Results 71 to 80 of about 4,853 (201)

Synthesis of thiosemicarbazone derivatives and evaluation of their cytotoxicity with emphasis on ferroptosis biomarkers; an in vitro study

Research in Pharmaceutical Sciences
Background and purpose: This study aimed to evaluate the cytotoxicity of synthesized thiosemicarbazone derivatives, particularly on biomarkers associated with ferroptosis.
Yasaman Shadmani, Yaghoub Pourshojaei, Somayyeh Karami-Mohajeri, Bagher Amirheidari, Motahareh Sadeghzadeh   +4 more
doaj   +1 more source

Design, Synthesis of Pyridine Based Thiazolidine Derivatives and Investigation of Antimicrobial Activity Targeting Ergosterol Biosynthesis via In Vitro and In Silico Approaches

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Synthesis of thiazolidine derivatives and investigation of their antimicrobial activities. ABSTRACT Pyridine and thiazolidine ring systems are unique heterocyclic rings since they are present in the structure of various drug/drug‐like molecules and reported in many studies for their distinct biological effects.
Aybüke Züleyha Kaya, Asaf Evrim Evren, Ülküye Dudu Gül, Halide Edip Temel, Leyla Yurttaş   +4 more
wiley   +1 more source

Thiosemicarbazones Target Multiple Resistance Pathways in Cancer [PDF]

, 2016
Multidrug resistance (MDR) is a significant obstacle in the successful treatment of cancer. To date, no therapies that target MDR have reached the clinic.
Stacy, Alexandra Elizabeth
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Trypanocidal and cytotoxic evaluation of synthesized thiosemicarbazones as potential drug leads against sleeping sickness

, 2014
Thiosemicarbazones have become one of the promising compounds as new clinical candidates due to their wide spectrum of pharmaceutical activities. The wide range of their biological activities depends generally on their related aldehyde or ketone groups ...
Accrombessi, Georges C, Glinma, Bienvenu, Kapanda Nankwa, Coco, Kotchoni, Simeon O, Kpoviessi, Sika D S, Gachomo, Emma W, Poupaert, Jacques, Quetin-Leclercq, Joëlle, Baba-Moussa, Lamine, Gbaguidi, Fernand A, Bero, Joanne, Moudachirou, Mansourou   +11 more
core   +1 more source

Urea provides an important nitrogen source for microbial populations in an ultraoligotrophic sea

Limnology and Oceanography, Volume 71, Issue 6, June 2026.
Urea is an organic nitrogen (N) compound directly utilized by both heterotrophic prokaryotes and some photoautotrophs. Reports of either ambient urea concentrations or urea uptake rates from the ultraoligotrophic eastern Mediterranean Sea are lacking. We investigated urea distribution and uptake in the upper water column in the Levantine basin during ...
Alon Blachinsky, Tal Ben Ezra, Shiran Gozali, Anat Tsemel, Dan Tchernov, Mark Altabet, Ilana Berman‐Frank, Michael David Krom   +7 more
wiley   +1 more source

A study on ester thiosemicarbazones

, 1997
The cyclization of ester thiosemicarbazones to two different heterocycles was studied for some new thiosemicarbazones, and only the formation of 1,2,4-triazol-5-thiols was attributed to the regioselectivity of the ring closure reaction, due to a steric ...

core  

Studies on Polymeric Complexes of Cu(II) and Ni(II) with o-Hydroxy Thiosemicarbazones

, 1981
University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002 Manuscript received 12 August 1980, revised 23 February 1981, accepted 13 April 1981 Cu(II) and Ni(ll) complexes with six o-hydroxy thiosemicarbazones such as 2-OH, 5-CH2 aceto/
S. K. THAMPY, L. D. DAVE
core   +1 more source

SYNTHESIS, ANTIOXIDANT ACTIVITY AND ADME ANALYSIS OF SOME N4-SUBSTITUTED THIOSEMICARBAZONES WITH β–IONONE FRAGMENT

Studia Universitatis Moldaviae: Stiinte reale si ale naturii
Thiosemicarbazones are organic compounds with remarkable biological properties, including anticancer, antibiotic, antifungal, and antioxidant effects.
USM ADMIN
doaj  

In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors

Pharmaceuticals
Background/Objectives: Four years after the COVID-19 pandemic, a very limited number of drugs has been marketed; thus, the search for new medications still represents a compelling need.
Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico   +9 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source