Results 11 to 20 of about 1,823 (144)

Unraveling the role of 3-mercaptopyruvate sulfurtransferase-derived hydrogen sulfide in triple-negative breast cancer chemoresistance [PDF]

Frontiers in Pharmacology
BackgroundTriple-negative breast cancer (TNBC) frequently develops resistance to chemotherapy. Cancer-supporting roles of the endogenous gaseous mediator hydrogen sulfide (H2S) have been identified.
Sousanna Hakim, Danira A. Habashy, Kelly Ascenção, Rana A. Youness, Rana A. Youness, Carole Bourquin, Carole Bourquin, Csaba Szabo, Mohamed Z. Gad, Reham M. Abdelkader   +9 more
doaj   +2 more sources

Acidity of persulfides and its modulation by the protein environments in sulfide quinone oxidoreductase and thiosulfate sulfurtransferase. [PDF]

J Biol Chem
Persulfides (RSSH/RSS-) participate in sulfur metabolism and are proposed to transduce hydrogen sulfide (H2S) signaling. Their biochemical properties are poorly understood. Herein, we studied the acidity and nucleophilicity of several low molecular weight persulfides using the alkylating agent, monobromobimane.
Benchoam D, Cuevasanta E, Roman JV, Banerjee R, Alvarez B.   +4 more
europepmc   +3 more sources

Structural and functional characterization of sulfurtransferase from Frondihabitans sp. PAMC28461. [PDF]

PLoS ONE
Sulfurtransferases transfer of sulfur atoms from thiols to acceptors like cyanide. They are categorized as thiosulfate sulfurtransferases (TSTs) and 3-mercaptopyruvate sulfurtransferases (MSTs). TSTs transfer sulfur from thiosulfate to cyanide, producing
Hackwon Do, Dieu Linh Nguyen, Yong-Yoon Ahn, Yewon Nam, YoonJi Kang, HoeJung Oh, Jisub Hwang, Se Jong Han, Kitae Kim, Jun Hyuck Lee   +9 more
doaj   +2 more sources

Functional potential of archaeal KEGG enzymes in the Moringa oleifera rhizosphere revealed by metagenomic analysis [PDF]

BMC Genomics
Background Archaea are a major domain of life that inhabit diverse and often extreme environments, contributing to biogeochemical cycles and participating in nutrient cycling within plant rhizospheric soils.
Lina Baz
doaj   +2 more sources

Systemic intracellular analysis for balancing complex biosynthesis in a transcriptionally deregulated Escherichia coli l‐Methionine producer

Microbial Biotechnology
l‐Methionine (l‐Met) has gained remarkable interest due to its multifaceted and versatile applications in the fields of nutrition, pharmaceuticals and clinical practice.
Claudia Harting, Attila Teleki, Marius Braakmann, Frank Jankowitsch, Ralf Takors   +4 more
doaj   +2 more sources

Solution structure of a single-domain thiosulfate sulfurtransferase from Arabidopsis thaliana. [PDF]

Protein Sci, 2006
AbstractWe describe the three‐dimensional structure of the product of Arabidopsis thaliana gene At5g66040.1 as determined by NMR spectroscopy. This protein is categorized as single‐domain sulfurtransferase and is annotated as a senescence‐associated protein (sen1‐like protein) and ketoconazole resistance protein (http://arabidopsis.org/info/genefamily ...
Cornilescu G, Vinarov DA, Tyler EM, Markley JL, Cornilescu CC.   +4 more
europepmc   +4 more sources

Redox Network Failure in Chronic Kidney Disease: Hydrogen Sulfide Deficiency, Reactive Sulfur Species Dysregulation and the Uremic Toxin–AhR–Mitochondrial Axis [PDF]

Antioxidants
Chronic kidney disease (CKD) affects approximately 700 million people worldwide and is a major contributor to end-stage renal disease (ESRD), cardiovascular morbidity, and premature mortality. Although oxidative stress has long been considered central to
Kuo-Cheng Lu, Chia-Chao Wu, Te-Chao Fang, Yi-Chou Hou, Cai-Mei Zheng, Chien-Lin Lu   +5 more
doaj   +2 more sources

The Role of Thiosulfate Sulfurtransferase in Oxidative Stress for Type 2 Diabetes Mellitus

Сахарный диабет
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with oxidative stress, leading to insulin resistance. Thiosulfate sulfurtransferase (TST) is mitochondrial enzyme involved in the reaction with cyanide, endogenous hydrogen sulfide (H₂S), and ...
M. M. Mawajdeh, T. A. Allwsh
doaj   +2 more sources

Transcriptomics of the Anthopleura Sea Anemone Reveals Unique Adaptive Strategies to Shallow‐Water Hydrothermal Vent

Ecology and Evolution
The nonsymbiotic sea anemone Anthopleura nigrescens dominates the shallow‐water hydrothermal vents off the coast of Kueishan Island, Taiwan. These vents represent some of the world's most extreme environments, with recorded pH values as low as 1.52 and ...
Mei‐Fang Lin, Li‐Lian Liu, Chen‐Tung Arthur Chen   +2 more
doaj   +2 more sources

Histone Deacetylase 9 Gene Deletion Ameliorates Aging-Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice. [PDF]

Aging Cell
Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Goo B, Ahmadieh S, Veerapaneni P, Shi H, Kim DS, Ogbi M, Chouhaita R, Cyriac N, Cave S, Liu L, Zhang Y, Du Q, Kim HW, Lei Y, Lu XY, Weintraub NL.   +15 more
europepmc   +2 more sources