Results 11 to 20 of about 9,384 (213)

Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines [PDF]

Bioinorganic Chemistry and Applications, 2013
The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2′-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3′-hydroxy ...
Wilfredo Hernández, Juan Paz, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Lothar Hennig, Joachim Sieler, Steffen Blaurock, Lothar Beyer   +9 more
doaj   +4 more sources

Benzaldehyde thiosemicarbazone

Acta Crystallographica Section E, 2008
The title compound, C8H9N3S, contains two molecules in the asymmetric unit. One molecule is close to being planar (r.m.s. deviation from the mean plane = 0.06 Å for the non-H atoms), while the other exhibits a dihedral angle of 21.7 (1)&#
Xiu-Ping Ju, Ji-Dong Zhang, Yan Qiao, Lingqian Kong   +3 more
doaj   +2 more sources

Preparation, Spectroscopic Elucidation, Antioxidant Potential, Enzyme Inhibition, and Molecular Docking Studies of Novel Schiff Base-Derived Thiosemicarbazones. [PDF]

Chem Biodivers
The synthesis of new thiosemicarbazones bearing Schiff base was performed. The structures of the compounds were characterized through several spectroscopic methods. The antioxidant potential of these compounds was evaluated through DPPH• in vitro assays. In addition, their inhibitory activities against urease and xanthine oxidase (XO) were investigated.
Yakan H, Muglu H, Yenigun S, Ozen T.
europepmc   +2 more sources

A Thiosemicarbazone Schiff Base and Its Titanium(IV) Complexes: Spectral Analysis, DFT Studies, and Biological Evaluation. [PDF]

Chem Biodivers
DFT computations are used to analyze the electronic structure, stability, and reactivity profiles of a new Schiff base ligand and its Ti(IV) complexes and are characterized by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectrometry and screened for antimicrobial activities against E. coli, S. aureus, ESBL, MRSA, Mtb, A.
Ghanghas P, Yadav A, Kamboj A, Choudhary A, Kour M, Kumar D, Poonia K.   +6 more
europepmc   +2 more sources

Synthetic Strategy to Novel Highly Functionalized Furan Analogues Bearing Imidazole-Thiazole Hybrids: Structural Characterization, Nanoparticle Formulations, Antimicrobial Evaluation, Molecular Docking Studies, and Molecular Dynamic Simulations. [PDF]

Chem Biodivers
A novel highly functionalized furan analogues bearing imidazole–thiazole hybrids were prepared via efficient synthetic routes. Selected compounds were formulated into nanoparticle systems. Antimicrobial evaluation for all synthesized compounds and nanoformulations was evaluated against a panel of bacterial strains.
Sediek AA, Kamel AA, El-Borady OM, El-Sayed AF, El-Rashedy AA, Sabry E.   +5 more
europepmc   +2 more sources

Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling. [PDF]

ChemMedChem
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Silva AJFSD, Olimpio DSDC, Sousa LMDS, Brondani GL, Silva TL, Silva WBL, Costa NTC, Hernandes MZ, Junior PAS, Pereira VRA, Leite ACL.   +10 more
europepmc   +2 more sources

Diethylene Glycol-Linked Ring-Fused Bis-Azoles: Target-Oriented Synthesis, In Silico Screening, and Antitumor Activity. [PDF]

ChemMedChem
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Al-Hussain SA, Alharbi AS, Muhammad ZA, Halim ASA, Zaki MEA, Bagley MC, Kassab RM.   +6 more
europepmc   +2 more sources

Hematite (α‐Fe2O3) Nanoparticles Conjugated with Thiosemicarbazones: Hydrothermal‐Assisted Synthesis, Characterization, Antibacterial, Antioxidant, and Photocatalytic Activities [PDF]

Chem Biodivers
The study describes the functionalization of α‐Fe2O3 nanoparticles with three different thiosemicarbazone ligands through a hydrothermal route. The nanoconjugates were tested for their antibacterial and antioxidant activities, and their photocatalytic potential was tested against malachite green dye.
Veg E, Dwivedi S, Rai S, Sharma S, Fatima N, Joshi S, Khan A, Khan T.   +7 more
europepmc   +2 more sources

Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes [PDF]

, 2016
The oxidation of human oxyhemoglobin (HbO) to methemoglobin (metHb) is an undesirable side effect identified in some promising thiosemicarbazone anti-cancer drugs.
Basha, Maram T, Bordini, Jeane, Bernhardt, Paul V, Richardson, Des R., Bernhardt, Paul V., Richardson, Des R, Basha, Maram T., Martinez, Manuel   +7 more
core   +1 more source

Synthesis, Spectroscopic Characterization, Structural Studies, and In Vitro Antitumor Activities of Pyridine-3-carbaldehyde Thiosemicarbazone Derivatives

Journal of Chemistry, 2020
Eight new thiosemicarbazone derivatives, 6-(1-trifluoroethoxy)pyridine-3-carbaldehyde thiosemicarbazone (1), 6-(4′-fluorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (2), 5-chloro-pyridine-3-carbaldehyde thiosemicarbazone (3), 2-chloro-5-bromo ...
Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Maik Icker, Harald Krautscheid, Lothar Beyer   +7 more
doaj   +1 more source