Results 61 to 70 of about 4,853 (201)

Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT Emetine (EMT), a naturally occurring tetrahydroisoquinoline alkaloid, shows diverse biological actions, including anticancer effects. Despite existing studies, the role of EMT derivatives in cancer, particularly in relation to the PI3K/AKT/mTOR signalling pathway, remains largely underexplored.
Mst. Ismatara Khatun, Samy Selim, Asif Hassan Malik, Md. Sakib Al Hasan, Abul Bashar Ripon Khalipha, Noshin Tasnim Yana, Mohammad Y. Alshahrani, Md. Arif Hossain, Imam Hossen Rakib, Anike Chakrabarty, Emon Mia   +10 more
wiley   +1 more source

Pyridyl‐Imidazopyridine Derivatives Displaying Submicromolar Activity Against Trypanosoma cruzi

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Previously reported pyridyl‐thiazoles and highly active imidazopyridines against Trypanosoma cruzi inspired the design of a new series of pyridyl‐substituted imidazopyridines. Among the synthesized compounds, 5h emerged as the most promising derivative, displaying potent trypanocidal activity (EC50 = 0.16 μM), excellent selectivity (SI > 1250), and ...
Ana Carolina Rocha Barreto, Kelly Lopes Figueira, Raquel Azevedo, Ketlym da Conceição, Ludmila de Ferreira de Almeida Fiuza, Luan dos Santos Vianna, Thiago Apolinário de Moraes, Wagner Alves de Souza Júdice, Maria de Nazaré Correia Soeiro, Jones Limberger   +9 more
wiley   +1 more source

Synthesis, In Vitro Antitumor Activity, and In Silico ADMET Evaluation of β-Lapachone-Based Thiosemicarbazones

Drugs and Drug Candidates
Background/Objectives: β-Lapachone and triapine are compounds with recognized antitumor potential—the former is an ortho-naphthoquinone, and the latter a thiosemicarbazone inhibitor of ribonucleotide reductase. This study aimed to synthesize and evaluate
Elizabete Silva de Sousa, Edilane Almeida da Silva, Délis Galvão Guimarães, Ingrid Louise Santos de Souza, Arlan de Assis Gonsalves, Paulo Michel Pinheiro Ferreira, Rayran Walter Ramos de Sousa, Marcília Pinheiro da Costa, Cleônia Roberta Melo Araújo   +8 more
doaj   +1 more source

Fluorinated pyrazolinic thiosemicarbazones: selective synthesis and computational analysis [PDF]

Thiosemicarbazones are a class of iminic organosulfur compounds synthesized by condensation reaction between a thiosemicarbazide and an aldehyde or ketone.
Machado, Vanessa Fernandes, Deflon, Victor Marcelo, Miranda, Victor Maia, Marques, Fabio Luiz Navarro   +3 more
core   +1 more source

Transalkylidation reaction: green, catalyst-free synthesis of thiosemicarbazones and solving the NMR conflict between their acyclic structure and intramolecular cycloaddition products

Green Chemistry Letters and Reviews, 2019
A series of arylidene thiosemicarbazides have been prepared by a new method, which was titled as transalkylidation. This method is an effective, fast, green and clean method. The mechanism of this reaction has been discussed.
Mohamed A. El-Atawy, Alaa Z. Omar, Mohamed Hagar, Essam M. Shashira   +3 more
doaj   +1 more source

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis

Molecules, 2019
Co-infection of malaria and tuberculosis, although not thoroughly investigated, has been noted. With the increasing prevalence of tuberculosis in the African region, wherein malaria is endemic, it is intuitive to suggest that the probability of co ...
Richard M. Beteck, Ronnett Seldon, Audrey Jordaan, Digby F. Warner, Heinrich C. Hoppe, Dustin Laming, Setshaba D. Khanye   +6 more
doaj   +1 more source

Silencing the Signal: The Metastasis Suppressor NDRG1 Disrupts Small Extracellular Vesicle‐Mediated Crosstalk in Pancreatic Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
NDRG1 suppresses pancreatic cancer progression by disrupting small extracellular vesicle biogenesis, altering cargo composition, and inhibiting EV uptake by cancer cells—thereby impairing tumour–stroma communication and fibrotic activation. This study reveals NDRG1 as a novel regulator of extracellular vesicle dynamics and a promising therapeutic ...
Jiawei Chang, Shafi Alenizi, Heloisa Zaccaron Milioli, Winston Lay, Saranya Pounraj, Yujie Li, Mekonnen Sisay Shiferaw, Elham Hosseini‐Beheshti, Zaklina Kovacevic   +8 more
wiley   +1 more source

Development of pyridyl thiosemicarbazones as highly potent agents for the treatment of malaria after oral administration

, 2019
Objectives: Drug resistance exists to all current and investigational antimalarial drug classes. Consequently, we have set out to develop chemically and mechanistically discrete antimalarials.
Chavchich, Marina, de Kock, Carmen, Birrell, Geoffrey W, Edstein, Michael D, Richardson, Des R, Parkinson, Christopher J, Mackenzie, Donna, Haynes, Richard K   +7 more
core   +1 more source

Synthesis, Characterization, Crystal Structures and Urease Inhibition of Thiosemicarbazones

Acta Chimica Slovenica
Thiosemicarbazones are biological active compounds. Six new thiosemicarbazones were prepared and structurally characterized by elemental analysis, 1H NMR and IR spectra, as well as single crystal X-ray diffraction.
Ling-Wei Xue, Qiao-Ru Liu, Yong-Jun Han
doaj   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, Volume 26, Issue 7, July 2026.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source