Results 51 to 60 of about 1,823 (144)

Dimethyl Sulfoxide (DMSO) as a Potential Source of Interference in Research Related to Sulfur Metabolism—A Preliminary Study

Antioxidants
Dimethyl sulfoxide (DMSO), an organosulfur compound, is widely used as the gold standard solvent in biological research. It is used in cell culture experiments and as a component of formulations in in vivo studies.
Marta Kaczor-Kamińska, Kinga Kaszuba, Anna Bilska-Wilkosz, Małgorzata Iciek, Maria Wróbel, Kamil Kamiński   +5 more
doaj   +1 more source

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026.
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Sorghum Poisoning in Livestock: Mechanisms, Risks, and Sustainable Mitigation Strategies

International Journal of Agronomy, Volume 2026, Issue 1, 2026.
Sorghum (Sorghum bicolor L. Moench) is a drought‐tolerant crop grown in both arid and semiarid regions and serves as both food and fodder. Under environmental stresses, sorghum accumulates cyanogenic glucosides, especially dhurrin. Through ingestion, dhurrin is hydrolyzed into a toxic element called hydrogen cyanide (HCN).
Mahmud Sindid Ikram, Sumiya Akter Moni, Othmane Merah   +2 more
wiley   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Cysteine Signalling in Plant Pathogen Response

Plant, Cell &Environment, Volume 48, Issue 10, Page 7107-7122, October 2025.
ABSTRACT The amino acid cysteine is the precursor for a wide range of sulfur‐containing functional molecules in plants, including enzyme cofactors and defence compounds. Due to its redox active thiol group cysteine is highly reactive. Synthesis and degradation pathways are present in several subcellular compartments to adjust the intracellular cysteine
Jannis Moormann, Björn Heinemann, Cecile Angermann, Anna Koprivova, Ute Armbruster, Stanislav Kopriva, Tatjana M. Hildebrandt   +6 more
wiley   +1 more source

Mechanisms on boron-induced alleviation of aluminum-toxicity in Citrus grandis seedlings at a transcriptional level revealed by cDNA-AFLP analysis.

PLoS ONE, 2015
The physiological and biochemical mechanisms on boron (B)-induced alleviation of aluminum (B)-toxicity in plants have been examined in some details, but our understanding of the molecular mechanisms underlying these processes is very limited.
Xin-Xing Zhou, Lin-Tong Yang, Yi-Ping Qi, Peng Guo, Li-Song Chen   +4 more
doaj   +1 more source

MTA‐TST Axis‐Mediated Apoptosis Activation: A Multi‐Omics Insight Into High‐Protein Diet's Anti‐Adiposity Effect

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
High protein diet reduced visceral adipose tissue through MTA‐TST‐Bak/Casp‐3 axis, suggesting that MTA has the potential to be developed as a functional substance for obesity prevention and control. ABSTRACT To explore the mechanism of a high‐protein diet (named high protein and rich fat diet, HPRFD) with weight loss effect regulating visceral fat ...
Xinli Yang, Yueyue Wang, Zhe Shi, Aiting Wang, Jianglan Long, Dan Yan   +5 more
wiley   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Cyclic AMP Receptor Protein Acts as a Transcription Regulator in Response to Stresses in Deinococcus radiodurans.

PLoS ONE, 2016
The cyclic AMP receptor protein family of transcription factors regulates various metabolic pathways in bacteria, and also play roles in response to environmental changes.
Su Yang, Hong Xu, Jiali Wang, Chengzhi Liu, Huizhi Lu, Mengjia Liu, Ye Zhao, Bing Tian, Liangyan Wang, Yuejin Hua   +9 more
doaj   +1 more source