Results 41 to 50 of about 9,662 (145)

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

EMBO Molecular Medicine, 2016
Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in the cellular metabolism. One of them is to function as an electron carrier in the reaction catalyzed by sulfide:quinone oxidoreductase (
Marta Luna‐Sánchez, Agustín Hidalgo‐Gutiérrez, Tatjana M Hildebrandt, Julio Chaves‐Serrano, Eliana Barriocanal‐Casado, Ángela Santos‐Fandila, Miguel Romero, Ramy KA Sayed, Juan Duarte, Holger Prokisch, Markus Schuelke, Felix Distelmaier, Germaine Escames, Darío Acuña‐Castroviejo, Luis C López   +14 more
doaj   +1 more source

H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression

Frontiers in Pharmacology, 2020
ObjectiveExcess of fructose consumption is related to life-treating conditions that affected more than a third of the global population. Therefore, to identify a newer therapeutic strategy for the impact prevention of high fructose injury in age-related ...
Yaroslav Pavlovskiy, Antonina Yashchenko, Oksana Zayachkivska   +2 more
doaj   +1 more source

HYDROGEN SULFIDE-RELEASING ANTI-INFLAMMATORY DRUG ATB-340 TREATMENT POTENTIALLY REDUCES MESENTERIC METAFLAMMATION IN THE EXPERIMENTAL AGE- AND HIGH FRUCTOSE DIETARY-INDUCED INJURY

Proceedings of the Shevchenko Scientific Society: Medical Sciences, 2021
Metaflammation (MF) is associated with visceral adiposities involved in the metabolic, cardiovascular, and gastrointestinal disease pathogenesis while their target therapeutic strategy is still limited.
Oleg Revenko, Vasyl Kovalyshyn, Antonina Yashchenko, John Wallace, Oksana Zayachkivska   +4 more
doaj   +1 more source

The Therapeutic Potential of H2S‐Releasing Platforms in Cardiovascular Applications

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
The Therapeutic Potential of H2S‐Releasing Platforms. ABSTRACT Once known as a toxic gas, hydrogen sulfide (H2S) is now making its way into many therapeutic applications. Similar to its other fellow endogenous gasotransmitters, nitric oxide and carbon monoxide, H2S is a small gas with a short half‐life, making it extremely capable of penetrating ...
Tia N. Shorter, Elizabeth J. Brisbois
wiley   +1 more source

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +1 more source

The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency

Frontiers in Physiology, 2017
Coenzyme Q (CoQ) is a lipid present in all cell membranes. One of the multiple metabolic functions of CoQ is to transport electrons in the reaction catalyzed by sulfide:quinone oxidoreductase (SQOR), the first enzyme of the oxidation pathway of sulfides (
Catarina M. Quinzii, Marta Luna-Sanchez, Marta Luna-Sanchez, Marcello Ziosi, Agustin Hidalgo-Gutierrez, Giulio Kleiner, Luis C. Lopez   +6 more
doaj   +1 more source

Cytoplasmic sulfurtransferases in the purple sulfur bacterium Allochromatium vinosum: evidence for sulfur transfer from DsrEFH to DsrC. [PDF]

PLoS ONE, 2012
While the importance of sulfur transfer reactions is well established for a number of biosynthetic pathways, evidence has only started to emerge that sulfurtransferases may also be major players in sulfur-based microbial energy metabolism.
Yvonne Stockdreher, Sofia S Venceslau, Michaele Josten, Hans-Georg Sahl, Inês A C Pereira, Christiane Dahl   +5 more
doaj   +1 more source

Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged Rats

Frontiers in Pharmacology, 2021
A high fructose diet (HFD) and advanced age are key factors for the gradual loss of physiological integrity of adipose tissue. Endogenous hydrogen sulfide (H2S) has beneficial effects on cytoprotection and redox balance.
Oleh Revenko, Yaroslav Pavlovskiy, Maryana Savytska, Antonina Yashchenko, Vasyl Kovalyshyn, Ilona Chelpanova, Olena Varyvoda, Oksana Zayachkivska   +7 more
doaj   +1 more source

Co-Cultures of Pseudomonas aeruginosa and Roseobacter denitrificans Reveal Shifts in Gene Expression Levels Compared to Solo Cultures

The Scientific World Journal, 2012
Consistent biosynthesis of desired secondary metabolites (SMs) from pure microbial cultures is often unreliable. In a proof-of-principle study to induce SM gene expression and production, we describe mixed “co-culturing” conditions and monitoring of ...
Crystal A. Conway, Nwadiuto Esiobu, Jose V. Lopez   +2 more
doaj   +1 more source

Hydrogen Sulfide and Polysulfides as Biological Mediators

Molecules, 2014
Hydrogen sulfide (H2S) is recognized as a biological mediator with various roles such as neuromodulation, regulation of the vascular tone, cytoprotection, anti-inflammation, oxygen sensing, angiogenesis, and generation of mitochondrial energy.
Hideo Kimura
doaj   +1 more source