Results 71 to 80 of about 2,737 (218)

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Journal of Diabetes Research, 2014
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia   +3 more
doaj   +1 more source

Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine α‐amidating monooxygenase (PAM) [PDF]

FEBS Letters, 2005
Peptidyglycine α‐amidating monooxygenase is a copper‐ and zinc‐dependent, bifunctional enzyme that catalyzes the cleavage of glycine‐extended peptides or N‐acylglycines to the corresponding amides and glyoxylate. This reaction is a key step in the biosynthesis of bioactive α‐amidated peptides and, perhaps, the primary fatty acids amides also.
McIntyre, Neil R., Lowe, Edward W., Chew, Geoffrey H., Owen, Terrence C., Merkler, David J.   +4 more
openaire   +2 more sources

Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy

Pharmacogenomics and Personalized Medicine, 2022
Huasheng Huang,* Xiwen Liao,* Guangzhi Zhu, Chuangye Han, Xiangkun Wang, Chengkun Yang, Xin Zhou, Tianyi Liang, Ketuan Huang, Tao Peng Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning ...
Huang H, Liao X, Zhu G, Han C, Wang X, Yang C, Zhou X, Liang T, Huang K, Peng T   +9 more
doaj  

Mapping small molecule binding data to structural domains. [PDF]

, 2012
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Kruger, Felix A, Overington, John P, Rostom, Raghd   +2 more
core   +3 more sources

Treatment of Acute Diarrhoea: Past and Now [PDF]

, 2015
Context: Since ancient times diarrhoea has been a highly fatal disease and even today diarrhoea, the topic of this review, is a problem affecting millions of people around the world despite the efforts of governments and professionals from the medical ...
Caramia, Giuseppe, Coman, MARIA MAGDALENA, Silvi, Stefania, Verdenelli, Maria Cristina   +3 more
core   +2 more sources

Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs

Journal of Veterinary Internal Medicine, Volume 39, Issue 1, January/February 2025.
Abstract Background The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood. Objective Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long‐term course of orally administered prednisolone.
Mathieu Victor Paulin, Dorsa Mehrabanpour, Suraj Unniappan, Elisabeth C. R. Snead   +3 more
wiley   +1 more source

Endothelin. [PDF]

, 2015
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype.
Davenport, Anthony P, Dhaun, Neeraj, Hyndman, Kelly A, Kohan, Donald E, Maguire, Janet J, Pollock, David M, Pollock, Jennifer S, Southan, Christopher, Webb, David J   +8 more
core   +3 more sources

Neuronal glutathione depletion elevates the Aβ42/Aβ40 ratio and tau aggregation in Alzheimer's disease mice

FEBS Letters, Volume 598, Issue 13, Page 1576-1590, July 2024.
This study aimed to elucidate the impact of glutathione depletion on aging and neurodegeneration in Alzheimer's pathology (amyloid and tau pathologies). We demonstrated that glutathione reduction, mediated by glutamate‐cysteine ligase catalytic subunit (GCLC) deficiency, elevated Aβ42/40 levels and facilitated tau polymerization through disulfide‐bond ...
Khairun Nisa Binti Hashim, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Ikuo Tooyama, Takaomi C. Saido, Shoko Hashimoto   +6 more
wiley   +1 more source

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. [PDF]

, 2016
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors.
Alexandrou, AJ, Brown, AR, Butt, RP, Castle, NA, Chapman, ML, Cox, PJ, Dib-Hajj, SD, Doyle, R, Estacion, M, Gutteridge, A, Hounshell, JA, Krafte, D, Lin, Z, Marron, BE, Mis, MA, Patel, MK, Payne, EC, Printzenhoff, D, Randall, A, Rivara, M, Stevens, EB, Storer, RI, Stupple, PA, Swain, NA, Turner, J, Waxman, SG, West, C, Wilbrey, A   +27 more
core   +1 more source

Exploring and comparing the anti‐obesity mechanisms of defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber based on multi‐omics technologies

Food Frontiers, Volume 5, Issue 2, Page 708-721, March 2024.
Defatted rice bran total dietary fiber, insoluble dietary fiber, and soluble dietary fiber have notable improvement effects on obese mice. However, their potential anti‐obesity mechanisms share similarities and differences, which contributes to the advancement of personalized dietary development in the future.
Bing Zheng, Xiaole Zhao, Tianxiang Ao, Jianhua Xie, Yi Chen, Yueyao Gui, Xingcai Gao, Xiaobo Hu, Qiang Yu   +8 more
wiley   +1 more source