Results 91 to 100 of about 14,086 (252)

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.

European journal of medicinal chemistry, 2018
Basing on a library of thiadiazole derivatives showing anti-trypanosomatidic activity, we have considered the thiadiazoles opened forms and reaction intermediates, thiosemicarbazones, as compounds of interest for phenotypic screening against Trypanosoma ...
P. Linciano, C. Moraes, L. Alcântara, C. Franco, B. Pascoalino, L. Freitas-Junior, S. Macedo, N. Santarém, A. Cordeiro-da-Silva, S. Gul, G. Witt, M. Kuzikov, B. Ellinger, S. Ferrari, R. Luciani, A. Quotadamo, L. Costantino, Maria Paola Costi   +17 more
semanticscholar   +1 more source

Antiaflatoxigenic thiosemicarbazones as crop-protective agents: a cytotoxic and genotoxic study. [PDF]

, 2019
Aflatoxins are secondary fungal metabolites that can contaminate feed and food. They are a cause of growing concern worldwide, because they are potent carcinogenic agents.
Rogolino D, Serra O., Buschini A., Pelosi G, Montalbano S, Spadola G, Restivo F. M., Bisceglie F., Carcelli M., Degola F, Bisceglie F, Montalbano S., Zani C., Serra O, Degola F., Feretti D., Restivo FM, Spadola G., Bartoli J, Pelosi G., Carcelli M, Rogolino D., Buschini A, Zani C, Bartoli J., Feretti D   +25 more
core   +3 more sources

SYNTHESIS, ANTIOXIDANT ACTIVITY AND ADME ANALYSIS OF SOME N4-SUBSTITUTED THIOSEMICARBAZONES WITH β–IONONE FRAGMENT

Studia Universitatis Moldaviae: Stiinte reale si ale naturii
Thiosemicarbazones are organic compounds with remarkable biological properties, including anticancer, antibiotic, antifungal, and antioxidant effects.
USM ADMIN
doaj  

Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones [PDF]

, 2018
Clinical failure of novel drugs is often related to their rapid metabolism and excretion. This highlights the importance of elucidation of their pharmacokinetic profile already at the preclinical stage of drug development.
Koellensperger, Gunda (Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna), Frensemeier, Lisa M. (Institute of Inorganic and Analytical Chemistry, University of Muenster), Kowol, Christian R. (Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna), Keppler, Bernhard K. (Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna), Pelivan, Karla (Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna), Heffeter, Petra (Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna), Karst, Uwe (Institute of Inorganic and Analytical Chemistry, University of Muenster)   +6 more
core   +1 more source

In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors

Pharmaceuticals
Background/Objectives: Four years after the COVID-19 pandemic, a very limited number of drugs has been marketed; thus, the search for new medications still represents a compelling need.
Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico   +9 more
doaj   +1 more source

Synthesis, antiviral evaluation and molecular docking studies of N4-aryl substituted/unsubstituted thiosemicarbazones derived from 1-indanones as potent anti-bovine viral diarrhea virus agents.

Bioorganic & Medicinal Chemistry, 2017
A series of N4-arylsubstituted thiosemicarbazones derived from 1-indanones and a set of compounds lacking such substitution in the N4 position of the thiosemicarbazone moiety were synthesized and evaluated for their anti-bovine viral diarrhea virus (BVDV)
M. C. Soraires Santacruz, Matías Fabiani, Eliana Castro, L. Cavallaro, L. Finkielsztein   +4 more
semanticscholar   +1 more source

Electrochemical Studies of Monoterpenic Thiosemicarbazones as Corrosion Inhibitor for Steel in 1 M HCl

, 2018
We have studied the inhibitory effect of some Monoterpenic Thiosemicarbazones on steel corrosion in 1 M HCl solution. The potentiodynamic polarization and electrochemical impedance spectroscopy were used.
R. Idouhli, A. N. Ousidi, Y. Koumya, A. Abouelfida, A. Benyaich, A. Auhmani, Moulay Youssef Ait Itto   +6 more
semanticscholar   +1 more source

Synthesis of Thiosemicarbazones of Some Aromatic Fluoro-Ketones as Potential Pesticides [PDF]

, 1963
Synthesis of Thiosemicarbazones of Some Aromatic Fluoro-Ketones as Potential ...
K. C. Joshi, S. C. Bahel
core   +1 more source