Results 161 to 170 of about 8,012 (300)

Topological metrics as evolutionary and dynamical descriptors of conformational landscapes within protein families. [PDF]

PLoS Comput Biol
Ramesh N, Ozkan SB, Panagiotou E.
europepmc   +1 more source

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein citrullination, driven by peptidyl arginine deiminases (PAD2, PAD4), is linked to multiple diseases. Using a combinatorial peptide library and advanced mass spectrometry, we reveal distinct substrate selectivity profiles of PAD2 and PAD4. While PAD2 broadly citrullinates arginine‐containing peptides, PAD4 is highly sequence‐restricted, with ...
Adina Borbély, Arnold Steckel, Dávid Papp, Domonkos Pál, Katalin Uray, Viktória Goldschmidt Gőz, Gitta Schlosser   +6 more
wiley   +1 more source

Breaking self-incompatibility for diploid hybrid potato breeding: advances, mechanisms, and emerging technologies. [PDF]

Front Plant Sci
Wang Y, Lin T, Wang Z, Fan L, Wang Y, Jiao X, Wang W, Zong X, Chen J, Yin Y.   +9 more
europepmc   +1 more source

The role of thioredoxin proteins in Mycobacterium tuberculosis probed by proteome-wide target profiling. [PDF]

Biochem Biophys Rep, 2023
Sugandhi S, Rajmane V, Taunk K, Jadhav S, Nema V, Rapole S, Mande SC.   +6 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Atypical thioredoxin Patrx2 enhances alginate production in mucoid Pseudomonasaeruginosa. [PDF]

Redox Biol
Grandjean MM, Sturgis JN, Garcin EB, Ba M, Bornet O, Bordi C, Elantak L, Sebban-Kreuzer C.   +7 more
europepmc   +1 more source

Potential unrecognized redox-active atypical thioredoxins in eukaryote photosynthetic organisms

International audiencePhotosynthetic organisms have a high diversity of proteins belonging to the thioredoxin (TRX) superfamily. It comprises more than 150 proteins distributed in different families and classes, including in particular thioredoxins ...
Couturier, Jérémy, Donnay, Natacha, Favier, Frédérique, Didierjean, Claude, de Bont, Linda, Rouhier, Nicolas   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Identification and functional characterization of a novel thioredoxin MpTRX1 from Metschnikowia persimmonesis. [PDF]

Appl Microbiol Biotechnol
Kang CH, Lee JH, Lee YM, Lee YB, Kang Y, Ban Y, Haniffadli A, Rahmat E, Lim CO.   +8 more
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, Volume 13, Issue 31, 4 June 2026.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source