Results 41 to 50 of about 14,086 (252)

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development

Antioxidants and Redox Signaling, 2018
Significance: During the past decades, thiosemicarbazones were clinically developed for a variety of diseases, including tuberculosis, viral infections, malaria, and cancer.
P. Heffeter, Veronika F. S. Pape, É. A. Enyedy, B. Keppler, G. Szakács, C. Kowol   +5 more
semanticscholar   +1 more source

Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The development of skin-care products is recently growing. Cosmetic formulas containing active ingredients with proven efficacy, namely cosmeceuticals, are based on various compounds, including peptides.
Patrycja Ledwoń, Waldemar Goldeman, Katarzyna Hałdys, Michał Jewgiński, Greta Calamai, Joanna Rossowska, Anna Maria Papini, Paolo Rovero, Rafał Latajka   +8 more
doaj   +1 more source

Novel isatin–triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies

RSC Advances
Thiosemicarbazones of isatin have been found to exhibit versatile bioactivities. In this study, two distinct types of isatin–triazole hybrids 3a and 3b were accessed via copper-catalyzed azide–alkyne cycloaddition reaction (CuAAC), together with their ...
A. Mushtaq, Rabbia Asif, Waqar Ahmed Humayun, Muhammad Moazzam Naseer   +3 more
semanticscholar   +1 more source

A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds

Journal of New Results in Science
Thiosemicarbazones can be synthesized by condensation of thiosemicarbazides with ketones or aldehydes and play a role as precursors in the synthesis of many compounds such as thiazoles.
Gürsel Korkmaz
doaj   +1 more source

COMPUȘI COORDINATIVI AI CUPRULUI(II) CU TIOSEMICARBAZONE ALE 2-FORMILPIRIDINEI ȘI DERIVAȚILOR EI

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2021
În articol este efectuată analiza literaturii de specialitate privind sinteza, caracterizarea structurală și proprietățile bio­lo­gice ale compușilor coordinativi ai cuprului(II) în baza tiosemicarbazonelor 2-formilpiridinei și a derivaților ei.
Elena NEGUȚA
doaj  

Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration [PDF]

, 2019
Objectives: Drug resistance exists to all current and investigational antimalarial drug classes. Consequently, we have set out to develop chemically and mechanistically discrete antimalarials.
Chavchich, Marina, de Kock, Carmen, Birrell, Geoffrey W, Edstein, Michael D, Richardson, Des R, Parkinson, Christopher J, Mackenzie, Donna, Haynes, Richard K   +7 more
core   +1 more source

Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding [PDF]

, 2020
Considering the role of proto-oncogene c-Met (c-Met) in oncogenesis, we examined the effects of the metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), and two NDRG1-inducing thiosemicarbazone-based agents, Dp44mT and DpC, on c-Met ...
Geleta, B, Richardson, DR, Jansson, PJ, Leck, LYW, Paluncic, J, Chiang, S, Park, KC, Kovacevic, Z   +7 more
core   +1 more source

IN VITRO study of copper coordination compounds with thiosemicarbazone action on antioxidant enzymes

One Health & Risk Management
Introduction. Thiosemicarbazones represent a class of organic compounds with significant pharmacological potential, known for their antitumor, antimicrobial, and antiviral activities.
Valeriana PANTEA, Ecaterina PAVLOVSCHI, Silvia STRATULAT, Olga TAGADIUC, Valentin GUDUMAC   +4 more
doaj   +1 more source

Influence of the Reaction Conditions in the Crystal Structures of Zn(II) and Ni(II) Coordination Compounds with a Dissymmetric Bis(Thiosemicarbazone) Ligand

Crystals, 2022
The new ligand HMeATSM, derived from condensation of 2-3-butanedione with 4-methyl-3-thiosemicarbazide and 2,4-dimethyl-3-thiosemicarbazide, has been synthesized.
Luis Alonso, Rodrigo Burón, Elena López-Torres, Maria Antonia Mendiola   +3 more
doaj   +1 more source

Potential leishmanicidal of the thiosemicarbazones: A review

Results in Chemistry
Thiosemicarbazones constitute a class of organic compounds with the general structure R=N-NH-CS-NHR and are known for their biological properties, making them an important structure for drug development. This work presents a systematic review of the main
Edilane Almeida da Silva, Ismael Holanda do Vale, Elizabete Silva Sousa, Sidney Silva Simplicio, Arlan de Assis Gonsalves, Cleônia Roberta Melo Araújo   +5 more
doaj   +1 more source