, 2015 The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype.
Davenport, Anthony P +8 more
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Treatment of Acute Diarrhoea: Past and Now [PDF]
, 2015 Context: Since ancient times diarrhoea has been a highly fatal disease and even today diarrhoea, the topic of this review, is a problem affecting millions of people around the world despite the efforts of governments and professionals from the medical ...
Caramia, Giuseppe +3 more
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Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney [PDF]
, 2016 Cardiovascular and renal pathologies are frequently associated with an activated renin-angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor hormone angiotensin II (Ang II). Angiotensin-converting-enzyme-2 (ACE2) has been
Antlanger, M. +16 more
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The Analgesic Activity of Bestatin as a Potent APN Inhibitor [PDF]
, 2010 Bestatin, a small molecular weight dipeptide, is a potent inhibitor of various aminopeptidases as well as LTA4 hydrolase. Various physiological functions of Bestatin have been identified, viz.: (1) an immunomodifier for enhancing the proliferation of ...
Jia, Mei-Rong, Wei, Tao, Xu, Wen-Fang
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Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation [PDF]
, 2000 BACKGROUND: The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization process in response to agonist stimulation.
Gastard, Myriam
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Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis [PDF]
, 2018 Alzheimer's disease, responsible for the vast majority of dementia cases in the elderly population, is caused by accumulation of toxic levels of amyloid β peptide (Aβ) in the brain.
Mohajeri, M., Wolfer, David
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Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure [PDF]
, 2007 Introduction The work described in this thesis looks particularly but not exclusively at two recently developed molecules which have dual enzyme inhibitor activity.
Seed, Alison
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Natural Products in Organic Synthesis [PDF]
, 1996 A resume of four lectures presented by the author during a one month visit to BIOTROP in 1995. The seminars were held at the University of Indonesia at Depok, the Technical Institute in Bandung, the Bogor Agricultural Institute and at ...
BURNELL, R. H. (ROBERT)
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Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate [PDF]
, 2010 Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role
Chua, Yee Jia +7 more
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The inactivation of enkephalins by brain tissue [PDF]
, 1985 Imperial Users ...
Pritchard, K., Pritchard, K.
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