Results 41 to 50 of about 2,427 (174)

Exploring the synthesis, characterization, and corrosion inhibition of new tris-thiosemicarbazone derivatives for acidic steel settings using computational and experimental studies

Scientific Reports
A novel two tri-thiosemicarbazones derivatives, namely 2,2',2''-((2-Hydroxybenzene-1,3,5-triyl)tris(methanylylidene))tris(N-benzylhydrazine-1-carbothioamide) (HBC) and 2,2',2''-((2-hydroxybenzene-1,3,5-triyl) tris (methanylylidene)) tris (N ...
Ahmed M. Abuelela, Mahmoud A. Bedair, Ehab S. Gad, Y. F. El-Aryan, Wael Abdelgayed Ahmed Arafa, Asmaa K. Mourad, H. Nady, Salah Eid   +7 more
doaj   +1 more source

Synthesis, Crystal Structural Investigations, and DFT Calculations of Novel Thiosemicarbazones

Crystals, 2016
The crystal and molecular structures of three new thiosemicarbazones, 2-[1-(2-hydroxy-5-methoxyphenyl)ethylidene]-N-methyl-hydrazinecarbothioamide monohydrate (1), 2-[1-(2-hydroxy-5-methoxyphenyl)ethylidene]-N-ethyl-hydrazinecarbothioamide (2) and 2-[1 ...
Brian J. Anderson, Jerry P. Jasinski, Michael B. Freedman, Sean P. Millikan, Kelly A. O’Rourke, Victoria A. Smolenski   +5 more
doaj   +1 more source

Synthesis, characterization, antibacterial activity of thiosemicarbazones derivatives and their computational approaches: Quantum calculation, molecular docking, molecular dynamic, ADMET, QSAR

Heliyon, 2023
The thiosemicarbazones and their derivatives have been recognized as antimicrobial agents against human pathogenic bacteria and fungi. Regarding these prospective, this study was designed to address the new antimicrobial agents from thiosemicarbazones ...
Mahbub Alam, Mohammed Nurul Abser, Ajoy Kumer, Md Mosharef Hossain Bhuiyan, Parul Akter, Md Emdad Hossain, Unesco Chakma   +6 more
doaj   +1 more source

A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih, Anguraj Moulishankar, Chee Yan Choo, Khang Wen Goh, Chrismawan Ardianto, Azam Che Idris, Long Chiau Ming   +6 more
wiley   +1 more source

Synthesis, absorption, distribution, metabolism, excretion and antioxidant assay of some N4 –substituted thiosemicarbazones of cinnamaldehyde

One Health & Risk Management
Introduction. The increasing number of cancer diagnoses is a pressing issue in modern medicine. One contributing factor to cancer development is oxidative stress caused by free radicals, which can damage proteins, lipids, and DNA.
Andrei CIURSIN, Roman RUSNAC, Aurelian GULEA   +2 more
doaj   +1 more source

Investigation of the Biological Properties of (Hetero)Aromatic Thiosemicarbazones

Molecules, 2012
Two series of thiosemicarbazone-based iron chelators (twenty-seven compounds) were designed and synthesized using a microwave-assisted approach. Quinoline and halogenated phenyl were selected as parent scaffolds on the basis of a similarity search.
Jaroslaw Polanski, Marcela Vejsova, Alicja Ratuszna, Robert Musiol, Katarina Kralova, Matus Pesko, Josef Jampilek, Anna Mrozek-Wilczkiewicz, Maciej Serda   +8 more
doaj   +1 more source

Benzoin thiosemicarbazone

Acta Crystallographica Section E Structure Reports Online, 2005
In the title compound, C15H15N3OS, the thio­semicarbazone moiety is planar, with a maximum deviation of 0.0369 (11) A, and has an E configuration. The planar phenyl rings make dihedral angles of 26.56 (9) and 81.20 (5)° with the plane of the thio­semicarbazone moiety. In the mol­ecule, there are two intramolecular interactions of types N—H⋯O and N—H⋯N.
Dincer, M, Ozdemir, N, Cukurovali, A, Yilmaz, I   +3 more
openaire   +2 more sources

Synthesis, Characterization, and DFT of Some Thiazole Derivatives as Carbon Steel Corrosion Inhibitors in 1 M HCl

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
By reacting 2‐(1‐(4‐aminophenyl)ethylidene)hydrazine‐1‐carbothioamide (1) with various α‐halocarbonyl compounds, such as 3‐chloropentane‐2,4‐dione 2 and 1‐chloro‐1‐((4‐substituted phenyl)diazenyl)propan‐2‐one 4a–c, this work produces a new series of thiazole derivatives 3 and 5a–c.
Ahmed O. Mahmoud, Ghada Y. Elewady, Ahmed E. Suliman, Abdelfattah M. Ouf, Ghada E. Abdel‐Ghani   +4 more
wiley   +1 more source

Structural Studies of 2,6-Diacetyl- and 2,6-Diformylpyridine Bis(thiosemicarbazones)

Journal of the Brazilian Chemical Society, 2002
Although a large number of crystal structures of heterocyclic thiosemicarbazones have recently appeared in the literature, few structures of heterocyclic bis(thiosemicarbazones) or their metal complexes have been reported.
Brown Christine A., Kaminsky Werner, Claborn Kacey A., Goldberg Karen I., West Douglas X.   +4 more
doaj  

Synthesis, In Vitro Antitumor Activity, and In Silico ADMET Evaluation of β-Lapachone-Based Thiosemicarbazones

Drugs and Drug Candidates
Background/Objectives: β-Lapachone and triapine are compounds with recognized antitumor potential—the former is an ortho-naphthoquinone, and the latter a thiosemicarbazone inhibitor of ribonucleotide reductase. This study aimed to synthesize and evaluate
Elizabete Silva de Sousa, Edilane Almeida da Silva, Délis Galvão Guimarães, Ingrid Louise Santos de Souza, Arlan de Assis Gonsalves, Paulo Michel Pinheiro Ferreira, Rayran Walter Ramos de Sousa, Marcília Pinheiro da Costa, Cleônia Roberta Melo Araújo   +8 more
doaj   +1 more source