Results 191 to 200 of about 5,865 (290)

Synthesis and Structure-Activity Relationship of Thiourea Derivatives Against Leishmania amazonensis. [PDF]

Pharmaceuticals (Basel)
Viana GM, Cunha-Junior EFD, Assumpção PWMC, Rezende MG, Emiliano YSDS, Soares LMDS, Pereira GRC, Rodrigues CR, Cabral LM, Torres-Santos EC.   +9 more
europepmc   +1 more source

Thiourea and Wound Repair [PDF]

BMJ, 1942
openaire   +2 more sources

Exploring Interactive Effects of Arsenic and Selenium Exposure on Larval Zebrafish (Danio rerio)

Environmental Toxicology, Volume 41, Issue 10, Page 1027-1040, October 2026.
ABSTRACT Arsenic contamination in aquatic ecosystems is a major environmental concern. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids commonly co‐occur in the environment, there is a pressing need for further research ...
Owen Luo, Jinnath Rehana Ritu, Md Helal Uddin, Sravan Kumar Putnala, Mahesh Rachamalla, Som Niyogi, Douglas P. Chivers   +6 more
wiley   +1 more source

Glutathione‐Responsive Acyl‐Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
The self‐immolation of disulfide‐based mRNA modifications in response to endogenous glutathione (GSH) promotes a gradual release of translatable mRNA within the cell, leading to improved nuclease resistance, tunable release properties, and a significant increase (up to 600%) of target protein production over time. This strategy offers an exciting proof
Mary E. Flood, Sathishkumar Kurusamy, Mark Berney, C. Mark Smales, Elizabeth M. Topp, Joanna F. McGouran, Steven Ferguson   +6 more
wiley   +2 more sources

Dehydroabietyl squaramide incorporating chiral pyrrolidine for highly diastereo- and enantioselective Michael reaction between cyclohexanone and β-nitrostyrenes. [PDF]

RSC Adv
Zhang ZW, Xiong K, Liu SW, Deng YQ.
europepmc   +1 more source

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Aged mice exhibited impaired motor behavior and neuromuscular hypoexcitability, yet cortical output to muscle was enhanced, and motor cortex layer V pyramidal neurons were hyperexcitable, with altered synaptic inputs and excitability‐related transcriptional changes.
Jose A. Viteri, Nathan R. Kerr, Fereshteh B. Darvishi, Anna Roshani Dashtmian, Charles D. Brennan, Sindhuja N. Ayyagari, Peter J. Moore, Meifang Wang, Harper Snyder, Baocong Yu, Joseph M. Santin, W. David Arnold   +11 more
wiley   +1 more source

Isothiourea catalysed enantioselective generation of point and axially chiral iminothia- and iminoselenazinanones. [PDF]

Chem Sci
Nimmo AJ, Goodfellow AS, Guntley JT, McKay AP, Cordes DB, Bühl M, Smith AD.   +6 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Pyrazolyl thioureas were designed and synthesized as sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) inhibitors. 6a (IC50 (SIRT1) = 5.3 µM; IC50 (SIRT2) = 2.2 µM) and 7f (IC50 (SIRT1) = 12.4 µM; IC50 (SIRT2) = 13.6 µM) showed micromolar inhibition on target enzymes and HepG2‐based assays confirmed a SIRT2‐mediated effect on tubulin acetylation. Docking studies
Matteo Lusardi, Cecilia Astigiano, Deianira Bellitto, Matteo Raineri, Giorgia Guccione, Annalisa Salis, Elena Cichero, Chiara Brullo, Marco Ponassi, Santina Bruzzone, Andrea Spallarossa   +10 more
wiley   +1 more source

Cell surface localization of receptors considered nonfunctional and orphan bitter taste receptors. [PDF]

Curr Res Food Sci
Kumar P, Behrens M.
europepmc   +1 more source

π‐Extended Silyl Enolates as Emerging Platforms in Radical Chemistry

European Journal of Organic Chemistry, Volume 29, Issue 36, 24 September 2026.
This review covers the emerging role of π‐extended silyl polyenol ethers in radical chemistry. It highlights their versatile roles as electron‐rich SOMOphiles, silyl radical cation precursors, and nucleophilic partners in radical–polar crossover manifolds, while considering recent advances in photoredox catalysis, electrochemistry, and transition metal‐
Debora Guazzetti, Kelly Bugatti, Claudio Curti, Franca Zanardi   +3 more
wiley   +1 more source