Results 181 to 190 of about 8,012 (300)

Santamarine Synergizes With Cisplatin via ROS/JNK Axis to Selectively Induce Apoptosis and DNA Damage in Oral Cancer Cells In Vitro

open access: yesDrug Development Research, Volume 87, Issue 4, June 2026.
ABSTRACT Santamarine (SAMA), a Michelia compressa‐derived sesquiterpene lactone, exhibits ROS‑mediated anticancer activity; however, its potential mechanisms and synergy with cisplatin in oral cancer have not been explored. This study investigated SAMA and cisplatin's combined effects and underlying ROS/MAPK mechanisms of action on oral cancer cells ...
Hsin‐I. Lu   +8 more
wiley   +1 more source

Multi‐Omics Analyses Elucidate the Venom Components of the Wasp Vespa mandarinia

open access: yesEcology and Evolution, Volume 16, Issue 6, June 2026.
The wasp Vespa mandarinia was widely reared in Yunnan province. The venom was responsible for their aggressive behavior. Tweety proteases, hyaluronidase, venom dipeptidyl peptidase 4, and phospholipase A1 and A2 isozyme were identified. In addition, organic heterocyclic compounds, organic acids, and derivatives were found.
Yuan‐Chong Shi   +4 more
wiley   +1 more source

TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD

open access: yesImmunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
This graphical abstract illustrates TCM syndrome differentiation‐guided targeted strategies against NLRP3 inflammasome‐mediated non‐alcoholic fatty liver disease (NAFLD). Metabolic dysfunction and gut‐liver axis dysregulation drive NAFLD progression, activating the NLRP3 inflammasome (comprising NLRP3, ASC, caspase‐1) to trigger cytokine release (IL‐1β,
Yanxia Zhang
wiley   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak   +9 more
wiley   +1 more source

Redox Modulation in Therapy of Cancer: Some Pros and Cons. [PDF]

open access: yesAntioxidants (Basel)
Zorova LD   +9 more
europepmc   +1 more source

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