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Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth. [PDF]
Cancer Biol TherJohnson SS +12 more
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Measurement of Thioredoxin and Thioredoxin Reductase
Current Protocols in Toxicology, 2005AbstractThe thioredoxin system is ubiquitous, providing reducing equivalents to essential biosynthetic enzymes like ribonucleotide reductase. It is essential for cellular redox regulation, control of oxidative stress, and protection against oxidative damage.
E S, Arnér, A, Holmgren
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Thioredoxins and thioredoxin reductase in chloroplasts: A review
Gene, 2019The chloroplastic thioredoxins (Trxs), a family of thiol-disulphide oxidoreductases, are reduced by either ferredoxin (Fd)-dependent Trx reductase (FTR) or reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent Trx reductase (NTR). Two Trx systems are present in chloroplasts including Trxs, Trx-like proteins, and reductase FTR and NTRC ...
Zhenhui Kang, Tong Qin, Zhiping Zhao
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Proteins: Structure, Function, and Bioinformatics, 2008
AbstractThioredoxin glutathione reductase (TGR) is a key flavoenzyme expressed by schistosomes that bridges two detoxification pathways crucial for the parasite survival in the host's organism. In this article we report the crystal structure (at 2.2 Å resolution) of TGR from Schistosoma mansoni (SmTGR), deleted in the last two residues.
ANGELUCCI, Francesco +5 more
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AbstractThioredoxin glutathione reductase (TGR) is a key flavoenzyme expressed by schistosomes that bridges two detoxification pathways crucial for the parasite survival in the host's organism. In this article we report the crystal structure (at 2.2 Å resolution) of TGR from Schistosoma mansoni (SmTGR), deleted in the last two residues.
ANGELUCCI, Francesco +5 more
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Archives of Dermatology, 1987
• Membrane-associated thioredoxin reductase (TR) has been discovered to reduce free radicals at the surface of the skin. An accurate bioassay for this enzyme has been developed by using a spin-labeled quaternary ammonium salt as a free radical substrate. Enzyme activity has been correlated with the surface area, and units of specific activity have been
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• Membrane-associated thioredoxin reductase (TR) has been discovered to reduce free radicals at the surface of the skin. An accurate bioassay for this enzyme has been developed by using a spin-labeled quaternary ammonium salt as a free radical substrate. Enzyme activity has been correlated with the surface area, and units of specific activity have been
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Preparation and assay of mammalian thioredoxin and thioredoxin reductase
1999Publisher Summary This chapter describes the preparation and assay of mammalian thioredoxin and thioredoxin reductase (TrxR). The amino acid sequences of mammalian TrxR revealed a strikingly high homology to glutathione reductase. 14,19 The conserved features of all the structural components of glutathione reductase are preserved in mammalian TrxR ...
E S, Arnér, L, Zhong, A, Holmgren
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Kinetics of electron transfer from thioredoxin reductase to thioredoxin
Biochemistry, 1991The reduction of Escherichia coli thioredoxin by thioredoxin reductase was studied by stopped-flow spectrophotometry. The reaction showed no dependence on thioredoxin concentration, indicating that complex formation was rapid and occurred during the dead time of the instrument.
J A, Navarro +5 more
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Cytosolic, Mitochondrial Thioredoxins and Thioredoxin Reductases in Arabidopsis Thaliana
Photosynthesis Research, 2004Thioredoxins, by reducing disulfide bridges are one of the main participants that regulate cellular redox balance. In plants, the thioredoxin system is particularly complex. The most well-known thioredoxins are the chloroplastic ones, that participate in the regulation of enzymatic activities during the transition between light and dark phases.
Bréhélin, Claire +4 more
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