Results 21 to 30 of about 7,932 (222)

X-ray Diffraction Study of Fluorine-Functionalized Thiosemicarbazones and Cyclometallated Compounds

Chemistry Proceedings, 2022
In this work, an X-ray diffraction study of fluorine-functionalized thiosemicarbazone ligands and their corresponding cyclometallated compounds is discussed.
Marcos Rúa-Sueiro, Paula Munín-Cruz, Juan M. Ortigueira, José M. Vila   +3 more
doaj   +1 more source

Novel Thiosemicarbazone Derivatives from Furan-2-Carbaldehyde: Synthesis, Characterization, Crystal Structures, and Antibacterial, Antifungal, Antioxidant, and Antitumor Activities

Journal of Chemistry, 2023
Ten new thiosemicarbazone derivatives, furan-2-carbaldehyde thiosemicarbazone (1), 3-methyl-furan-2-carbaldehyde thiosemicarbazone (2), 5-hydroxymethyl-furan-2-carbaldehyde thiosemicarbazone (3), 5-trifluoromethyl-furan-2-carbaldehyde thiosemicarbazone ...
Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Maik Icker, Harald Krautscheid, Lothar Beyer, Carmen Tamariz-Angeles, Percy Olivera-Gonzales   +8 more
doaj   +1 more source

Antimicrobial, antibiofilm, docking, DFT and molecular dynamics studies on click-derived isatin-thiosemicarbazone-1,2,3-triazoles

, 2023
In an effort to develop new antimicrobial and antibiofilm agents, we have designed and synthesized a novel class of isatin-thiosemicarbazone-1,2,3-triazoles through the CuAAC approach.
Mohd Murtaza (13230741), Aman Kumar (762642), Kashmiri Lal (2442955), Sundeep Jaglan (2569399), Madhur Babu Singh (11988250), Yajat Rohila (16964447), Prashant Singh (729773), Kamlesh Kumari (7215059)   +7 more
core   +1 more source

Synthesis and Characterization of Novel Thiazolidinones and Thioxothiazolidinones Derived from Substituted Indole

Molbank, 2021
Based on recent discoveries concerning the numerous biological properties of thiazolidinones and thiosemicarbazones, new N-substituted heterocyclic derivatives have been designed by combining the indole ring with thioxothiazolidinone, thiazolidinone or ...
Nawel Rekiba, Abdelmadjid Benmohammed, Sofiane Khanoussi, Ayada Djafri, Jérôme Thibonnet   +4 more
doaj   +1 more source

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives. [PDF]

Biotechnol Appl Biochem
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Gezegen H, Özbek O, Topal M, Şahin H, Koçyiğit ÜM.   +4 more
europepmc   +2 more sources

An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study

Journal of Analytical Science and Technology, 2020
Background Bromophenol-thiosemicarbazone hybrid was a novel synthetic brominated anticancer compound with two bromine atoms. Bromophenol-thiosemicarbazone hybrid showed considerable selective inhibitory activity against PARP1 (IC50 = 29.5 nmol/L).
Xiuxue Li, Lijun Wang, Xiaoling Jia, Chuanlong Guo, Chao Li, Jiajia Zhang, Dayong Shi   +6 more
doaj   +1 more source

Half-Sandwich Arene Ruthenium(II) Thiosemicarbazone Complexes: Evaluation of Anticancer Effect on Primary and Metastatic Ovarian Cancer Cell Lines

Frontiers in Pharmacology, 2022
In this study, we describe the synthesis, characterization and antiproliferative activity of three organo-ruthenium(II) half-sandwich complexes [RuCl(η6-p-cym)(N,S-L)]Cl (I, II, and III).
Seminay Guler, Seminay Guler, Hulya Ayar Kayali, Hulya Ayar Kayali, Hulya Ayar Kayali, Egemen Orkun Sadan, Betul Sen, Elif Subasi   +7 more
doaj   +1 more source

Synthesis, Spectroscopic Characterization, Structural Studies, and In Vitro Antitumor Activities of Pyridine-3-carbaldehyde Thiosemicarbazone Derivatives

Journal of Chemistry, 2020
Eight new thiosemicarbazone derivatives, 6-(1-trifluoroethoxy)pyridine-3-carbaldehyde thiosemicarbazone (1), 6-(4′-fluorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (2), 5-chloro-pyridine-3-carbaldehyde thiosemicarbazone (3), 2-chloro-5-bromo ...
Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Maik Icker, Harald Krautscheid, Lothar Beyer   +7 more
doaj   +1 more source

Crystal structure of 4-hydroxy-3-methoxybenzaldehyde 4-methylthiosemicarbazone methanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title solvate, C15H15N3O2S·CH3OH, the thiosemicarbazone molecule is approximately planar; the maximum deviation from the mean plane is 0.4659 (14) Å and the dihedral angle between the aromatic rings is 9.83 (8)°.
Adriano Bof de Oliveira, Johannes Beck, Christian Landvogt, Bárbara Regina Santos Feitosa   +3 more
doaj   +1 more source

Selective Metal Chelation by a Thiosemicarbazone Derivative Interferes with Mitochondrial Respiration and Ribosome Biogenesis in Candida albicans

Microbiology Spectrum, 2022
Metal chelation is generally considered as a promising antifungal approach but its specific mechanisms are unclear. Here, we identify 13 thiosemicarbazone derivatives that exert broad-spectrum antifungal activity with potency comparable or superior to ...
Ximeng Duan, Zhiyu Xie, Liying Ma, Xueyang Jin, Ming Zhang, Yuliang Xu, Yue Liu, Hongxiang Lou, Wenqiang Chang   +8 more
doaj   +1 more source