Results 191 to 200 of about 41,140 (322)

Tailored Catalysts Based on Polymers of Intrinsic Microporosity for Asymmetric Aza-Henry Reaction of Pyrazolinone Ketimines in Batch and Flow. [PDF]

ACS Appl Polym Mater
Sánchez-Molpeceres R, Zhan P, Martín L, Maestro A, Miguel JA, Comesaña-Gándara B, Andrés JM.   +6 more
europepmc   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni, Maria Luisa Di Paolo, Antonio Laghezza, Giorgio Cozza, Francesco Piazzola, Laura Facci, Emma Marcolin, Elena Roggiolani, Luca Piemontese, Anna Minarini, Morena Zusso, Lisa Dalla Via, Michela Rosini   +12 more
wiley   +1 more source

One-Pot Gateway to Quinazoline-Thiohydantoin Fused Scaffolds and Discovery of Their Antileukemic Activity. [PDF]

JACS Au
Kersting L, Zippel C, Herrmann L, Elbadawi M, Seo EJ, Heckmann F, Saeed MEM, Gaube A, Tailor D, Dheeraj A, Malhotra SV, Muehlich S, Efferth T, Tsogoeva SB.   +13 more
europepmc   +1 more source

Barbituric Acids as Nucleophiles in Enantioselective Mannich Reactions: Organocatalytic Access to Quaternary Aminopyrazolone–Barbiturate Adducts

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
An enantioselective Mannich reaction using barbituric acids as nucleophiles provides access to chiral heterocycles bearing quaternary stereocenters. The transformation is catalyzed by a bifunctional thiourea with high selectivity. An immobilized catalyst enables recycling and application under continuous‐flow conditions, offering an efficient and ...
Rodrigo Sánchez‐Molpeceres, Mónica Llorente‐Pérez, Laura Martín, Alicia Maestro, José M. Andrés   +4 more
wiley   +1 more source

Fast One‐Step Microwave Synthesis of 2H–1T MoS2 for Efficient Hydrogen Evolution

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
MoS2 nanoflakes were rapidly synthesized in a microwave hydrothermal reactor for HER catalysis in a single 15‐min step. For the first time, in situ monitoring of synthesis parameters was performed using a camera, while XPS and XRD analyses confirm that the process forms MoS2 nanoflowers with mixed 2H–1T seeds, directing the subsequent growth of pure 1T
Elisabetta Campedelli, Marco Mazzucato, Mattia Parnigotto, Marzio Rancan, Christian Durante   +4 more
wiley   +1 more source

Dehydroabietyl squaramide incorporating chiral pyrrolidine for highly diastereo- and enantioselective Michael reaction between cyclohexanone and β-nitrostyrenes. [PDF]

RSC Adv
Zhang ZW, Xiong K, Liu SW, Deng YQ.
europepmc   +1 more source

An Improved One‐Pot Synthesis for Tetramethylthiuram Monosulfide and Triphenylthiophosphate in Batch and Continuous Flow

Chemistry–Methods, Volume 6, Issue 8, August 2026.
The one‐pot reaction simultaneously producing two high‐value fine chemicals can now be carried out in both batch and flow modes, with elevated isolated yields of above 90% compared to previous methods. By using a more operational solvent, the selectivity, reaction rate, and separation efficiency have all been significantly improved.
Xing‐Jian Li, Xiao Wang
wiley   +1 more source

Isothiourea catalysed enantioselective generation of point and axially chiral iminothia- and iminoselenazinanones. [PDF]

Chem Sci
Nimmo AJ, Goodfellow AS, Guntley JT, McKay AP, Cordes DB, Bühl M, Smith AD.   +6 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Synthesis and Structure-Activity Relationship of Thiourea Derivatives Against Leishmania amazonensis. [PDF]

Pharmaceuticals (Basel)
Viana GM, Cunha-Junior EFD, Assumpção PWMC, Rezende MG, Emiliano YSDS, Soares LMDS, Pereira GRC, Rodrigues CR, Cabral LM, Torres-Santos EC.   +9 more
europepmc   +1 more source