Results 21 to 30 of about 14,086 (252)

Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent and Selective Anti-Tumor Activity [PDF]

, 2023
Background: Thiosemicarbazones of the di-2-pyridylketone thiosemicarbazone class possess potent anti-tumor activity via binding essential metal ions in cancer cells (e.g., iron (Fe(II)), copper (Cu(II)), and zinc (Zn(II)) to form metal complexes.
Dharmasivam, Mahendiran, Kaya, Busra, Richardson, Des   +2 more
core   +1 more source

Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent Activity, Inhibits Heme Center Oxidation, and Results in a Novel "Stealth Zinc(II) Complex".

Journal of Medicinal Chemistry, 2023
A novel, potent, and selective antitumor agent, namely (E)-3-phenyl-1-(2-pyridinyl)-2-propen-1-one 4,4-dimethyl-3-thiosemicarbazone (PPP44mT), and its analogues were synthesized and characterized and displayed strikingly distinctive properties.
M. Dharmasivam, Buşra Kaya, Tharushi P. Wijesinghe, Mahan Gholam Azad, Miguel A Gonzálvez, Mohammad Hussaini, Jason Chekmarev, P. Bernhardt, D. Richardson   +8 more
semanticscholar   +1 more source

Pyridine-Based NNS Tridentate Chitosan Thiosemicarbazones and Their Copper(II) Complexes: Synthesis, Characterization, and Anticancer Activity

ACS Omega, 2022
Chitosan-functionalized pyridine-based thiosemicarbazones and their copper(II) complexes have been found to own a substantial antiproliferative activity against the tumorigenic Madin Darby canine kidney (MDCK) and MCF-7 cancer cell lines.
Hari Sharan Adhikari, Aditya Garai, K. Manandhar, P. Yadav   +3 more
semanticscholar   +1 more source

Thiosemicarbazones as versatile photoswitches with light-controllable supramolecular activity. [PDF]

Chem Sci
Using photoswitchable molecules to manipulate supramolecular interactions under light illumination has driven advancements in numerous fields, allowing for the strategic alteration of molecular systems.
Sentürk B, Butschke B, Eisenreich F.
europepmc   +3 more sources

Rhodium Assisted C−H Activation of Benzaldehyde Thiosemicarbazones and Their Oxidation via Activation of Molecular Oxygen [PDF]

, 2016
The benzaldehyde thiosemicarbazones are found to undergo oxidation at the sulfur center upon reaction with [Rh(PPh3)3Cl] in refluxing ethanol in the presence of a base (NEt3).
Shie-Ming Peng (1425703), Gene-Hsiang Lee (1470748), Swati Dutta (2652208), Larry R. Falvello (546330), Falguni Basuli (2361007), Rama Acharyya (2327668), Samaresh Bhattacharya (2463109)   +6 more
core   +9 more sources

Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series [PDF]

, 2023
The di-2-pyridylketone thiosemicarbazones demonstrated marked anticancer efficacy, prompting progression of DpC to clinical trials. However, DpC induced deleterious oxy-myoglobin oxidation, stifling development.
Bernhardt, Paul V, Gholam Azad, Mahan, Richardson, Des R., Wijesinghe, Tharushi P, Bernhardt, Paul V., Gonzálvez, Miguel A, Wijesinghe, Tharushi P., Harmer, Jeffrey R, Gonzalvez, Miguel A., Kaya, Busra, Dharmasivam, Mahendiran, Richardson, Des R, Harmer, Jeffrey R.   +12 more
core   +1 more source

Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms [PDF]

, 2020
Combining low-dose chemotherapies is a strategy for designing less toxic and more potent childhood cancer treatments. We examined the effects of combining the novel thiosemicarbazones, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC ...
Jakub Neradil, Erika Mikulenkova, Chlapek, Petr, Jaroslav Sterba, Renata Veselska, Silvia Paukovcekova, Jan Skoda, Des R. Richardson, Petr Chlapek, Skoda, Jan, Sterba, Jaroslav, Neradil, Jakub, Paukovcekova, Silvia, Richardson, Des R, Veselska, Renata, Mikulenkova, Erika   +15 more
core   +1 more source

SYNTHESIS, CHARACTERIZATION AND THERMAL STUDIES OF MIXED LIGAND COMPLEXES OF Hg(II) THIOSEMICARBAZONES WITH 2-AMINOTHIAZOLE [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2009
Several Hg(II) mixed ligand complexes of thiosemicarbazones (2-acetylpyridine-, 4-aminoacetophenone- and 2-furaldehyde thiosemicarbazones) with 2-aminothiazole have beenprepared.
Kamal Al-Jadabi
doaj   +1 more source

Monosubstituted Acetophenone Thiosemicarbazones as Potent Inhibitors of Tyrosinase: Synthesis, Inhibitory Studies, and Molecular Docking

Pharmaceuticals, 2021
A set of 12 monosubstituted acetophenone thiosemicarbazone derivatives (TSCs) were synthesized and their inhibitory properties toward tyrosinase activity were tested.
Katarzyna Hałdys, Waldemar Goldeman, Natalia Anger-Góra, Joanna Rossowska, Rafał Latajka   +4 more
doaj   +1 more source

Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core [PDF]

, 2014
A series of novel hexa-arm star shaped thiosemicarbazones with different substitutions at para positions emanating from cyclotriphosphazene core were prepared with excellent yields.
Patil, B.R., Machakanur, S.S., Bakale, R.P., Naik, G.N., Bligh, S.W.A., Gudasi, K.B.   +5 more
core   +1 more source