Oxidative Stress and Iron Addiction: A Comparative Study of 1321N1 Astrocytoma and T98G Glioblastoma Cells with Differential Expression of L-Cysteine-Metabolizing Enzymes [PDF]
BiomoleculesGliomas are central nervous system primary tumors that are distinguished by heterogeneity, broad-based infiltration, and metabolic reprogramming that sustains proliferation, invasion, and therapy refractoriness.
Halina Jurkowska +5 more
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Thiosulphate sulfurtransferase: Biological roles and therapeutic potential [PDF]
Redox BiologyMitochondria are central to eukaryotic cell function, driving energy production, intermediary metabolism, and cellular homeostasis. Dysregulation of mitochondrial function often results in oxidative stress, a hallmark of numerous diseases, underscoring ...
Yang Luo +6 more
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Cyanide overproduction impairs cellular bioenergetics in Down syndrome [PDF]
NeurotherapeuticsCyanide exerts its toxic effects primarily by inhibiting mitochondrial Complex IV (Cytochrome c oxidase, CCOx). Recent studies have shown that mammalian cells can endogenously produce cyanide from glycine via a lysosomal pathway.
Maria Petrosino +7 more
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Structural and functional characterization of sulfurtransferase from Frondihabitans sp. PAMC28461. [PDF]
PLoS ONESulfurtransferases transfer of sulfur atoms from thiols to acceptors like cyanide. They are categorized as thiosulfate sulfurtransferases (TSTs) and 3-mercaptopyruvate sulfurtransferases (MSTs). TSTs transfer sulfur from thiosulfate to cyanide, producing
Hackwon Do +9 more
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Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes [PDF]
BiomoleculesLeukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta +4 more
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Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications [PDF]
International Journal of Molecular Sciences, 2022 Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms ...
Silvia Buonvino +2 more
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Deficiency of thiosulfate sulfurtransferase mediates the dysfunction of renal tubular mitochondrial fatty acid oxidation in diabetic kidney disease. [PDF]
Cell Death DifferZhang JX +7 more
europepmc +3 more sources
Structural analysis of Thiosulfate: cyanide sulfurtransferase (Rhodanese)
, 2018 Mozhdeh Shahmoradi, Adrian Salavaty
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Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020 Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the ...
Paul D. Kruithof +8 more
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Discovery of a small molecule allosteric activator of human thiosulfate sulfurtransferase
, 2023 Recent studies showed that thiosulfate sulfurtransferase (TST) is one of the few peripherally expressed genes that has been identified as a genetic risk factor for metabolic health, with clear evidence of a negative correlation with the development of obesity-related type 2 diabetes with insulin resistance2,3.
Zayana Al Dahmani-Al Zakwani
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