Results 91 to 100 of about 754,428 (266)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Attacks on Threshold Signature Schemes with Traceable Signers
, 2012 [[abstract]]In 1998, Wang et al. proposed two new (t,n)-threshold signature schemes with traceable signers that can withstand conspiracy attacks without attaching a secret number.
Tseng, Yuh-Min; Jan, J. K.
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
SNR-Based Antenna Selection with Threshold Value in Wireless Channels
, 2013 21st Signal Processing and Communications Applications Conference (SIU) -- APR 24-26, 2013 -- CYPRUSIn this study, in order to reduce the end-to-end bit error rate (BER) at the destination, two different antenna selection models based on signal to noise ...
Aydin, Erdogan +2 more
core +2 more sources
Advanced array processing techniques and systems
, 2009 Research and development on smart antennas, which are recognized as a promising technique to improve the performance of mobile communications, have been extensive in the recent years.
Li, M.
core
An improved infrared image processing method based on adaptive threshold denoising
, 2019 This paper combines the image adaptive threshold denoising algorithm and performs double threshold mapping processing to the infrared image, which effectively reduces the influence of these phenomena to the infrared image and improves the quality of the ...
Yu Binbin
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source