Results 61 to 70 of about 7,932 (222)

Synthesis, Characterization, Electrochemical Studies, and In Vitro Antibacterial Activity of Novel Thiosemicarbazone and Its Cu(II), Ni(II), and Co(II) Complexes

The Scientific World Journal, 2014
Metal complexes were prepared by the reaction of thiosemicarbazone with CuCl2, NiCl2, CoCl2, Cu(OAc)2, Ni(OAc)2, and Co(OAc)2. The thiosemicarbazone coordinates to metal through the thionic sulfur and the azomethine nitrogen.
Salman A. Khan, Abdullah M. Asiri, Khalid Al-Amry, Maqsood Ahmad Malik   +3 more
doaj   +1 more source

Chemical structure of 4,4’-dimethoxybenzophenone thiosemicarbazone (T44Bf).

, 2015
Chemical structure of 4,4’-dimethoxybenzophenone thiosemicarbazone (T44Bf).
Carlos Davio (705605), Natalia Gomez (705602), Albertina Moglioni (547262), Maia Cabrera (705603), Federico Remes Lenicov (337979), Emiliana Echeverría (794349), Carina Shayo (705604), Natalia Fernández (5662648)   +7 more
core   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Antidiabetic Evaluation of Thiosemicarbazone Analogs Through α‐Amylase Inhibition Complemented With Computational Studies

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Thiosemicarbazones were evaluated for antidiabetic activity via α‐amylase inhibition. Compound 6g showed two‐fold greater potency than acarbose. Benzaldehyde‐ and ketone‐derived analogues were most active, while isatin and furan derivatives were less effective. Several compounds displayed antioxidant activity. Docking highlighted hydrogen bonding and π–
Neha Manhas, Gobind Kumar, Ankit, Nagaraju Kerru, Pule Seboletswe, Nontobeko Gcabashe, Almahi Idris, Md. Shahidul Islam, Talent Makhanya, Parvesh Singh   +9 more
wiley   +1 more source

Thermodynamic Study of Complexation of Furoin-thiosemicarbazone and Furoin-4- phenyl-3-thiosemicarbazone with Bivalent Metal Ions

, 1991
Department of Chemistry, Shivaji University, P. G. Centre, Solapnr-413 004 Department of Chemistry, Shivaji University, Kolhapnr-416 004 Manuscript received 14 February 1991, revised 22 August 1991, accepted 20 September 1991 Thermodynamic Study of ...
L. P. DBSHMUKH, A. H. MANIKSHETE, P. P. HANKARE, R. S. RAMPURE, M.B.CHAVAN   +4 more
core   +1 more source

CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi, Fernand A. Gbaguidi, Bienvenu Glinma   +5 more
doaj  

Synthesis, Spectral and Magnetic Studies of Newly Mixed-Ligand Complexes of 4-Formyl-Acetanilide Thiosemicarbazone and 3,4-Dihydrocinnamic Acid with Some Metal Ions

E-Journal of Chemistry, 2010
New complexes with thiosemicarbazone derivative and 3, 4-dihydrocinnamic acid were prepared and characterized by elemental analysis, determination of metal, IR, 1H NMR, electronic spectroscopy and magnetic measurements.
Shayma A. Shaker
doaj   +1 more source

Ferrocene-1-carbaldehyde thiosemicarbazone

Acta Crystallographica Section E, 2010
The asymmetric unit of the title compound, [Fe(C5H5)(C7H8N3S)], consists of two crystallographically independent molecules, A and B. The cyclopentadienyl (Cp) rings in both molecules adopt an eclipsed conformation and are parallel to each other, forming ...
M. R. Vikneswaran, Siang Guan Teoh, Chin Sing Yeap, Hoong-Kun Fun   +3 more
doaj   +1 more source

Potential Biological Targets of Anticancer Metal‐Based Drug Candidates: A Systematic Review

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT The discovery of Cisplatin marked the beginning of the metallodrug era in oncology. Despite their clinical success, platinum‐based compounds present important limitations, including drug resistance and systemic toxicity. These challenges have stimulated interest in alternative metal complexes capable of interacting with biomolecular targets ...
Allysson L. dos S. Ferreira, Bruna B. Dantas, Jailton De Souza‐Ferrari, Edilson B. Alencar Filho   +3 more
wiley   +1 more source

Phytochemical Characterization and Neuropharmacological Assessment of Combretum indicum Methanolic Extract With Integrated Molecular Docking and Dynamics Simulation for Anxiety and Depression Therapy

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Graphical abstract illustrating the preparation of methanolic extract from the whole plant of Combretum indicum, followed by phytochemical characterization using GC–MS and FTIR analyses. The study integrates in vivo neuropharmacological investigations with in silico computational approaches, including molecular docking, ADMET profiling, PASS prediction,
Zobayed Islam, Md. Ashraful Alam, Sakib Ahamed Bhuiyan, Sabikun Naher, Nilufar Sultana, S. M. Naim Uddin   +5 more
wiley   +1 more source