Results 11 to 20 of about 12,825 (226)

From Design to Bioactivity: 2‐Benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone and Its 3d Metal Coordination Compounds

ChemistryOpen
The new 2‐benzoylpyridine 4‐(bicyclo[2.2.1]hept‐2‐yl)thiosemicarbazone (HL) and its copper(II), nickel(II), cobalt(III), and iron(III) coordination compounds [Cu(L)Cl] (1), [Cu(L)NO3] (2), {[Cu(L)(Cl2CHCOO)]}n (3), [Ni(HL)2](NO3)2 (4), [Fe(L)2]NO3 (5 ...
Ianina Graur, Vasilii Graur, Elena Melnic, Carolina Lozan‐Tirsu, Greta Balan, Victor Tsapkov, Aurelian Gulea   +6 more
doaj   +2 more sources

Synthesis, Characterization, Biological Properties, and Sensor Applications of Novel Thiosemicarbazone Derivatives. [PDF]

Biotechnol Appl Biochem
ABSTRACT In this study, novel thiosemicarbazone derivative molecules (5a–j) were synthesized. The characterization of the synthesized molecules was carried out using 1H–, 13C–NMR, FT–IR, and Q–TOF spectroscopic techniques. Then, the inhibitory effect of these compounds was examined for human carbonic anhydrase I and II (hCA I, and II) and ...
Gezegen H, Özbek O, Topal M, Şahin H, Koçyiğit ÜM.   +4 more
europepmc   +2 more sources

Evaluation of a New Methylimidazole-Containing Thiosemicarbazone as a Cu⁺/Cu²⁺-Targeting Ligand in the Context of Alzheimer's Disease. [PDF]

Chemistry
HXE modulates Cu(Aβ) interaction, reducing ROS production and shifting peptide aggregation in the presence of Cu from toxic amorphous aggregates to less harmful fibrillar structures. These findings highlight HXE potential to interfere with Cu‐induced oxidative stress and aggregation pathways relevant to AD.
Marinho Barbosa B, Esmieu C, Galvácsi A, Costa MV, Brison A, Ladeira SM, de Oliveira J, Kállay C, Hureau C, Rey NA.   +9 more
europepmc   +2 more sources

Quantum Chemical Studies on the Corrosion Inhibition of Fe78B13Si9 glassy alloy in Na2SO4 Solution of Some Thiosemicarbazone Derivatives

International Journal of Electrochemical Science, 2018
In this study, the density functional theory (DFT) at the gradient-corrected correlation functional of Lee-Yang-Parr (B3LYP) functional with 6-311++G(2d,2p), correlation-consistent, polarized valence, X-zeta (cc-pVTZ) basis sets, BP86 functional with/6 ...
Murat Saraçoğlu, Mahmooud Ibrahim A. Elusta, Savaş Kaya, Cemal Kaya, Fatma Kandemirli   +4 more
doaj   +1 more source

An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study

Journal of Analytical Science and Technology, 2020
Background Bromophenol-thiosemicarbazone hybrid was a novel synthetic brominated anticancer compound with two bromine atoms. Bromophenol-thiosemicarbazone hybrid showed considerable selective inhibitory activity against PARP1 (IC50 = 29.5 nmol/L).
Xiuxue Li, Lijun Wang, Xiaoling Jia, Chuanlong Guo, Chao Li, Jiajia Zhang, Dayong Shi   +6 more
doaj   +1 more source

Half-Sandwich Arene Ruthenium(II) Thiosemicarbazone Complexes: Evaluation of Anticancer Effect on Primary and Metastatic Ovarian Cancer Cell Lines

Frontiers in Pharmacology, 2022
In this study, we describe the synthesis, characterization and antiproliferative activity of three organo-ruthenium(II) half-sandwich complexes [RuCl(η6-p-cym)(N,S-L)]Cl (I, II, and III).
Seminay Guler, Seminay Guler, Hulya Ayar Kayali, Hulya Ayar Kayali, Hulya Ayar Kayali, Egemen Orkun Sadan, Betul Sen, Elif Subasi   +7 more
doaj   +1 more source

New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma. [PDF]

Arch Pharm (Weinheim)
Focusing on the discovery of new therapeutics for childhood cancer, novel quinoline derivatives were synthesized and demonstrated activity against Ewing sarcoma. A target search was performed against a panel of kinases, and the compounds showed selectivity for the NAK family, mainly GAK, which was confirmed by enzyme kinetic assays.
Gentz CB, Fernandes THM, Lopes MS, Elson L, Krämer A, Souza LR, Fortes IS, Pinto GS, Martins MCS, Lima HB, Santiago ADS, Gregianin LJ, Massirer KB, Bengtson MH, Roesler R, Knapp S, Laufer SA, Andrade SF.   +17 more
europepmc   +2 more sources

Synthesis, Spectroscopic Characterization, Structural Studies, and In Vitro Antitumor Activities of Pyridine-3-carbaldehyde Thiosemicarbazone Derivatives

Journal of Chemistry, 2020
Eight new thiosemicarbazone derivatives, 6-(1-trifluoroethoxy)pyridine-3-carbaldehyde thiosemicarbazone (1), 6-(4′-fluorophenyl)pyridine-3-carbaldehyde thiosemicarbazone (2), 5-chloro-pyridine-3-carbaldehyde thiosemicarbazone (3), 2-chloro-5-bromo ...
Wilfredo Hernández, Fernando Carrasco, Abraham Vaisberg, Evgenia Spodine, Jorge Manzur, Maik Icker, Harald Krautscheid, Lothar Beyer   +7 more
doaj   +1 more source

From actually toxic to highly specific – novel drugs against poxviruses [PDF]

, 2007
The potential use of variola virus, the causative agent of smallpox, as a bioweapon and the endemic presence of monkeypox virus in Africa demonstrate the need for better therapies for orthopoxvirus infections. Chemotherapeutic approaches to control viral
Sliva, Katja, Schnierle, Barbara
core   +2 more sources

α-N-heterocyclic thiosemicarbazone derivatives as potential antitumor agents: A structure-activity relationships approach [PDF]

, 2009
α-N-Heterocyclic thiosemicarbazones, (N)-TSCs, are potent inhibitors of ribonucleotide reductase (RR). This enzyme plays a critical role in DNA synthesis and repair, and is a well-recognized target for cancer chemotherapeutic agents.
Matesanz, Ana I., Souza, Pilar
core   +2 more sources