Results 91 to 100 of about 828,765 (377)
Frontiers in Oncology, 2023 Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture (2DCC) and animal models and is widely used in oncology research.
Long Zhang +11 more
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Three-Dimensional Cell Cultures in Drug Discovery and Development [PDF]
SLAS DISCOVERY: Advancing Life Sciences R&D, 2017 The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease.
Fang, Ye, Eglen, Richard M.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Reprogramming of the Genome-Wide DNA Methylation Landscape in Three-Dimensional Cancer Cell Cultures [PDF]
, 2023 Alma Jaqueline Heredia-Mendez +2 more
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Three‐dimensional cell culture model utilization in cancer stem cell research
Biological Reviews of The Cambridge Philosophical Society, 2017 Three‐dimensional (3D) cell culture models are becoming increasingly popular in contemporary cancer research and drug resistance studies. Recently, scientists have begun incorporating cancer stem cells (CSCs) into 3D models and modifying culture ...
Z. Bielecka +4 more
semanticscholar +1 more source
An in vitro study showing the three-dimensional microenvironment influence over the behavior of head and neck squamous cell carcinoma [PDF]
, 2011 Objectives: The Head and Neck Squamous Cell Carcinoma (HNSCC) ranks sixth worldwide. The mechanisms of growth, invasion and metastasis of this pathology are extensively studied and generally related to specific variations in signaling pathways like the ...
Corrêa-Abrahão, Aline +4 more
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Thyroid Research, 2021 Background Three-dimensional (3D) cell culture methods are identified for simulating the biological microenvironment and demonstrating more similarity to in vivo circumstances. Anaplastic thyroid carcinoma (ATC) is a lethal endocrine malignancy.
Hilda Samimi +6 more
doaj +1 more source
Role of geometrical cues in bone marrow-derived mesenchymal stem cell survival, growth and osteogenic differentiation [PDF]
, 2018 Mesenchymal stem cells play a vital role in bone formation process by differentiating into osteoblasts, in a tissue that offers not a flat but a discontinuous three-dimensional (3D) topography in vivo. In order to understand how geometry may be affecting
Bidan CM +10 more
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Imaging and Analysis of Three-Dimensional Cell Culture Models [PDF]
, 2009 Three-dimensional (3D) cell cultures are important tools in cell biology research and tissue engineering because they more closely resemble the architectural microenvironment of natural tissue, compared to standard two-dimensional cultures. Microscopy techniques that function well for thin, optically transparent cultures, however, are poorly suited for
Benedikt W, Graf, Stephen A, Boppart
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