Results 61 to 70 of about 31,059 (323)

Solution Structures of \u3cem\u3eMycobacterium tuberculosis\u3c/em\u3e Thioredoxin C and Models of Intact Thioredoxin System Suggest New Approaches to Inhibitor and Drug Design [PDF]

, 2013
Here, we report the NMR solution structures of Mycobacterium tuberculosis (M. tuberculosis) thioredoxin C in both oxidized and reduced states, with discussion of structural changes that occur in going between redox states.
Cai, Sheng, Neumann, Terrence S., Olson, Andrew Lawrence, Sem, Daniel S.   +3 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Major host transitions are modulated through transcriptome-wide reprogramming events inSchistocephalus solidus, a threespine stickleback parasite [PDF]

, 2016
Parasites with complex life cycles have developed numerous phenotypic strategies, closely associated with developmental events, to enable the exploitation of different ecological niches and facilitate transmission between hosts.
Adamo, Aly, Auld, Barber, Barber, Barber, Barber, Barrett, Beis, Benesh, Charles, Clarke, Conradt, Davidson, Hammerschmidt, Hammerschmidt, Hammerschmidt, Hopkins, Hopkins, Hopkins, Hopkins, Hébert, Hébert, Hébert, Koziol, Körting, Langmead, Law, Lee, Marr, Oshima, Pavey, Poulin, R Development Core Team, Robinson, Scharsack, Scharsack, Schjørring, Smyth, Smyth, Smyth, Smyth, Smyth, Threadgold, Tierney, Warnes, Wilbur, Williams   +47 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The paternal genome and the health of the assisted reproductive technology child

Asian Journal of Andrology, 2015
As a number of children born by assisted reproductive technology (ART) are increasing each year across the developed world, the health of such offspring is a matter of public concern.
Sheena EM Lewis, Kishlay Kumar
doaj   +1 more source

Comparison of Reduction Activity of three Rice (Oryza sativa) Thioredoxin Isoforms in Reaction with Insulin [PDF]

مجله بیوتکنولوژی کشاورزی, 2012
Thioredoxins (Trxs) are ubiquitous, low-molecular-mass proteins with two cysteins in their active site WC(G/P)PC which are involved in reversible reduction of disulfide bonds. Plants contain several forms of Trxs.
zahra popzan, Azar SHahpiri
doaj   +1 more source

Thioredoxin and thioredoxin binding protein 2 in the liver [PDF]

IUBMB Life, 2008
AbstractThioredoxin (TRX) is a 12‐kDa protein with redox‐active dithiol in the active site ‐Cys‐Gly‐Pro‐Cys‐ and constitutes a major thiol reducing system. TRX protects cells from stress‐induced damage through antioxidative, antiapoptotic, and anti‐inflammatory effect.
Hiroaki, Okuyama, Aoi, Son, Md Kaimul, Ahsan, Hiroshi, Masutani, Hajime, Nakamura, Junji, Yodoi   +5 more
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Functional Characterization of Two Thioredoxin Proteins of Toxoplasma gondii Using the CRISPR-Cas9 System

Frontiers in Veterinary Science, 2021
Toxoplasmosis caused by infection with Toxoplasma gondii is an important parasitic zoonosis with a worldwide distribution. In this study, we examined the functions of two thioredoxins (namely CTrp26 and CTrx1) of T. gondii tachyzoites by generation of HA
Zhi-Wei Zhang, Ting-Ting Li, Jin-Lei Wang, Qin-Li Liang, Hai-Sheng Zhang, Li-Xiu Sun, Xing-Quan Zhu, Xing-Quan Zhu, Xing-Quan Zhu   +8 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source