...
Clive Metcalfe, Anjana Ramasubramoni, Giordano Pula, Matthew T Harper, Stuart J Mundell, Carmen H Coxon   +5 more
doaj   +1 more source