Results 41 to 50 of about 9,384 (213)

Synthesis and in vitro Biological Assessments of Novel Thiazole-Based Thiosemicarbazone Complexes

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
In the present work, novel heterocyclic thiazole-based thiosemicarbazone Ag(I) complexes (Hc1, Hc2, Hc3) were obtained using the template method. The structures of synthesized thiosemicarbazone compounds were determined by some spectroscopic techniques ...
Dilek Nartop, Elvan Hasanoğlu Özkan, Hatice Öğütçü, Nurdan Kurnaz Yetim   +3 more
doaj   +1 more source

Synthesis, Cytotoxic Activity, mRNA Expression, Total Oxidant and Antioxidant Status, and Molecular Modeling Studies of Novel Schiff Base–Thiosemicarbazone Hybrids

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In this study, new Schiff base‐derived compounds were synthesized, and their structures were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and HRMS analyses. The cytotoxic effects of the compounds on a prostate cancer cell line (PC3) were investigated, and it was determined that the compounds NZ10, NZ9, NZ7, and NZ4, in particular, exhibited potent anticancer ...
Anber M Anber, Mehmet Özbay, İlhan Özer İlhan, Hüseyin Kekeçmuhammed, Rıfat Emin Bora, Emin Saripinar, Yalçın Erzurumlu, Muhammed Tilahun Muhammed, Sadeq K. Alhag, Lamya Ahmed Alkeridis, Senem Akkoc   +10 more
wiley   +1 more source

Synthesis and X-ray Crystal Structure of the Thiosemicarbazone L bis(4-N-Methyl-Thiosemicarbazone)-4,4'-Diacetylphenylmethane [PDF]

, 2015
The 18th International Electronic Conference on Synthetic Organic Chemistry session Polymer and Supramolecular ChemistryWe report herein the synthesis of the tetradentate thiosemicarbazone ligand bis(4-N-methyl-thiosemicarbazone)-4,4 ...
Gómez Fórneas, Esther, Pedrido Castiñeiras, Rosa María, Maneiro Maneiro, Marcelino, Carballido Piñeiro, Rocío, Bermejo Patiño, Manuel Rafael   +4 more
core   +1 more source

Antimicrobial, antibiofilm, docking, DFT and molecular dynamics studies on click-derived isatin-thiosemicarbazone-1,2,3-triazoles

, 2023
In an effort to develop new antimicrobial and antibiofilm agents, we have designed and synthesized a novel class of isatin-thiosemicarbazone-1,2,3-triazoles through the CuAAC approach.
Mohd Murtaza (13230741), Aman Kumar (762642), Kashmiri Lal (2442955), Sundeep Jaglan (2569399), Madhur Babu Singh (11988250), Yajat Rohila (16964447), Prashant Singh (729773), Kamlesh Kumari (7215059)   +7 more
core   +1 more source

Synthesis, Moleculer Modeling, and Carbonic Anhydrase Inhibitor Effects of Novel 1‐(1‐benzyl‐2‐oxoindolin‐3‐ylidene)‐4‐(3‐sulfamoylphenyl)thiosemicarbazides

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Novel 1‐(1‐benzyl‐2‐oxoindolin‐3‐ylidene)thiosemicarbazides (6a–l) bearing a 3‐sulfamoylphenyl moiety selectively inhibited the tumor‐associated hCA IX and XII isoforms over hCA I and II isoforms at the nanomolar levels. Compounds 6k and 6f emerged as the most potent inhibitors of hCA IX and XII, respectively.
Çağla Begüm Apaydın, Tuğçe Cinek, Hayrunnisa Nadaroğlu, Nilgün Karalı   +3 more
wiley   +1 more source

Zinc(II)–thiosemicarbazone complexes are localized to the lysosomal compartment where they transmetallate with copper ions to induce cytotoxicity

, 2016
As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone (ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their fluorescent zinc(II) complexes to assess their intracellular distribution. The
Duraippandi Palanimuthu (1992139), Stacy, Alexandra E., Bernhardt, Paul V, Richardson, Des R., Palanimuthu, Duraippandi, Bernhardt, Paul V., Patric J. Jansson (2051296), Des R. Richardson (141026), Stacy, Alexandra E, Danuta S. Kalinowski (525221), Richardson, Des R, Alexandra E. Stacy (2626402), Jansson, Patric J, Kalinowski, Danuta S., Jansson, Patric J., Kalinowski, Danuta S, Paul V. Bernhardt (1435054)   +16 more
core   +1 more source

The Effect of the Serum Amino Acid Levels Thiosemicarbazone Derivatives and its Metal Complexes on Rats

Medicine Science, 2013
Advers biological activities of Thiosemicarbazone (TSC) and Schiff base (SB) derivatives have been widely studied in rats and in other animal species using different doses, times and routes of administration.
Mustafa Karatepe, Dilara Kaman
doaj   +1 more source

Thiosemicarbazones with tyrosinase inhibitory activity [PDF]

MedChemComm, 2019
Thiosemicarbazones reveal strong anti-tyrosinase activity.
Katarzyna Hałdys, Rafał Latajka
openaire   +2 more sources

Synthesis, Characterization, Electrochemical Studies, and In Vitro Antibacterial Activity of Novel Thiosemicarbazone and Its Cu(II), Ni(II), and Co(II) Complexes

The Scientific World Journal, 2014
Metal complexes were prepared by the reaction of thiosemicarbazone with CuCl2, NiCl2, CoCl2, Cu(OAc)2, Ni(OAc)2, and Co(OAc)2. The thiosemicarbazone coordinates to metal through the thionic sulfur and the azomethine nitrogen.
Salman A. Khan, Abdullah M. Asiri, Khalid Al-Amry, Maqsood Ahmad Malik   +3 more
doaj   +1 more source

Recent Advances in Chemosensors Bearing Pyrazole and Imidazole Rings: An Approach Toward the Detection of Metal Ions Based on these Diazoles

Advanced Sensor Research, Volume 5, Issue 10, October 2026.
This contribution analyzes recent articles (2021–2025) on chemosensors containing pyrazole and imidazole rings for detecting metal ions, using distinctive examples. It focuses on the structural design of probes, their coordination behavior, sensing mechanisms, and analytical performance, including selectivity, sensitivity, working wavelength, and ...
Alexander Ladino‐Bejarano, Carlos Cifuentes, Néstor Bravo, Jaime Portilla   +3 more
wiley   +1 more source