Results 71 to 80 of about 14,086 (252)

Antidiabetic Evaluation of Thiosemicarbazone Analogs Through α‐Amylase Inhibition Complemented With Computational Studies

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Thiosemicarbazones were evaluated for antidiabetic activity via α‐amylase inhibition. Compound 6g showed two‐fold greater potency than acarbose. Benzaldehyde‐ and ketone‐derived analogues were most active, while isatin and furan derivatives were less effective. Several compounds displayed antioxidant activity. Docking highlighted hydrogen bonding and π–
Neha Manhas, Gobind Kumar, Ankit, Nagaraju Kerru, Pule Seboletswe, Nontobeko Gcabashe, Almahi Idris, Md. Shahidul Islam, Talent Makhanya, Parvesh Singh   +9 more
wiley   +1 more source

Synthesis, absorption, distribution, metabolism, excretion and antioxidant assay of some N4 –substituted thiosemicarbazones of cinnamaldehyde

One Health & Risk Management
Introduction. The increasing number of cancer diagnoses is a pressing issue in modern medicine. One contributing factor to cancer development is oxidative stress caused by free radicals, which can damage proteins, lipids, and DNA.
Andrei CIURSIN, Roman RUSNAC, Aurelian GULEA   +2 more
doaj   +1 more source

Investigation of the Biological Properties of (Hetero)Aromatic Thiosemicarbazones

Molecules, 2012
Two series of thiosemicarbazone-based iron chelators (twenty-seven compounds) were designed and synthesized using a microwave-assisted approach. Quinoline and halogenated phenyl were selected as parent scaffolds on the basis of a similarity search.
Jaroslaw Polanski, Marcela Vejsova, Alicja Ratuszna, Robert Musiol, Katarina Kralova, Matus Pesko, Josef Jampilek, Anna Mrozek-Wilczkiewicz, Maciej Serda   +8 more
doaj   +1 more source

Potential Biological Targets of Anticancer Metal‐Based Drug Candidates: A Systematic Review

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT The discovery of Cisplatin marked the beginning of the metallodrug era in oncology. Despite their clinical success, platinum‐based compounds present important limitations, including drug resistance and systemic toxicity. These challenges have stimulated interest in alternative metal complexes capable of interacting with biomolecular targets ...
Allysson L. dos S. Ferreira, Bruna B. Dantas, Jailton De Souza‐Ferrari, Edilson B. Alencar Filho   +3 more
wiley   +1 more source

Evaluation of Novel Chalcone-Thiosemicarbazones Derivatives as Potential Anti-Leishmania amazonensis Agents and Its HSA Binding Studies

Biomolecules, 2019
A series of seven chalcone-thiosemicarbazones (5a–5g) were synthesized and evaluated as potential new drugs (anti-leishmanial effect). Although four of the chalcone-thiosemicarbazones are already known, none of them or any compound in this class has been
Edinéia Pastro Mendes, Carla Marins Goulart, O. Chaves, V. D. S. Faiões, Marilene M Canto-Carvalho, Gérzia M. C. Machado, E. C. Torres-Santos, A. Echevarria   +7 more
semanticscholar   +1 more source

Synthesis, In Vitro Antitumor Activity, and In Silico ADMET Evaluation of β-Lapachone-Based Thiosemicarbazones

Drugs and Drug Candidates
Background/Objectives: β-Lapachone and triapine are compounds with recognized antitumor potential—the former is an ortho-naphthoquinone, and the latter a thiosemicarbazone inhibitor of ribonucleotide reductase. This study aimed to synthesize and evaluate
Elizabete Silva de Sousa, Edilane Almeida da Silva, Délis Galvão Guimarães, Ingrid Louise Santos de Souza, Arlan de Assis Gonsalves, Paulo Michel Pinheiro Ferreira, Rayran Walter Ramos de Sousa, Marcília Pinheiro da Costa, Cleônia Roberta Melo Araújo   +8 more
doaj   +1 more source

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

Molecules, 2013
New imidazole derived thiosemicarbazones and hydrazones were prepared by condensation of 4(5)-imidazole carboxaldehyde, 4-(1H-imidazole-1-yl)benzaldehyde and 4-(1H-imidazole-1-yl)acetophenone with a thiosemicarbazide or hydrazide.
Jacqueline A. Takahashi, Isolda C. Mendes, Camila F. Vilela, Nayane F. Silva, Jeferson G. Da Silva, Angel A. Recio Despaigne, Débora C. Reis, Heloisa Beraldo   +7 more
doaj   +1 more source

Phytochemical Characterization and Neuropharmacological Assessment of Combretum indicum Methanolic Extract With Integrated Molecular Docking and Dynamics Simulation for Anxiety and Depression Therapy

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Graphical abstract illustrating the preparation of methanolic extract from the whole plant of Combretum indicum, followed by phytochemical characterization using GC–MS and FTIR analyses. The study integrates in vivo neuropharmacological investigations with in silico computational approaches, including molecular docking, ADMET profiling, PASS prediction,
Zobayed Islam, Md. Ashraful Alam, Sakib Ahamed Bhuiyan, Sabikun Naher, Nilufar Sultana, S. M. Naim Uddin   +5 more
wiley   +1 more source

Fluorinated pyrazolinic thiosemicarbazones: selective synthesis and computational analysis [PDF]

Thiosemicarbazones are a class of iminic organosulfur compounds synthesized by condensation reaction between a thiosemicarbazide and an aldehyde or ketone.
Machado, Vanessa Fernandes, Deflon, Victor Marcelo, Miranda, Victor Maia, Marques, Fabio Luiz Navarro   +3 more
core   +2 more sources

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis

Molecules, 2019
Co-infection of malaria and tuberculosis, although not thoroughly investigated, has been noted. With the increasing prevalence of tuberculosis in the African region, wherein malaria is endemic, it is intuitive to suggest that the probability of co ...
Richard M. Beteck, Ronnett Seldon, Audrey Jordaan, Digby F. Warner, Heinrich C. Hoppe, Dustin Laming, Setshaba D. Khanye   +6 more
doaj   +1 more source