Results 51 to 60 of about 2,427 (174)

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

Molecules, 2013
New imidazole derived thiosemicarbazones and hydrazones were prepared by condensation of 4(5)-imidazole carboxaldehyde, 4-(1H-imidazole-1-yl)benzaldehyde and 4-(1H-imidazole-1-yl)acetophenone with a thiosemicarbazide or hydrazide.
Jacqueline A. Takahashi, Isolda C. Mendes, Camila F. Vilela, Nayane F. Silva, Jeferson G. Da Silva, Angel A. Recio Despaigne, Débora C. Reis, Heloisa Beraldo   +7 more
doaj   +1 more source

Transalkylidation reaction: green, catalyst-free synthesis of thiosemicarbazones and solving the NMR conflict between their acyclic structure and intramolecular cycloaddition products

Green Chemistry Letters and Reviews, 2019
A series of arylidene thiosemicarbazides have been prepared by a new method, which was titled as transalkylidation. This method is an effective, fast, green and clean method. The mechanism of this reaction has been discussed.
Mohamed A. El-Atawy, Alaa Z. Omar, Mohamed Hagar, Essam M. Shashira   +3 more
doaj   +1 more source

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis

Molecules, 2019
Co-infection of malaria and tuberculosis, although not thoroughly investigated, has been noted. With the increasing prevalence of tuberculosis in the African region, wherein malaria is endemic, it is intuitive to suggest that the probability of co ...
Richard M. Beteck, Ronnett Seldon, Audrey Jordaan, Digby F. Warner, Heinrich C. Hoppe, Dustin Laming, Setshaba D. Khanye   +6 more
doaj   +1 more source

Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1076-1089, September 2026.
This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley   +1 more source

Synthesis, Characterization, Crystal Structures and Urease Inhibition of Thiosemicarbazones

Acta Chimica Slovenica
Thiosemicarbazones are biological active compounds. Six new thiosemicarbazones were prepared and structurally characterized by elemental analysis, 1H NMR and IR spectra, as well as single crystal X-ray diffraction.
Ling-Wei Xue, Qiao-Ru Liu, Yong-Jun Han
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Anthracene Derivatives as Potent Antioxidants: Experimental, DFT, and Docking Studies

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A series of anthracene‐based derivatives exhibited exceptional antioxidant activity, with IC50 values surpassing ascorbic acid. DFT and molecular docking studies revealed efficient charge transfer and strong Keap1/Nrf2 binding, highlighting their potential as promising therapeutic agents against oxidative stress.
Mohamed R. Elmorsy, Menna Moustafa, Hassan A. Etman, Nashwa M. El‐Metwaly, Safa A. Badawy   +4 more
wiley   +1 more source

Synthesis of thiosemicarbazone derivatives and evaluation of their cytotoxicity with emphasis on ferroptosis biomarkers; an in vitro study

Research in Pharmaceutical Sciences
Background and purpose: This study aimed to evaluate the cytotoxicity of synthesized thiosemicarbazone derivatives, particularly on biomarkers associated with ferroptosis.
Yasaman Shadmani, Yaghoub Pourshojaei, Somayyeh Karami-Mohajeri, Bagher Amirheidari, Motahareh Sadeghzadeh   +4 more
doaj   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

A Tale of Two Mechanisms: The p53 Modulator COTI‐2 Is a Zn Metallochaperone

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. Tp53 mutations often induce conformational changes that inhibit activity; however, small‐molecule chaperones could theoretically restore conformation and activity. COTI‐2,
İrem Şimşek, Farsheed Shahbazi‐Raz, Michael J. Krause, Azam Mohammadzadeh, Maryam Kosar, Peihan Xu, Samra Khan, Olena Tykhoniuk, Ashley DaDalt, Deya'a Almasri, Lara K. Watanabe, Kaitlyn Breault, John J. Hayward, Fraser S. Pick, Richard L. Ho, Jeremy M. Rawson, John F. Trant   +16 more
wiley   +1 more source

Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT Emetine (EMT), a naturally occurring tetrahydroisoquinoline alkaloid, shows diverse biological actions, including anticancer effects. Despite existing studies, the role of EMT derivatives in cancer, particularly in relation to the PI3K/AKT/mTOR signalling pathway, remains largely underexplored.
Mst. Ismatara Khatun, Samy Selim, Asif Hassan Malik, Md. Sakib Al Hasan, Abul Bashar Ripon Khalipha, Noshin Tasnim Yana, Mohammad Y. Alshahrani, Md. Arif Hossain, Imam Hossen Rakib, Anike Chakrabarty, Emon Mia   +10 more
wiley   +1 more source