Results 21 to 30 of about 198,692 (251)

Thioredoxin-1 protects against neutrophilic inflammation and emphysema progression in a mouse model of chronic obstructive pulmonary disease exacerbation. [PDF]

PLoS ONE, 2013
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are characterized by acute enhancement of airway neutrophilic inflammation under oxidative stress and can be involved in emphysema progression. However, pharmacotherapy against the
Naoya Tanabe, Yuma Hoshino, Satoshi Marumo, Hirofumi Kiyokawa, Susumu Sato, Daisuke Kinose, Kazuko Uno, Shigeo Muro, Toyohiro Hirai, Junji Yodoi, Michiaki Mishima   +10 more
doaj   +1 more source

Thioredoxin and thioredoxin binding protein 2 in the liver [PDF]

IUBMB Life, 2008
AbstractThioredoxin (TRX) is a 12‐kDa protein with redox‐active dithiol in the active site ‐Cys‐Gly‐Pro‐Cys‐ and constitutes a major thiol reducing system. TRX protects cells from stress‐induced damage through antioxidative, antiapoptotic, and anti‐inflammatory effect.
Hiroaki, Okuyama, Aoi, Son, Md Kaimul, Ahsan, Hiroshi, Masutani, Hajime, Nakamura, Junji, Yodoi   +5 more
openaire   +2 more sources

Distinct or Overlapping Areas of Mitochondrial Thioredoxin 2 May Be Used for Its Covalent and Strong Non-Covalent Interactions with Protein Ligands

Antioxidants, 2023
In silico approaches were employed to examine the characteristics of interactions between human mitochondrial thioredoxin 2 (HsTrx2) and its 38 previously identified mitochondrial protein ligands.
Charalampos Ntallis, Haralampos Tzoupis, Theodore Tselios, Christos T. Chasapis, Alexios Vlamis-Gardikas   +4 more
doaj   +1 more source

Identification of human thioredoxin as a novel IFN-gamma-induced factor: Mechanism of induction and its role in cytokine production

BMC Immunology, 2008
Background IFN-γ is a multifunctional peptide with a potent immune defense function which is also known as a prototypic Th1 cytokine. While screening for genes differentially expressed by Th1 and Th2 cytokines, human thioredoxin was identified as a novel
Kang Myoung-Wha, Jang Ji-Young, Choi Ja-Young, Oh Jiyoung, Kim Seol-Hee, Lee Choong-Eun   +5 more
doaj   +1 more source

Characterizing roles for the glutathione reductase, thioredoxin reductase and thioredoxin peroxidase-encoding genes of Magnaporthe oryzae during rice blast disease. [PDF]

PLoS ONE, 2014
Understanding how pathogenic fungi adapt to host plant cells is of major concern to securing global food production. The hemibiotrophic rice blast fungus Magnaporthe oryzae, cause of the most serious disease of cultivated rice, colonizes leaf cells ...
Jessie Fernandez, Richard A Wilson
doaj   +1 more source

Crystal structure of the human thioredoxin reductase–thioredoxin complex [PDF]

Nature Communications, 2011
Thioredoxin reductase 1 (TrxR1) is a homodimeric flavoprotein crucially involved in the regulation of cellular redox homeostasis, growth, and differentiation. Its importance in various diseases makes TrxR1 a highly interesting drug target. Here we present the first crystal structures of human TrxR1 in complex with its substrate thioredoxin (Trx).
Fritz-Wolf, Karin, Kehr, Sebastian, Stumpf, Michaela, Rahlfs, Stefan, Becker, Katja   +4 more
openaire   +3 more sources

Kinetic analysis of the interactions between plant thioredoxin and target proteins

Frontiers in Plant Science, 2013
Thioredoxin is a critical protein that mediates the transfer of reducing equivalents in vivo and regulates redox sensitive enzymes in several cases. In addition, thioredoxin provides reducing equivalents to oxidoreductases such as peroxiredoxin.
Toru eHisabori, Satoshi eHara
doaj   +1 more source

A multi-centre study on the role of the thioredoxin system in breast cancer cell proliferation

Бюллетень сибирской медицины, 2018
Redox proteins (thioredoxin, glutaredoxin) are key macromolecules capable of modulating intracellular processes. This determines research choices in the field of redox-dependent cell proliferation management.
E. V. Shakhristova, E. A. Stepovaya, O. L. Nosareva, L. S. Litvinova, D. A. Skuratovskaya, E. V. Rudikov, A. A. Sadykova, V. V. Novitsky   +7 more
doaj   +1 more source

Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis

Antioxidants, 2022
Peritoneal dialysis (PD) is an effective method of renal replacement therapy, providing a high level of patient autonomy. Nevertheless, the long-term use of PD is limited due to deleterious effects of PD fluids to the structure and function of the ...
Tina Oberacker, Peter Fritz, Moritz Schanz, Mark Dominik Alscher, Markus Ketteler, Severin Schricker   +5 more
doaj   +1 more source

Evidence that protein thiols are not primary targets of intracellular reactive oxygen species in growing Escherichia coli

Frontiers in Microbiology, 2023
The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be.
Stefanie S. Eben, James A. Imlay
doaj   +1 more source