Results 61 to 70 of about 1,823 (144)
VIEW, Volume 6, Issue 3, June 2025.Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) poses a significant public health risk, yet effective treatments are limited due to the lack of suitable models. This study developed a more realistic model of SI‐ALI using organ‐on‐a‐chip and organoid technologies, identified key molecules such as catechol‐O‐methyltransferase and ...
Junmin Li +12 more
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Studies of functionally important structural flexibility of thiosulfate sulfurtransferase
Biophysical Journal, 1980 The enzyme thiosulfate sulfurtransferase (TST; rhodanese; EC 2.8.1.1) catalyzes the transfer of the outer sulfur of thiosulfate (S/sub 2/O/sub 3//sup - -/) to a variety of nucleophilic acceptors such as cyanide (CN/sup -/). During the course of this reaction the enzyme cycles through two stable isolatable catalytic intermediates: the free enzyme, (E ...
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Poultry Science, 1997 This study was undertaken to investigate the relationships between stage of embryonic development and early posthatch growth and the level of rhodanese (thiosulfate:cyanide sulfurtransferase) activity in different regions of the digestive tract and liver of chickens. The embryos were studied at 14, 17, and 20 d and chickens were 1, 2, and 3 wk old. All
M, Aminlari +3 more
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Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells [PDF]
Scientific Reports, 2019 AbstractCyanide is a toxic compound that is converted to the non-toxic thiocyanate by a rhodanese enzyme. Rhodaneses belong to the family of transferases (sulfurtransferases), which are largely studied. The sulfur donor defines the subfamily of these enzymes as thiosulfate:cyanide sulfurtransferases or rhodaneses (TSTs) or 3-mercaptopyruvate ...
Meza, A. N. +4 more
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Role of hydrogen sulfide in health and disease
MedComm, Volume 5, Issue 9, September 2024.Abstract In the past, hydrogen sulfide (H2S) was recognized as a toxic and dangerous gas; in recent years, with increased research, we have discovered that H2S can act as an endogenous regulatory transmitter. In mammals, H2S‐catalyzing enzymes, such as cystathionine‐β‐synthase, cystathionine‐γ‐lyase, and 3‐mercaptopyruvate sulfurtransferase, are ...
Yu‐Qing Jin +9 more
wiley +1 more source
Acta Physiologica, Volume 240, Issue 3, March 2024.Abstract Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected and connected the available biochemical pathways and integrated them into a functional metabolic map.
Panagiotis N. Chatzinikolaou +7 more
wiley +1 more source
Chinese Medicine, 2012 Background The hepatoprotective potential of Phellinus linteus polysaccharide (PLP) extracts has been described. However, the molecular mechanism of PLP for the inhibition of liver fibrosis is unclear. This study aims to investigate the molecular protein
Wang Hualin +6 more
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Bacterial Isothiocyanate Biosynthesis by Rhodanese‐Catalyzed Sulfur Transfer onto Isonitriles
ChemBioChem, Volume 25, Issue 3, February 1, 2024.A novel biosynthetic pathway towards isothiocyanate natural products is identified. In vivo and in vitro biotransformation show that rhodanese‐like proteins (Rhd), known for the detoxification of cyanide, have been recruited and neofunctionalized to catalyze sulfur incorporation into isonitriles in bacteria.
Mandy D. Mlotek +2 more
wiley +1 more source
Discovery of a small molecule allosteric activator of human thiosulfate sulfurtransferase
, 2023 Recent studies showed that thiosulfate sulfurtransferase (TST) is one of the few peripherally expressed genes that has been identified as a genetic risk factor for metabolic health, with clear evidence of a negative correlation with the development of obesity-related type 2 diabetes with insulin resistance2,3.
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Microbiology SpectrumMembers of the genus Halanaerobium are widely distributed in hypersaline environments, including oil and gas reservoirs, and saline lake sediment. However, a comprehensive understanding of their physiological traits, metabolic capacities, adaptive ...
Yu He +22 more
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