Results 21 to 30 of about 9,384 (213)

Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

Microbiology Spectrum, 2022
Metal chelation is generally considered as a promising antifungal approach but its specific mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert broad-spectrum antifungal activity with potency comparable or superior to ...
Ximeng Duan, Zhiyu Xie, Liying Ma, Xueyang Jin, Ming Zhang, Yuliang Xu, Yue Liu, Hongxiang Lou, Wenqiang Chang   +8 more
doaj   +1 more source

Crystal structure of 4-hydroxy-3-methoxybenzaldehyde 4-methylthiosemicarbazone methanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title solvate, C15H15N3O2S·CH3OH, the thiosemicarbazone molecule is approximately planar; the maximum deviation from the mean plane is 0.4659 (14) Å and the dihedral angle between the aromatic rings is 9.83 (8)°.
Adriano Bof de Oliveira, Johannes Beck, Christian Landvogt, Bárbara Regina Santos Feitosa   +3 more
doaj   +1 more source

Search for conformation of thiosemicarbazone reagents and their complexes with metals by using Monte Carlo and docking simulation

Tạp chí Khoa học Đại học Huế: Khoa học Tự nhiên, 2020
In this study, the conformation of ML2 complexes of new thiosemicarbazone reagents with metal cations Cd2+, Ni2+, Cu2+, Hg2+, Pb2+, Mn2+, and Zn2+ is investigated.
Nguyen Minh Quang, Tran Xuan Mau, Pham Nu Ngoc Han, Pham Van Tat   +3 more
doaj   +1 more source

New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Molecules, 2021
Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity.
Ahmed Gaber, Moamen S. Refat, Arafa A.M. Belal, Ibrahim M. El-Deen, Nader Hassan, Rozan Zakaria, Majid Alhomrani, Abdulhakeem S. Alamri, Walaa F. Alsanie, Essa M. Saied   +9 more
doaj   +1 more source

Synthesis, Antiproliferative and Antimalarial Activities of Dinuclear Silver(I) Complexes with Triphenylphosphine and Thiosemicarbazones Ligands

Indonesian Journal of Chemistry, 2021
A series of six sulfur-bridged dinuclear silver(I) thiosemicarbazone complexes were synthesized through the reaction of silver(I) nitrate with 4-phenyl-3-thiosemicarbazone derivatives together with triphenylphosphine (PPh3) (in a 1:1:2 molar ratio ...
Nur Adila Fatin Mohd Khir, Mohd Ridzuan Mohd Abdul Razak, Fariza Juliana Nordin, Nur Rahimah Fitrah Mohd Sofyan, Nur Fadilah Rajab, Rozie Sarip   +5 more
doaj   +1 more source

A Tale of Two Mechanisms: The p53 Modulator COTI-2 Is a Zn Metallochaperone. [PDF]

Drug Dev Res
ABSTRACT Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. Tp53 mutations often induce conformational changes that inhibit activity; however, small‐molecule chaperones could theoretically restore conformation and activity. COTI‐2,
Şimşek İ, Shahbazi-Raz F, Krause MJ, Mohammadzadeh A, Kosar M, Xu P, Khan S, Tykhoniuk O, DaDalt A, Almasri D, Watanabe LK, Breault K, Hayward JJ, Pick FS, Ho RL, Rawson JM, Trant JF.   +16 more
europepmc   +2 more sources

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms [PDF]

, 2016
Background Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, namely di-2-pyridylketone 4,4 ...
Zhu-Ling Guo (3542162), Guo, Zhu-Ling, Kian Tan-Un (3542153), Tan-Un, Kian Cheng, Zaklina Kovacevic (1435045), Godfrey Chan (3542156), Kovacevic, Zaklina, Des R. Richardson, Zaklina Kovacevic, Zhu-Ling Guo, Kian Cheng Tan-Un, Des Richardson (3542159), Godfrey Chi-Fung Chan, Chan, Godfrey Chi-Fung, Danuta Kalinowski (3542150), Richardson, Des R, Danuta S. Kalinowski, Kalinowski, Danuta S   +17 more
core   +1 more source

Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

Ciência e Agrotecnologia, 2014
Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A.
Rojane de Oliveira Paiva, Lucimar Ferreira Kneipp, Carla Marins Goular, Mariana Almeida Albuquerque, Aurea Echevarria   +4 more
doaj   +1 more source

Comparative studies of two benzaldehyde thiosemicarbazone derivatives as corrosion inhibitors for mild steel in 1.0 M HCl

Results in Physics, 2018
Two benzaldehyde thiosemicarbazone derivatives namely 3-methoxy,4-hydroxyl-benzaldehyde thiosemicarbazone (MHBT) and 2-hydroxyl,3-methoxy-benzaldehyde thiosemicarbazone (HMBT) were synthesized and their inhibition behavior for mild steel in 1.0 M HCl ...
H.H. Zhang, Y. Chen, Z. Zhang
doaj   +1 more source

The phosphinoboration of thiosemicarbazones

Canadian Journal of Chemistry, 2023
This study reports on the exploration of the phosphinoboration reaction with several thiosemicarbazones (R5R4NC(S)NR3N=CR1R2). Reactions between either Ph2PBpin (pin = 1,2-O2C2Me4) or Ph2PBcat (cat = 1,2-O2C6H4) with thiosemicarbazones containing a terminal primary or secondary amine afforded boron-containing heterocyclic 1,3,4-thiadiazoline products ...
Samuel R. Baird, Christopher M. Vogels, Stephen J. Geier, Lara K. Watanabe, Justin F. Binder, Charles L. B. Macdonald, Stephen A. Westcott   +6 more
openaire   +2 more sources