Results 141 to 150 of about 6,985 (261)

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Systematic determination of disulfide bond reduction potentials reveals a nonequilibrium redox hierarchy in cyanobacteria. [PDF]

Proc Natl Acad Sci U S A
Tanaka K, Kondo A, Hasunuma T.
europepmc   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

An Update on Oxidative Stress and Redoxins in Pancreatitis. [PDF]

Cell Mol Gastroenterol Hepatol
Assi M.
europepmc   +1 more source

Editorial: Chloroplast redox state: new insights into stress responses and acclimation. [PDF]

Front Plant Sci, 2023
Zaffagnini M, Pilarska M, Niewiadomska E.   +2 more
europepmc   +1 more source

Why a Chloroplast Needs Its Own Genome Tethered to the Thylakoid Membrane—Co‐Location for Redox Regulation

BioEssays, Volume 48, Issue 8, August 2026.
A schematic outline of chloroplast DNA tethered to two stacked thylakoids that contain the components of photosynthetic electron transport. Green shapes represent proteins encoded in chloroplast DNA; brown shapes represent proteins encoded in the cell nucleus. ABSTRACT A chloroplast is a subcellular organelle of photosynthesis in plant and algal cells.
John F. Allen
wiley   +1 more source

Redox Modulation in Therapy of Cancer: Some Pros and Cons. [PDF]

Antioxidants (Basel)
Zorova LD, Semenovich DS, Zorov SD, Oleynikov IP, Kargapoltceva AS, Prutskikh DV, Abramicheva PA, Pevzner IB, Sukhikh GT, Zorov DB.   +9 more
europepmc   +1 more source

Overcoming Radiation Resistance: Ferroptosis Induction to Sensitize Solid Tumors to Radiation Therapy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Radiation therapy (RT) is a mainstay of treatment for a myriad of cancers, often utilized for tumors that are unable to be resected, as well as an adjunct to surgery and chemotherapy. Unfortunately, many cancers are resistant to RT‐induced damage and subsequent cell death.
Joseph Carmicheal, Caden M. Fritson, Alexandra Seas, Heidi Vieira, Surinder K. Batra   +4 more
wiley   +1 more source

Transcriptomic identification of potential antioxidative enzyme regulators of the gametophytic-to-embryogenic switch in barley microspores. [PDF]

Front Plant Sci
Nowicka A, Milec Z, Krzewska M, Kopeć P, Springer A, Dubas E, Żur I.   +6 more
europepmc   +1 more source

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source