Results 61 to 70 of about 7,220 (228)

Exploring the synthesis, characterization, and corrosion inhibition of new tris-thiosemicarbazone derivatives for acidic steel settings using computational and experimental studies

Scientific Reports
A novel two tri-thiosemicarbazones derivatives, namely 2,2',2''-((2-Hydroxybenzene-1,3,5-triyl)tris(methanylylidene))tris(N-benzylhydrazine-1-carbothioamide) (HBC) and 2,2',2''-((2-hydroxybenzene-1,3,5-triyl) tris (methanylylidene)) tris (N ...
Ahmed M. Abuelela, Mahmoud A. Bedair, Ehab S. Gad, Y. F. El-Aryan, Wael Abdelgayed Ahmed Arafa, Asmaa K. Mourad, H. Nady, Salah Eid   +7 more
doaj   +1 more source

Synthesis, absorption, distribution, metabolism, excretion and antioxidant assay of some N4 –substituted thiosemicarbazones of cinnamaldehyde

One Health & Risk Management
Introduction. The increasing number of cancer diagnoses is a pressing issue in modern medicine. One contributing factor to cancer development is oxidative stress caused by free radicals, which can damage proteins, lipids, and DNA.
Andrei CIURSIN, Roman RUSNAC, Aurelian GULEA   +2 more
doaj   +1 more source

Investigation of the Biological Properties of (Hetero)Aromatic Thiosemicarbazones

Molecules, 2012
Two series of thiosemicarbazone-based iron chelators (twenty-seven compounds) were designed and synthesized using a microwave-assisted approach. Quinoline and halogenated phenyl were selected as parent scaffolds on the basis of a similarity search.
Jaroslaw Polanski, Marcela Vejsova, Alicja Ratuszna, Robert Musiol, Katarina Kralova, Matus Pesko, Josef Jampilek, Anna Mrozek-Wilczkiewicz, Maciej Serda   +8 more
doaj   +1 more source

Modulation of Transcription Profile Induced by Antiproliferative Thiosemicarbazone Metal Complexes in U937 Cancer Cells

Pharmaceutics, 2023
Since the discovery of cisplatin, the search for metal-based compounds with therapeutic potential has been a challenge for the scientific community. In this landscape, thiosemicarbazones and their metal derivatives represent a good starting point for the
Serena Montalbano, Franco Bisceglie, Giorgio Pelosi, Mirca Lazzaretti, Annamaria Buschini   +4 more
doaj   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

Synthesis, In Vitro Antitumor Activity, and In Silico ADMET Evaluation of β-Lapachone-Based Thiosemicarbazones

Drugs and Drug Candidates
Background/Objectives: β-Lapachone and triapine are compounds with recognized antitumor potential—the former is an ortho-naphthoquinone, and the latter a thiosemicarbazone inhibitor of ribonucleotide reductase. This study aimed to synthesize and evaluate
Elizabete Silva de Sousa, Edilane Almeida da Silva, Délis Galvão Guimarães, Ingrid Louise Santos de Souza, Arlan de Assis Gonsalves, Paulo Michel Pinheiro Ferreira, Rayran Walter Ramos de Sousa, Marcília Pinheiro da Costa, Cleônia Roberta Melo Araújo   +8 more
doaj   +1 more source

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

Molecules, 2013
New imidazole derived thiosemicarbazones and hydrazones were prepared by condensation of 4(5)-imidazole carboxaldehyde, 4-(1H-imidazole-1-yl)benzaldehyde and 4-(1H-imidazole-1-yl)acetophenone with a thiosemicarbazide or hydrazide.
Jacqueline A. Takahashi, Isolda C. Mendes, Camila F. Vilela, Nayane F. Silva, Jeferson G. Da Silva, Angel A. Recio Despaigne, Débora C. Reis, Heloisa Beraldo   +7 more
doaj   +1 more source

Synthesis and characterization of some new Cu(I) complexes with thiosemicarbazone ligands [PDF]

, 2012
Thiosemicarbazones (TSCs) have received significant attention due to their eventual therapeutic activities against bacterial and viral infections, tuberculosis and leprosy.
Kumari, Poonam
core  

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti‐Tumor Activity Against Ewing Sarcoma

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Caroline de Bem Gentz, Thais Helena Maciel Fernandes, Marcela Silva Lopes, Lewis Elson, Andreas Krämer, Lucas Rodrigo de Souza, Isadora Serraglio Fortes, Geórgia Silva Pinto, Martha Cestari Silva Martins, Henrique Barros de Lima, André da Silva Santiago, Lauro José Gregianin, Katlin Brauer Massirer, Mário Henrique Bengtson, Rafael Roesler, Stefan Knapp, Stefan A. Laufer, Saulo Fernandes de Andrade   +17 more
wiley   +1 more source

Structural Studies of 2,6-Diacetyl- and 2,6-Diformylpyridine Bis(thiosemicarbazones)

Journal of the Brazilian Chemical Society, 2002
Although a large number of crystal structures of heterocyclic thiosemicarbazones have recently appeared in the literature, few structures of heterocyclic bis(thiosemicarbazones) or their metal complexes have been reported.
Brown Christine A., Kaminsky Werner, Claborn Kacey A., Goldberg Karen I., West Douglas X.   +4 more
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