Results 21 to 30 of about 828,765 (377)

Three-dimensional cell cultures as a new tool in drug discovery [PDF]

, 2016
Background and purpose: Producing of reliable information about pharmacological activity of new chemical entities is essential in early stages of drug discovery and development. There is a continuous need for improvement of existing in vitro technologies,
Karmen Brajša
openalex   +3 more sources

Quantitative volumetric Raman imaging of three dimensional cell cultures [PDF]

Nature Communications, 2017
The ability to simultaneously image multiple biomolecules in biologically relevant three-dimensional (3D) cell culture environments would contribute greatly to the understanding of complex cellular mechanisms and cell-material interactions.
Bergholt, MS, Kallepitis, C, Leonardo, V, Maynard, SA, Mazo, MM, Skaalure, SC, Stevens, MM   +6 more
core   +10 more sources

Preconditioned Cell Array Optimized for a Three-Dimensional Culture of Hepatocytes [PDF]

Cell Transplantation, 2009
Three-dimensional culture procedures have attracted attention in various fields of cell biology. A newly developed cell array assisted in the formation of hepatocyte spheroids by two innovations: 1) micropatterning by a hydrophilic polymer, and 2) the ...
Yoshitaka Miyamoto, Takeshi Ikeya, Shin Enosawa   +2 more
doaj   +2 more sources

Three-dimensional cell culture of human mesenchymal stem cells in nanofibrillar cellulose hydrogels [PDF]

MRS Communications, 2017
Human mesenchymal stem cells (MSCs) are the most intensely studied and clinically used adult stem cell type. Conventional long-term cultivation of MSCs as a monolayer is known to result in a reduction of their functionality and viability.
Ioannis Azoidis, J. Metcalfe, James Reynolds, S. Keeton, S. Hakki, J. Sheard, D. Widera   +6 more
semanticscholar   +3 more sources

Microfluidic three-dimensional cell culture of stem cells for high-throughput analysis. [PDF]

World J Stem Cells, 2019
Although the recent advances in stem cell engineering have gained a great deal of attention due to their high potential in clinical research, the applicability of stem cells for preclinical screening in the drug discovery process is still challenging due
Kim JA, Hong S, Rhee WJ.
europepmc   +2 more sources

Three-Dimensional Cell Culture Models to Study Respiratory Virus Infections Including COVID-19. [PDF]

Biomimetics (Basel), 2021
Harb A, Fakhreddine M, Zaraket H, Saleh FA.   +3 more
europepmc   +3 more sources

Bone Graft Paste Nanohydroxyapatite Chitosan-Gelatin (nHA/KG) for Periodontal Regeneration: Study on Three-Dimensional Cell Culture. [PDF]

Eur J Dent
Harsas NA, Bachtiar EW, Amir LR, Mauludin R, Sunarso S, Yosefa V, Savvyana M, Tadjoedin FM, Soeroso Y.   +8 more
europepmc   +3 more sources

8468 Development And Characterisation Of Three-Dimensional Cell Culture Models Of Adrenocortical Carcinoma [PDF]

J Endocr Soc
Sarah Feely, Nathan Mullen, Padraig Donlon, Constanze Hantel, Michael Conall Dennedy   +4 more
europepmc   +2 more sources

Three-dimensional cell culture: from evolution to revolution [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2018
Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the development of high-fidelity modelling of several tissuesin vitro.
Sharmin Alhaque, M. Themis, H. Rashidi
semanticscholar   +6 more sources

Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development

Micromachines, 2021
Three-dimensional multicellular spheroids (MCSs) have received extensive attention in the field of biomedicine due to their ability to simulate the structure and function of tissues in vivo more accurately than traditional in vitro two-dimensional models
Honglin Shen, Shuxiang Cai, Chuanxiang Wu, Wenguang Yang, Haibo Yu, Lianqing Liu   +5 more
doaj   +1 more source