Results 1 to 10 of about 2,427 (174)

Electrochemical Behavior of Some Substituted Thiosemicarbazones and Their Reaction Products With Tetracyanoethylene

International Journal of Electrochemical Science, 2008
The electrochemical behavior of substituted thiosemicarbazones has been investigated. It is found that the cyclic voltammetry of all substitutions is different; this can be attributed to the nature of terminal aldehydic group.
S A M Refaey
exaly   +4 more sources

Chemical Scaffolds Driving Modern Anticancer Drug Discovery and Radiotheranostics: Structural Determinants, Translational Opportunities and Future Perspectives [PDF]

Pharmaceuticals
Cancer remains one of the leading causes of morbidity and mortality worldwide despite advances in molecular oncology and targeted therapeutics. The growing demand for precision medicine has accelerated the development of radiotheranostics, an emerging ...
Marta Rusek
doaj   +2 more sources

Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Twelve thiosemicarbazones and 24 corresponding Cu(II) and Pd(II) complexes were synthesised and evaluated for their physicochemical properties and biological activities.
Bartłomiej Rogalewicz, Magdalena Iwan, Marcin Świątkowski, Mariola Michalczuk, Joanna Kubik, Ewelina Humeniuk, Agnieszka Korga-Plewko, Monika Pitucha, Tomasz Boruta, Tomasz Sierański, Jakub Kubicki, Sylwia Ścieszka, Edyta Kordialik-Bogacka, Agnieszka Czylkowska   +13 more
doaj   +2 more sources

In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease [PDF]

Pharmaceutics
Background/Objectives: Chagas disease remains a major unmet medical need due to the limited efficacy and safety of current therapies. Here, we investigated sixteen thiosemicarbazone (TSC) derivatives as cruzain inhibitors using an integrated in silico/in
Lidiane Meier, Milena F. C. V. de Melo, Heitor R. Abreu, Isabella M. e Oliveira, Larissa Sens, Thiago H. Doring, Renata Krogh, Adilson Beatriz, Adriano D. Andricopulo, Sumbal Saba, Aldo S. de Oliveira, Jamal Rafique   +11 more
doaj   +2 more sources

Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones [PDF]

Journal of the Serbian Chemical Society, 2021
In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR ...
Čobeljić Božidar R., Živković Marijana B., Matić Ivana Z., Novaković Irena T., Sladić Dušan M., Anđelković Katarina K., Krstić Natalija M.   +6 more
doaj   +1 more source

Functionalizing Thiosemicarbazones for Covalent Conjugation

Molecules
Thiosemicarbazones (TSCs) with their modular character (thiosemicarbazides + carbonyl compound) allow broad variation of up to four substituents on the main R1R2C=N(1)–NH–C(S)–N(4)R3R4 core and are thus interesting tools for the formation of conjugates ...
Johannes Hohnsen, Lukas Rryci, Diana Obretenova, Joshua Friedel, Shahab Jouchaghani, Axel Klein   +5 more
doaj   +3 more sources

Synthesis and Antioxidant Activity of Novel Thiazole and Thiazolidinone Derivatives with Phenolic Fragments

Applied Sciences, 2023
In this work, a series of thiosemicarbazones with phenol fragments were used as starting compounds for the synthesis of new effective antioxidants containing both a phenol substituent and a heterocyclic fragment: thiazole and thiazolidinone. To determine
Vladimir N. Koshelev, Olga V. Primerova, Stepan V. Vorobyev, Anna S. Stupnikova, Ludmila V. Ivanova   +4 more
doaj   +1 more source

Synthesis of New of 4-Thiazolidinone and Thiazole Derivatives Containing Coumarin Moiety with Antimicrobial Activity

Acta Chimica Slovenica, 2023
Synthesizing hybrid molecules is one the best manner to achieve novel promising agents. Consequently, series of new thiazoles having coumarin nucleus were synthesized from 3-acetylcoumarin thiosemicarbazones. Cyclization of thiosemicarbazone derivatives
Reem Al-Harbi, Marwa El-Sharief, Samir Abbas   +2 more
doaj   +1 more source

SYNTHESIS, CHARACTERIZATION AND THERMAL STUDIES OF MIXED LIGAND COMPLEXES OF Hg(II) THIOSEMICARBAZONES WITH 2-AMINOTHIAZOLE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2009
Several Hg(II) mixed ligand complexes of thiosemicarbazones (2-acetylpyridine-, 4-aminoacetophenone- and 2-furaldehyde thiosemicarbazones) with 2-aminothiazole have beenprepared.
Kamal Al-Jadabi
doaj   +1 more source

Monosubstituted Acetophenone Thiosemicarbazones as Potent Inhibitors of Tyrosinase: Synthesis, Inhibitory Studies, and Molecular Docking

Pharmaceuticals, 2021
A set of 12 monosubstituted acetophenone thiosemicarbazone derivatives (TSCs) were synthesized and their inhibitory properties toward tyrosinase activity were tested.
Katarzyna Hałdys, Waldemar Goldeman, Natalia Anger-Góra, Joanna Rossowska, Rafał Latajka   +4 more
doaj   +1 more source