Results 31 to 40 of about 1,823 (144)

H₂S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

Biomolecules, 2020
We have been studying the general aspects of the functions of H2S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years.
Noriyuki Nagahara, Maria Wróbel
doaj   +1 more source

Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids

Antioxidants, 2022
Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells.
Kelly Ascenção, Nahzli Dilek, Karim Zuhra, Katalin Módis, Toshiro Sato, Csaba Szabo   +5 more
doaj   +1 more source

Promoter hypomethylation and overexpression of TSTD1 mediate poor treatment response in breast cancer

Frontiers in Oncology, 2022
Epigenetic alterations play a pivotal role in cancer treatment outcomes. Using the methylation array data and The Cancer Genome Atlas (TCGA) dataset, we observed the hypomethylation and upregulation of thiosulfate sulfurtransferase–like domain containing
Muhamad Ansar, Le Thi Anh Thu, Le Thi Anh Thu, Chin-Sheng Hung, Chin-Sheng Hung, Chin-Sheng Hung, Chih-Ming Su, Chih-Ming Su, Man-Hsu Huang, Li-Min Liao, Yu-Mei Chung, Ruo-Kai Lin, Ruo-Kai Lin, Ruo-Kai Lin, Ruo-Kai Lin   +14 more
doaj   +1 more source

Identification and characterization of single‐domain thiosulfate sulfurtransferases from Arabidopsis thaliana [PDF]

FEBS Letters, 2002
Sulfurtransferases/rhodaneses (ST) are a group of enzymes widely distributed in all three phyla that catalyze the transfer of sulfur from a donor to a thiophilic acceptor substrate. All ST contain distinct structural domains, and can exist as single‐domain proteins, as tandemly repeated modules in which the C‐terminal domain bears the active site, or ...
Bauer, Michael, Papenbrock, Jutta
openaire   +2 more sources

Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease

Redox Biology, 2023
Hydrogen sulfide (H2S) was previously revealed to inhibit osteoblastic differentiation of valvular interstitial cells (VICs), a pathological feature in calcific aortic valve disease (CAVD).
Zsolt Combi, László Potor, Péter Nagy, Katalin Éva Sikura, Tamás Ditrói, Eszter Petra Jurányi, Klaudia Galambos, Tamás Szerafin, Péter Gergely, Matthew Whiteman, Roberta Torregrossa, Yuchao Ding, Lívia Beke, Zoltán Hendrik, Gábor Méhes, György Balla, József Balla   +16 more
doaj   +1 more source

Feeding low or pharmacological concentrations of zinc oxide changes the hepatic proteome profiles in weaned piglets. [PDF]

PLoS ONE, 2013
Pharmacological levels of zinc oxide can promote growth and health of weaning piglets, but the underlying molecular mechanisms are yet not fully understood.
Angelika Bondzio, Robert Pieper, Christoph Gabler, Christoph Weise, Petra Schulze, Juergen Zentek, Ralf Einspanier   +6 more
doaj   +1 more source

Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications

International Journal of Molecular Sciences, 2022
Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms ...
Buonvino S., Arciero I., Melino S.
openaire   +4 more sources

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

EMBO Molecular Medicine, 2016
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (
Marta Luna‐Sánchez, Agustín Hidalgo‐Gutiérrez, Tatjana M Hildebrandt, Julio Chaves‐Serrano, Eliana Barriocanal‐Casado, Ángela Santos‐Fandila, Miguel Romero, Ramy KA Sayed, Juan Duarte, Holger Prokisch, Markus Schuelke, Felix Distelmaier, Germaine Escames, Darío Acuña‐Castroviejo, Luis C López   +14 more
doaj   +1 more source

H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression

Frontiers in Pharmacology, 2020
ObjectiveExcess of fructose consumption is related to life-treating conditions that affected more than a third of the global population. Therefore, to identify a newer therapeutic strategy for the impact prevention of high fructose injury in age-related ...
Yaroslav Pavlovskiy, Antonina Yashchenko, Oksana Zayachkivska   +2 more
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HYDROGEN SULFIDE-RELEASING ANTI-INFLAMMATORY DRUG ATB-340 TREATMENT POTENTIALLY REDUCES MESENTERIC METAFLAMMATION IN THE EXPERIMENTAL AGE- AND HIGH FRUCTOSE DIETARY-INDUCED INJURY

Праці Наукового товариства імені Шевченка. Медичні науки, 2021
Metaflammation (MF) is associated with visceral adiposities involved in the metabolic, cardiovascular, and gastrointestinal disease pathogenesis while their target therapeutic strategy is still limited.
Oleg Revenko, Vasyl Kovalyshyn, Antonina Yashchenko, John Wallace, Oksana Zayachkivska   +4 more
doaj   +1 more source