Results 11 to 20 of about 3,211 (192)

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284. [PDF]

FEBS Lett
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Di Napoli G, Fissore A, Salladini E, Raccuia E, Oliaro-Bosso S, Ruggiero A, Berisio R, Medina M, Velazquez-Campoy A, Adinolfi S, Marengo M.   +10 more
europepmc   +4 more sources

Thiosulfate-cyanide sulfurtransferase a mitochondrial essential enzyme: from cell metabolism to the biotechnological applications [PDF]

International Journal of Molecular Sciences, 2022
Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such
Arciero I., Buonvino S., Melino S.
core   +5 more sources

Unraveling the role of 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide in triple-negative breast cancer chemoresistance [PDF]

Frontiers in Pharmacology
BackgroundTriple-negative breast cancer (TNBC) frequently develops resistance to chemotherapy. Cancer-supporting roles of the endogenous gaseous mediator hydrogen sulfide (H2S) have been identified.
Sousanna Hakim, Danira A. Habashy, Kelly Ascenção, Rana A. Youness, Rana A. Youness, Carole Bourquin, Carole Bourquin, Csaba Szabo, Mohamed Z. Gad, Reham M. Abdelkader   +9 more
doaj   +2 more sources

Cyanide overproduction impairs cellular bioenergetics in Down syndrome [PDF]

Neurotherapeutics
Cyanide exerts its toxic effects primarily by inhibiting mitochondrial Complex IV (Cytochrome c oxidase, CCOx). Recent studies have shown that mammalian cells can endogenously produce cyanide from glycine via a lysosomal pathway.
Maria Petrosino, Karim Zuhra, Anna Kieronska-Rudek, Lucia Janickova, Olivier Bremer, Moustafa Khalaf, Brian A. Logue, Csaba Szabo   +7 more
doaj   +2 more sources

Structural and functional characterization of sulfurtransferase from Frondihabitans sp. PAMC28461. [PDF]

PLoS ONE
Sulfurtransferases transfer of sulfur atoms from thiols to acceptors like cyanide. They are categorized as thiosulfate sulfurtransferases (TSTs) and 3-mercaptopyruvate sulfurtransferases (MSTs). TSTs transfer sulfur from thiosulfate to cyanide, producing
Hackwon Do, Dieu Linh Nguyen, Yong-Yoon Ahn, Yewon Nam, YoonJi Kang, HoeJung Oh, Jisub Hwang, Se Jong Han, Kitae Kim, Jun Hyuck Lee   +9 more
doaj   +2 more sources

Functional potential of archaeal KEGG enzymes in the Moringa oleifera rhizosphere revealed by metagenomic analysis [PDF]

BMC Genomics
Background Archaea are a major domain of life that inhabit diverse and often extreme environments, contributing to biogeochemical cycles and participating in nutrient cycling within plant rhizospheric soils.
Lina Baz
doaj   +2 more sources

Acidity of persulfides and its modulation by the protein environments in sulfide quinone oxidoreductase and thiosulfate sulfurtransferase. [PDF]

J Biol Chem
Persulfides (RSSH/RSS-) participate in sulfur metabolism and are proposed to transduce hydrogen sulfide (H2S) signaling. Their biochemical properties are poorly understood. Herein, we studied the acidity and nucleophilicity of several low molecular weight persulfides using the alkylating agent, monobromobimane.
Benchoam D, Cuevasanta E, Roman JV, Banerjee R, Alvarez B.   +4 more
europepmc   +3 more sources

Discovery of a small molecule allosteric activator of human thiosulfate sulfurtransferase [PDF]

, 2023
Recent studies showed that thiosulfate sulfurtransferase (TST) is one of the few peripherally expressed genes that has been identified as a genetic risk factor for metabolic health, with clear evidence of a negative correlation with the development of ...
Al Dahmani-Al Zakwani, Zayana
core   +2 more sources

Systemic intracellular analysis for balancing complex biosynthesis in a transcriptionally deregulated Escherichia coli l‐Methionine producer

Microbial Biotechnology
l‐Methionine (l‐Met) has gained remarkable interest due to its multifaceted and versatile applications in the fields of nutrition, pharmaceuticals and clinical practice.
Claudia Harting, Attila Teleki, Marius Braakmann, Frank Jankowitsch, Ralf Takors   +4 more
doaj   +2 more sources

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes [PDF]

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +2 more sources