Results 81 to 90 of about 452,379 (303)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Extreme value theory applied to the auroral electrojet indices
Earth and Planetary PhysicsThe study of extreme weather and space events has gained paramount importance in modern society owing to rapid advances in high technology. Understanding and describing exceptional occurrences plays a crucial role in making decisive assessments of their ...
Si Chen +4 more
doaj +1 more source
Threshold autoregression with a near unit root [PDF]
unit root;autoregressive ...
Hansen,B.E., Caner,M.
core
, 2019 Supplemental Material, Supplemental_1_References_for_145_TLVs_Alphabetical_Order for 142 ACGIH Threshold Limit Values® (TLV®s) established from 2008-2018 lack consistency and transparency by Carr J Smith, and Thomas A Perfetti in Toxicology Research and ...
Thomas A Perfetti (5195048) +1 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Carrier-to-Noise-Threshold Filtering on Off-Shore Wind Lidar Measurements
Sensors, 2019 Wind lidar observations are characterized by a Carrier-to-Noise-Ratio that is often used to filter the observations. The choice of the Carrier-to-Noise-Ratio threshold value for the wind lidar observations is found to have an effect on the climatological
Sven-Erik Gryning, Rogier Floors
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Graphical identification of TAR models [PDF]
This paper proposes an automatic procedure to identify Threshold Autoregressive models and specify the threshold values. The proposed procedure is based on recursive estimation of arranged autoregression. The main advantage of the proposed procedure over
Daniel Peña +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source