Results 31 to 40 of about 9,662 (145)

H₂S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

Biomolecules, 2020
We have been studying the general aspects of the functions of H2S and polysulfides, and the enzymes involved in their biosynthesis, for more than 20 years.
Noriyuki Nagahara, Maria Wróbel
doaj   +1 more source

The crystal structure of Leishmania major 3-mercaptopyruvate sulfurtransferase : A three-domain architecture with a serine protease-like triad at the active site

, 2003
Leishmania major 3-mercaptopyruvate sulfurtransferase is a crescent-shaped molecule comprising three domains. The N-terminal and central domains are similar to the thiosulfate sulfurtransferase rhodanese and create the active site containing a ...
Williams, Roderick, Coombs, GH, Mottram, JC, Williams, RAM, Mottram, Jeremy, Alphey, MS, Coombs, Graham, Hunter, William N., Alphey, Magnus S., Hunter, WN   +9 more
core   +3 more sources

Promoter hypomethylation and overexpression of TSTD1 mediate poor treatment response in breast cancer

Frontiers in Oncology, 2022
Epigenetic alterations play a pivotal role in cancer treatment outcomes. Using the methylation array data and The Cancer Genome Atlas (TCGA) dataset, we observed the hypomethylation and upregulation of thiosulfate sulfurtransferase–like domain containing
Muhamad Ansar, Le Thi Anh Thu, Le Thi Anh Thu, Chin-Sheng Hung, Chin-Sheng Hung, Chin-Sheng Hung, Chih-Ming Su, Chih-Ming Su, Man-Hsu Huang, Li-Min Liao, Yu-Mei Chung, Ruo-Kai Lin, Ruo-Kai Lin, Ruo-Kai Lin, Ruo-Kai Lin   +14 more
doaj   +1 more source

Hydrogen sulfide as an anti-calcification stratagem in human aortic valve: Altered biogenesis and mitochondrial metabolism of H2S lead to H2S deficiency in calcific aortic valve disease

Redox Biology, 2023
Hydrogen sulfide (H2S) was previously revealed to inhibit osteoblastic differentiation of valvular interstitial cells (VICs), a pathological feature in calcific aortic valve disease (CAVD).
Zsolt Combi, László Potor, Péter Nagy, Katalin Éva Sikura, Tamás Ditrói, Eszter Petra Jurányi, Klaudia Galambos, Tamás Szerafin, Péter Gergely, Matthew Whiteman, Roberta Torregrossa, Yuchao Ding, Lívia Beke, Zoltán Hendrik, Gábor Méhes, György Balla, József Balla   +16 more
doaj   +1 more source

Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients

, 2010
To test the hypothesis that impaired expression of the thiosulfate sulfurtransferase rhodanese is associated with oxidative stress and may predict mortality in hemodialysis ...
Scholze, Alexandra; id_orcid, Koch, Kathrin, Krueger, Katharina, Tepel, Martin; id_orcid, Jühling, Anja, Martin Tepel, Katharina Krueger, Alexandra Scholze, Anja Jühling, Kathrin Koch   +9 more
core   +1 more source

Structural and biochemical characterization of an encapsulin-associated rhodanese from Acinetobacter baumannii. [PDF]

Protein Sci
Abstract Rhodanese‐like domains (RLDs) represent a widespread protein family canonically involved in sulfur transfer reactions between diverse donor and acceptor molecules. RLDs mediate these transsulfuration reactions via a transient persulfide intermediate, created by modifying a conserved cysteine residue in their active sites.
Benisch R, Giessen TW.
europepmc   +2 more sources

Kinetic parameters of the thiosulfate∶cyanide sulfurtransferase activity of purified MoeBR and MoeZR.

, 2013
aThe Thiosulfate∶cyanide sulfurtransferase activity of MBP-MoeZR and MBP-MoeBR were measured by the colorimetric assay after Sörbo [21]. KM and kcat values were determined by varying concentrations of sodium thiosulfate (0.5–60 mM) and potassium cyanide (
Martin Voss (242104), Manfred Nimtz (189392), Silke Leimkühler (126058)   +2 more
core   +1 more source

Feeding low or pharmacological concentrations of zinc oxide changes the hepatic proteome profiles in weaned piglets. [PDF]

PLoS ONE, 2013
Pharmacological levels of zinc oxide can promote growth and health of weaning piglets, but the underlying molecular mechanisms are yet not fully understood.
Angelika Bondzio, Robert Pieper, Christoph Gabler, Christoph Weise, Petra Schulze, Juergen Zentek, Ralf Einspanier   +6 more
doaj   +1 more source

Alternative sulfur acquisition pathways in Neisseria gonorrhoeae [PDF]

, 2021
Neisseria gonorrhoeae is an obligate human pathogen responsible for the sexually transmitted infection, gonorrhoea. Its success as a pathogen is partly due to robust defence mechanisms that provide protection against oxidative stress encountered during ...
van Niekerk, Stacy Lyn
core  

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase [PDF]

, 2020
Rationale: Hydrogen sulfide (H2S) is a physiological mediator that regulates cardiovascular homeostasis. Three major enzymes contribute to the generation of endogenously produced H2S, namely cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) and
Aimilia Varela, Ingrid Fleming, Giuseppe Cirino, Valentina Vellecco, Antonia Katsouda, Athanasia Chatzianastasiou, Andreas Papapetropoulos, Zhen Li, Maria Peleli, Mariarosaria Bucci, Noriyuki Nagahara, David J Lefer, Constantinos H Davos, Sofia-Iris Bibli, Sven Zukunft   +14 more
core   +2 more sources