Results 81 to 90 of about 14,086 (252)

Synthesis, Characterization, Crystal Structures and Urease Inhibition of Thiosemicarbazones

Acta Chimica Slovenica
Thiosemicarbazones are biological active compounds. Six new thiosemicarbazones were prepared and structurally characterized by elemental analysis, 1H NMR and IR spectra, as well as single crystal X-ray diffraction.
Ling-Wei Xue, Qiao-Ru Liu, Yong-Jun Han
doaj   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Deposition of Zinc Sulfide Thin Films From Zinc(II) Thiosemicarbazones as Single Molecular Precursors Using Aerosol Assisted Chemical Vapor Deposition Technique

Frontiers in Materials, 2019
ZnS thin films have been deposited on a glass substrate by aerosol assisted chemical vapor deposition (AACVD) from the Zinc thiosemicarbazone precursors is reported.
Anil M. Palve
semanticscholar   +1 more source

Thiosemicarbazones Target Multiple Resistance Pathways in Cancer [PDF]

, 2016
Multidrug resistance (MDR) is a significant obstacle in the successful treatment of cancer. To date, no therapies that target MDR have reached the clinic.
Stacy, Alexandra Elizabeth
core  

Targeting redox balance: antioxidant effects of thiosemicarbazones on human peripheral blood [PDF]

Introduction. Thiosemicarbazones represent a class of organic compounds with well-documented pharmacological properties, including antitumor, antimicrobial, and antiviral activities.
Pavlovschi, Ecaterina, Pantea, Valeriana, Gudumac, Valentin, Gulea, Aurelian, Stratulat, Silvia, Tagadiuc, Olga   +5 more
core   +1 more source

Synthesis of thiosemicarbazone derivatives and evaluation of their cytotoxicity with emphasis on ferroptosis biomarkers; an in vitro study

Research in Pharmaceutical Sciences
Background and purpose: This study aimed to evaluate the cytotoxicity of synthesized thiosemicarbazone derivatives, particularly on biomarkers associated with ferroptosis.
Yasaman Shadmani, Yaghoub Pourshojaei, Somayyeh Karami-Mohajeri, Bagher Amirheidari, Motahareh Sadeghzadeh   +4 more
doaj   +1 more source

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives

Biotechnology and Applied Biochemistry, Volume 73, Issue 1, Page 14-27, February 2026.
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Hayreddin Gezegen, Oguz Özbek, Meryem Topal, Hatice Şahin, Ümit M. Koçyiğit   +4 more
wiley   +1 more source

Polysaccharide‐Coated ETCA Nanoparticles Containing the Methoxyl Substituted Indole‐Thiazole Derivative and Their Antiproliferative Activity in Breast Cancer Cells

Journal of Applied Polymer Science, Volume 143, Issue 4, January 20, 2026.
ABSTRACT Indole and thiazole derivatives have garnered significant attention due to their potent antitumor activities. Encapsulation of such derivatives into polymeric nanoparticles offers several advantages, including improved molecular stability and targeted delivery to tumor sites, thereby enhancing their antineoplastic potential.
José Cleberson Santos Soares, Iago Dillion Lima Cavalcanti, Iranildo José da Cruz‐Filho, Mariane Cajubá de Britto Lira Nogueira, Maria do Carmo Alves de Lima   +4 more
wiley   +1 more source

Rhodium assisted C-H activation of benzaldehyde thiosemicarbazones and their oxidation via activation of molecular oxygen [PDF]

, 2006
The benzaldehyde thiosemicarbazones are found to undergo oxidation at the sulfur center upon reaction with [Rh(PPh3)3Cl] in refluxing ethanol in the presence of a base (NEt3).
Falvello, Larry. R., Bhattacharya, Samaresh, Acharyya, Rama, Dutta, Swati, Peng, Shie-Ming, Lee, Gene-Hsiang, Basuli, Falguni   +6 more
core   +1 more source

Evaluation of a New Methylimidazole‐Containing Thiosemicarbazone as a Cu+/Cu2+‐Targeting Ligand in the Context of Alzheimer's Disease

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
HXE modulates Cu(Aβ) interaction, reducing ROS production and shifting peptide aggregation in the presence of Cu from toxic amorphous aggregates to less harmful fibrillar structures. These findings highlight HXE potential to interfere with Cu‐induced oxidative stress and aggregation pathways relevant to AD.
Barbara Marinho Barbosa, Charlène Esmieu, Antal Galvácsi, Mariana Viana Costa, Adèle Brison, Sonia M. Ladeira, Jade de Oliveira, Csilla Kállay, Christelle Hureau, Nicolás A. Rey   +9 more
wiley   +1 more source