Results 181 to 190 of about 5,865 (290)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray   +16 more
wiley   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux   +7 more
wiley   +1 more source

Dynamic memory in rodent C‐fibres and its impact on spinal nociceptive processing

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Nociceptive C‐fibres display activity‐dependent slowing (ADS) whereby successive action potentials are conducted progressively slower thus regulating the temporal relay of pain signals. This study shows that the ADS induced by short stimulus trains (which mimic stimulus evoked firing, shown in orange) is modified by prior ...
Atanaska N. Velichkova, Carole Torsney
wiley   +1 more source

One-Pot Gateway to Quinazoline-Thiohydantoin Fused Scaffolds and Discovery of Their Antileukemic Activity. [PDF]

open access: yesJACS Au
Kersting L   +13 more
europepmc   +1 more source

In Transected Nerves, Distal Repair Schwann Cells at the Injury Site Direct and Accelerate Axonal Regrowth

open access: yesGlia, Volume 74, Issue 10, October 2026.
After nerve transection in larval zebrafish, proximal and distal Schwann cells have distinct functions at the injury site. Distal repair Schwann cells promote axonal regrowth. Axonal regrowth is normal in mutants with only a few macrophages. ABSTRACT In vertebrate peripheral nerves, damaged axons can regrow after injury, but the outcomes of ...
Daniel E. Lysko   +2 more
wiley   +1 more source

Tailored Catalysts Based on Polymers of Intrinsic Microporosity for Asymmetric Aza-Henry Reaction of Pyrazolinone Ketimines in Batch and Flow. [PDF]

open access: yesACS Appl Polym Mater
Sánchez-Molpeceres R   +6 more
europepmc   +1 more source

Formulation‐Dependent Cytotoxic Effects of Commercial and Analytical‐Grade Mancozeb in C6 Glial Cells

open access: yesJournal of Applied Toxicology, Volume 46, Issue 10, Page 3542-3549, October 2026.
ABSTRACT Mancozeb (MZ) is a widely used dithiocarbamate fungicide composed of manganese (Mn) and zinc (Zn) complexes. Increasing concern has been raised regarding its occupational and human health relevance, particularly due to its neurotoxic potential associated with Mn‐related cellular dysfunction.
Lavínia Lazzarotti   +5 more
wiley   +1 more source

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