Results 51 to 60 of about 7,220 (228)

From Design to Bioactivity: 2‐Benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone and Its 3d Metal Coordination Compounds

ChemistryOpen, Volume 15, Issue 4, April 2026.
The new 2‐benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone (HL) and its copper(II), nickel(II), cobalt(III), and iron(III) coordination compounds [Cu(L)Cl] (1), [Cu(L)NO3] (2), {[Cu(L)(Cl2CHCOO)]}n (3), [Ni(HL)2](NO3)2 (4), [Fe(L)2]NO3 (5), [Co(L)2]NO3 (6) were obtained.
Ianina Graur, Vasilii Graur, Elena Melnic, Carolina Lozan‐Tirsu, Greta Balan, Victor Tsapkov, Aurelian Gulea   +6 more
wiley   +1 more source

Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides [PDF]

, 2014
This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including ...
Fidecka, Sylwia, Kuśmierz, Edyta, Kędzierska, Ewa, Orzelska, Jolanta, Paneth, Agata, Paneth, Piotr, Plech, Tomasz, Wróbel, Andrzej, Wujec, Monika   +8 more
core   +2 more sources

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei [PDF]

, 2011
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Bienvenu Glinma, Fernand A. Gbaguidi, Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi   +5 more
core  

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms [PDF]

, 2016
Background Neuroblastoma is a relatively common and highly belligerent childhood tumor with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2-pyridylketone thiosemicarbazone series, namely di-2-pyridylketone 4,4 ...
Danuta S. Kalinowski, Des R. Richardson, Godfrey Chi-Fung Chan, Kian Cheng Tan-Un, Zaklina Kovacevic, Zhu-Ling Guo   +5 more
core   +3 more sources

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, Volume 73, Issue 1, Page 14-27, February 2026.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

Current and future chemotherapy for Chagas disease [PDF]

, 2015
Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela, Coron, Ross P, Costantino, Luca, Costi, Maria Paola, Ferrari, Stefania, Freitas-Junior, Lucio H, Gaspar, Luís, McKerrow, James H, Moraes, Carolina B, Siqueira-Neto, Jair L, Smith, Terence Kenneth   +10 more
core   +1 more source

Polysaccharide‐Coated ETCA Nanoparticles Containing the Methoxyl Substituted Indole‐Thiazole Derivative and Their Antiproliferative Activity in Breast Cancer Cells

Journal of Applied Polymer Science, Volume 143, Issue 4, January 20, 2026.
ABSTRACT Indole and thiazole derivatives have garnered significant attention due to their potent antitumor activities. Encapsulation of such derivatives into polymeric nanoparticles offers several advantages, including improved molecular stability and targeted delivery to tumor sites, thereby enhancing their antineoplastic potential.
José Cleberson Santos Soares, Iago Dillion Lima Cavalcanti, Iranildo José da Cruz‐Filho, Mariane Cajubá de Britto Lira Nogueira, Maria do Carmo Alves de Lima   +4 more
wiley   +1 more source

Synthesis, Crystal Structural Investigations, and DFT Calculations of Novel Thiosemicarbazones

Crystals, 2016
The crystal and molecular structures of three new thiosemicarbazones, 2-[1-(2-hydroxy-5-methoxyphenyl)ethylidene]-N-methyl-hydrazinecarbothioamide monohydrate (1), 2-[1-(2-hydroxy-5-methoxyphenyl)ethylidene]-N-ethyl-hydrazinecarbothioamide (2) and 2-[1 ...
Brian J. Anderson, Jerry P. Jasinski, Michael B. Freedman, Sean P. Millikan, Kelly A. O’Rourke, Victoria A. Smolenski   +5 more
doaj   +1 more source

Evaluation of a New Methylimidazole‐Containing Thiosemicarbazone as a Cu+/Cu2+‐Targeting Ligand in the Context of Alzheimer's Disease

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
HXE modulates Cu(Aβ) interaction, reducing ROS production and shifting peptide aggregation in the presence of Cu from toxic amorphous aggregates to less harmful fibrillar structures. These findings highlight HXE potential to interfere with Cu‐induced oxidative stress and aggregation pathways relevant to AD.
Barbara Marinho Barbosa, Charlène Esmieu, Antal Galvácsi, Mariana Viana Costa, Adèle Brison, Sonia M. Ladeira, Jade de Oliveira, Csilla Kállay, Christelle Hureau, Nicolás A. Rey   +9 more
wiley   +1 more source