Results 81 to 90 of about 7,220 (228)

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

DNA Noncovalent Interactions of Dinuclear η6‐Arene Ru(II) Complexes: Influence of Complex Charge and Bridging Ligand Length on DNA Binding Mode and Cytotoxic Activity

Chemistry – A European Journal, Volume 31, Issue 71, December 17, 2025.
A library of cationic dinuclear Ru(II)‐η⁶‐arene analogues was developed to assess how overall charge and Ru–Ru distance influence DNA binding noncovalent interactions and cytotoxicity. NMR studies showed multiple binding modes with the B‐form DNA oligonucleotide d(5΄‐CGCGAATTCGCG‐3΄)2, while the complexes displayed micromolar IC50 values against MCF‐7,
Dimitrios Thomos, Theodoros Tsolis, John C. Plakatouras, Ioannis‐Michail Chronakis, Angeliki Magklara, Achilleas Garoufis   +5 more
wiley   +1 more source

Investigation of potential anti-radiation and anti-neoplastic compounds related to plant growth regulators second quarterly progress report, 1 oct. 1964 - 1 jan. 1965 [PDF]

Antiradiation and antineoplastic compounds related to plant growth regulators - cytotoxic effects and radiation ...
Norman, D., Schultz, R. D.
core   +1 more source

Spectroscopic, Viscositic and Molecular Modeling Studies on the Interaction of 3′-Azido-Daunorubicin Thiosemicarbazone with DNA [PDF]

, 2013
A new daunorubicin has been synthesized and structurally characterized. The interaction of native calf thymus DNA (ctDNA) with 3′-azido-daunorubicin thiosemicarbazone (ADNRT) was investigated under simulated physiological conditions by multi ...
Fengling Cui, Guisheng Zhang, Hongxia Luo, Qingfeng Liu   +3 more
core   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

ChemistryOpen, Volume 14, Issue 12, December 2025.
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidative damage.
Abdüllatif Karakaya, Ulviye Acar Çevik, Betül Kaya, Bilge Çiftçi, Adem Necip, Mesut Işık, Şükrü Beydemir, Yusuf Özkay, Zafer Asım Kaplancıklı   +8 more
wiley   +1 more source

From actually toxic to highly specific – novel drugs against poxviruses [PDF]

, 2007
The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Sliva, Katja, Schnierle, Barbara
core   +2 more sources

In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors

Pharmaceuticals
Background/Objectives: Four years after the COVID-19 pandemic, a very limited number of drugs has been marketed; thus, the search for new medications still represents a compelling need.
Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico   +9 more
doaj   +1 more source

SYNTHESIS, ANTIOXIDANT ACTIVITY AND ADME ANALYSIS OF SOME N4-SUBSTITUTED THIOSEMICARBAZONES WITH β–IONONE FRAGMENT

Studia Universitatis Moldaviae: Stiinte reale si ale naturii
Thiosemicarbazones are organic compounds with remarkable biological properties, including anticancer, antibiotic, antifungal, and antioxidant effects.
USM ADMIN
doaj  

Synthesis, antibacterial activity and DNA interactions of lanthanide(III) complexes of N(4)-substituted thiosemicarbazones

Universitas Scientiarum, 2018
This paper reports the synthesis and detailed characterization of six novel lanthanide complexes of La(III), Eu(III) and Nd(III) with N(4)-substituted thiosemicarbazones derived from the 2-carboxybenzaldehyde.
Juan-David Londoño-Mosquera, Alberto Aragón-Muriel, Dorian Polo Cerón   +2 more
doaj   +1 more source