Results 11 to 20 of about 2,427 (174)

Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones. [PDF]

Chem Biodivers
The synthesis of new thiosemicarbazones bearing Schiff base was performed. The structures of the compounds were characterized through several spectroscopic methods. The antioxidant potential of these compounds was evaluated through DPPH• in vitro assays. In addition, their inhibitory activities against urease and xanthine oxidase (XO) were investigated.
Yakan H, Muglu H, Yenigun S, Ozen T.
europepmc   +2 more sources

Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling. [PDF]

ChemMedChem
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Silva AJFSD, Olimpio DSDC, Sousa LMDS, Brondani GL, Silva TL, Silva WBL, Costa NTC, Hernandes MZ, Junior PAS, Pereira VRA, Leite ACL.   +10 more
europepmc   +2 more sources

A Review On Organotin(Iv) Thiosemicarbazone Complexes, Synthesis, Characterization And Biological Activity [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2021
Organotin(IV) complexes recently have been receiving great attention due to their stability with a unique structure, physical and chemical properties. There are many applications, the organotin(IV) can be used as catalysts, antifouling agents, UV- and ...
Rawnaq B. Jimaa, Jinan Mohammed Mahmood Al-Zinkee   +1 more
doaj   +1 more source

Palladium(II) Complexes of NS Donor Ligands Derived from Steroidal Thiosemicarbazones as Antibacterial Agents

Molecules, 2010
We have investigated the antibacterial activity of some new steroidal thiosemicarbazones and their Pd(II) metal complexes were prepared by the reaction of the thiosemicarbazones with [Pd(DMSO)2Cl2].
Abdullah M. Asiri, Salman A. Khan
doaj   +1 more source

Synthesis, Cytotoxic Activity, mRNA Expression, Total Oxidant and Antioxidant Status, and Molecular Modeling Studies of Novel Schiff Base-Thiosemicarbazone Hybrids. [PDF]

J Biochem Mol Toxicol
In this study, new Schiff base‐derived compounds were synthesized, and their structures were confirmed by FT‐IR, 1H‐NMR, 13C‐NMR, and HRMS analyses. The cytotoxic effects of the compounds on a prostate cancer cell line (PC3) were investigated, and it was determined that the compounds NZ10, NZ9, NZ7, and NZ4, in particular, exhibited potent anticancer ...
Anber AM, Özbay M, İlhan İÖ, Kekeçmuhammed H, Bora RE, Saripinar E, Erzurumlu Y, Muhammed MT, Alhag SK, Alkeridis LA, Akkoc S.   +10 more
europepmc   +2 more sources

Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity

Molecules, 2005
Preparation in excellent yields of cyclobutyl benzofuran-2-yl- and naphthofuran- 2-yl-ketones, the corresponding ketoximes and thiosemicarbazones, ether derivatives of the ketoximes and thiazoles derived from the thiosemicarbazones are described.
Cavit Kazaz, Alaaddin Çukurovali, Misir Ahmedzade, Murat Koca   +3 more
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Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells

Frontiers in Pharmacology, 2022
Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. The present study analyzed the effects of three inhibitors, sunitinib, gefitinib, and lapatinib, combined with iron ...
Maria Krchniakova, Maria Krchniakova, Silvia Paukovcekova, Petr Chlapek, Petr Chlapek, Jakub Neradil, Jakub Neradil, Jan Skoda, Jan Skoda, Renata Veselska, Renata Veselska   +10 more
doaj   +1 more source

Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

Ciência e Agrotecnologia, 2014
Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A.
Rojane de Oliveira Paiva, Lucimar Ferreira Kneipp, Carla Marins Goular, Mariana Almeida Albuquerque, Aurea Echevarria   +4 more
doaj   +1 more source

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

Biomolecules, 2020
A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H2LR]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HLR)Cl]Cl (1–4) were synthesised with the aim to study (i) their ...
Miljan N. M. Milunović, Oleg Palamarciuc, Angela Sirbu, Sergiu Shova, Dan Dumitrescu, Dana Dvoranová, Peter Rapta, Tatsiana V. Petrasheuskaya, Eva A. Enyedy, Gabriella Spengler, Marija Ilic, Harald H. Sitte, Gert Lubec, Vladimir B. Arion   +13 more
doaj   +1 more source

A Thiosemicarbazone Schiff Base and Its Titanium(IV) Complexes: Spectral Analysis, DFT Studies, and Biological Evaluation. [PDF]

Chem Biodivers
DFT computations are used to analyze the electronic structure, stability, and reactivity profiles of a new Schiff base ligand and its Ti(IV) complexes and are characterized by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectrometry and screened for antimicrobial activities against E. coli, S. aureus, ESBL, MRSA, Mtb, A.
Ghanghas P, Yadav A, Kamboj A, Choudhary A, Kour M, Kumar D, Poonia K.   +6 more
europepmc   +2 more sources