Results 21 to 30 of about 4,853 (201)

Thiosemicarbazones as versatile photoswitches with light-controllable supramolecular activity. [PDF]

Chem Sci
Using photoswitchable molecules to manipulate supramolecular interactions under light illumination has driven advancements in numerous fields, allowing for the strategic alteration of molecular systems.
Sentürk B, Butschke B, Eisenreich F.
europepmc   +2 more sources

Designing Tailored Thiosemicarbazones with Bespoke Properties: The Styrene Moiety Imparts Potent and Selective Anti-Tumor Activity

, 2023
Background: Thiosemicarbazones of the di-2-pyridylketone thiosemicarbazone class possess potent anti-tumor activity via binding essential metal ions in cancer cells (e.g., iron (Fe(II)), copper (Cu(II)), and zinc (Zn(II)) to form metal complexes.
Dharmasivam, Mahendiran, Kaya, Busra, Richardson, Des   +2 more
core   +1 more source

A Review On Organotin(Iv) Thiosemicarbazone Complexes, Synthesis, Characterization And Biological Activity [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2021
Organotin(IV) complexes recently have been receiving great attention due to their stability with a unique structure, physical and chemical properties. There are many applications, the organotin(IV) can be used as catalysts, antifouling agents, UV- and ...
Rawnaq B. Jimaa, Jinan Mohammed Mahmood Al-Zinkee   +1 more
doaj   +1 more source

Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity

Molecules, 2005
Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described.
Cavit Kazaz, Alaaddin Çukurovali, Misir Ahmedzade, Murat Koca   +3 more
doaj   +1 more source

Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells

Frontiers in Pharmacology, 2022
Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. The present study analyzed the effects of three inhibitors, sunitinib, gefitinib, and lapatinib, combined with iron ...
Maria Krchniakova, Maria Krchniakova, Silvia Paukovcekova, Petr Chlapek, Petr Chlapek, Jakub Neradil, Jakub Neradil, Jan Skoda, Jan Skoda, Renata Veselska, Renata Veselska   +10 more
doaj   +1 more source

Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms

, 2020
Combining low-dose chemotherapies is a strategy for designing less toxic and more potent childhood cancer treatments. We examined the effects of combining the novel thiosemicarbazones, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC ...
Jakub Neradil, Erika Mikulenkova, Chlapek, Petr, Jaroslav Sterba, Renata Veselska, Silvia Paukovcekova, Jan Skoda, Des R. Richardson, Petr Chlapek, Skoda, Jan, Sterba, Jaroslav, Neradil, Jakub, Paukovcekova, Silvia, Richardson, Des R, Veselska, Renata, Mikulenkova, Erika   +15 more
core   +1 more source

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

Biomolecules, 2020
A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H2LR]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HLR)Cl]Cl (1–4) were synthesised with the aim to study (i) their ...
Miljan N. M. Milunović, Oleg Palamarciuc, Angela Sirbu, Sergiu Shova, Dan Dumitrescu, Dana Dvoranová, Peter Rapta, Tatsiana V. Petrasheuskaya, Eva A. Enyedy, Gabriella Spengler, Marija Ilic, Harald H. Sitte, Gert Lubec, Vladimir B. Arion   +13 more
doaj   +1 more source

A Tale of Two Mechanisms: The p53 Modulator COTI-2 Is a Zn Metallochaperone. [PDF]

Drug Dev Res
ABSTRACT Mutations in, or misregulation of, Tp53 are found in approximately 50% of all cancers. p53 functions by ensuring that cells with irretrievably damaged DNA undergo apoptosis. Tp53 mutations often induce conformational changes that inhibit activity; however, small‐molecule chaperones could theoretically restore conformation and activity. COTI‐2,
Şimşek İ, Shahbazi-Raz F, Krause MJ, Mohammadzadeh A, Kosar M, Xu P, Khan S, Tykhoniuk O, DaDalt A, Almasri D, Watanabe LK, Breault K, Hayward JJ, Pick FS, Ho RL, Rawson JM, Trant JF.   +16 more
europepmc   +2 more sources

Thiosemicarbazones active against Clostridium difficile [PDF]

, 2008
A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against
Parker, Katy J., Rathbone, Daniel L., Worthington, Tony, Wheeldon, Laura, Costello, Cait, Lambert, Peter A., Karpanen, Tarja, Ren, Jiangmeng, Mistry, Preena   +8 more
core   +1 more source

Rhodium Assisted C−H Activation of Benzaldehyde Thiosemicarbazones and Their Oxidation via Activation of Molecular Oxygen

, 2016
The benzaldehyde thiosemicarbazones are found to undergo oxidation at the sulfur center upon reaction with [Rh(PPh3)3Cl] in refluxing ethanol in the presence of a base (NEt3).
Shie-Ming Peng (1425703), Gene-Hsiang Lee (1470748), Swati Dutta (2652208), Larry R. Falvello (546330), Falguni Basuli (2361007), Rama Acharyya (2327668), Samaresh Bhattacharya (2463109)   +6 more
core   +5 more sources